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Biomedical subjects

P Mennonna

Publications and source records attributed to P Mennonna.

At least 37 records · Page 2Linked to original sources
PubMed1982

A case of cystic meningioma mimicking an astrocytoma.

In a 25-year-old woman, suddenly complaining of irritation and soon after of paretic symptoms in the right upper limb, a CT scan showed a large cystic mass in the left parietal lobe. As cerebral angiography was not helpful, a cystic astrocytoma was suspected. After total surgical removal of the cyst, the histological examination revealed, to our surprise, a syncytial meningioma. The rate cases of similar cystic meningioma reported in the literature are reviewed and the usefulness of biopsy on every suspected cerebral neoplasm is stressed.

Adult↗
PubMedDate not supplied

The Doppler ophthalmic test: report of a study on its value in diagnosis of internal carotid artery insufficiency.

The Authors have investigated the significance and the limits of the directional Doppler method in a group of subjects affected by internal carotid obstruction in various sites and degree. On the basis of the obtained results the Authors point out how this method represents a concrete progress in the field of non invasive diagnosis of the insufficiency of this artery.

Arterial Occlusive Diseases↗
PubMedDate not supplied

Oligodendroglioma: CD44 as a possible prognostic opportunity.

CD44, in its standard form as well in its isoforms, is a cell surface adhesion glycoprotein which occurs in a wide variety of non-neoplastic and neoplastic cells. CD44 has been considered to be implicated in tumoral growth and in metastatic potential. We studied the immunohistochemical expression of CD44 standard in 30 oligodendrogliomas (19 primary lesions and 11 recurrences) in order to verify its possible prognostic role. Twelve primary oligodendrogliomas (63%) and 8 recurrences (73%) were CD44-positive. Three of 9 (33%) primary oligodendrogliomas with a Smith grade A-B and 9 of 10 (90%) primary oligodendrogliomas with a Smith grade C-D were found to be in CD44H-positive (p = 0.020). Three of 9 (33%) primary oligodendrogliomas that had not relapsed and 9 of 10 (90%) successively relapsed primary lesions were found to be CD44H-positive (p = 0.020). Median survival of the patients with a CD44H-positive lesion was 84 months; median survival of the patients with a CD44H-negative lesion was 91 months. We conclude that CD44H could have prognostic value regarding the occurrence of relapses.

Adult↗
PubMedDate not supplied

Inducible cyclooxygenase (COX-2) in glioblastoma--clinical and immunohistochemical (COX-2-VEGF) correlations.

Cyclooxygenase-2 (COX-2) is the inducible form of the enzyme responsible for the first step in the prostaglandin synthesis. COX-2 upregulation is demonstrated in different tumors. COX-2 products may modulate tumoral growth, apoptosis, metastasis, multidrug resistance and angiogenesis. Moreover, the antitumoral effect of the COX inhibitors has been documented. We studied the immunohistochemical expression and the prognostic value of COX-2 on 43 surgical specimens of glioblastoma-affected patients. Furthermore, we evaluated the correlation between the immunohistochemical expression of COX-2 and vascular endothelial growth factor (VEGF). Of the glioblastomas, 63% resulted as COX-2-positive. Median survival of the patients with COX-2-positive lesions was 10 months; median survival of the patients with COX-2 negative glioblastoma was 21 months (NS). All 4 patients who survived longer than 24 months had COX-2 negative lesions (p = 0.017). Concordance between COX-2 and VEGF was documented in 60% of the cases. Our findings show that glioblastoma can immunohistochemically express COX-2 and that its expression is unrelated with VEGF and significantly less frequent in the long survivors. Nevertheless, the absence of statistical correlation with survival time advises further studies on larger series to ascertain the concrete prognostic value of COX-2 in glioblastoma.

Aged↗
PubMedDate not supplied

Cytological features of a craniopharyngioma.

The fine needle aspiration cytology of a cystic suprasellar lesion, which caused bilateral hemianopia in a woman aged 63, resulted to be consistent with a craniopharyngioma and was confirmed by tissue diagnosis. The cytological pattern showed macrophages and debris with calcifications indicating the presence of a cyst. Furthermore squamous cells of basal type and ghost cells were identified. These findings together with the seat of the lesion allowed for the diagnosis of craniopharyngioma and for the differentiation from other cystic lesions of the same region. The case confirms the value of the fine needle aspiration cytology in the detection of craniopharyngioma and points out cytological peculiarities of this not rare neoplasm.

Biopsy, Needle↗
PubMedDate not supplied

[Intracranial aneurysm in children. Peculiar clinico-radiologic aspects and the choice of surgical timing].

The authors report their experience with 11 patients in pediatric age affected by intracranial aneurysms. They try to reply to the question: "Are aneurysms congenital?" and consider the different problems concerning clinical suspect of intracranial haemorrhage. Vasospasm is an important prognostic factor in adults but in children it doesn't affect surgical "timing" as it happens in older patients. Since the incidence of rebleeding in patients treated conservatively is very high, Authors conclude that a prompt surgery in necessary in these young patients.

Adolescent↗