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Biomedical subjects

P Meister

Publications and source records attributed to P Meister.

At least 37 records · Page 2Linked to original sources
PubMed1996

Malignant fibrous histiocytoma: histomorphological pattern or tumor type.

During the past years MFH has obviously been used as a diagnostic waste basket for hard to classify tumours of all kinds. Immunohistochemistry revealed insights into cellular differentiation of neoplastic proliferations, also raising new questions because of unexpected antigen expression, as, for instance, cytokeratins in MFH. Thus, a number of tumours originally diagnosed as MFH could be reclassified, i.e., as leiomyosarcoma, melanoma or anaplastic carcinoma. Nevertheless, there remain a certain number of sarcomas which lack any evidence of special cellular differentiation. These proliferations of primitive mesenchymal or fibroblastic cells, often with a typical histological, storiform pattern, qualify as MFH. Using these strict criteria, the diagnosis of MFH will become rarer, though not obsolete (like hemaugioperizytoma years ago!).

Histiocytoma, Benign Fibrous↗
PubMed1995

Adult Wilms' tumor. Report of two cases and review of the literature.

BACKGROUND: Wilms' tumor is rare in adults. The recommended treatments for patients with Stage II adult Wilms' tumor with favorable histology (FH) nephroblastomas are conflicting. METHODS: Two patients with Stage II, favorable histology, adult nephroblastomas are described. Current treatment modalities are discussed and the literature is reviewed. RESULTS: The first patient, a 52-year-old woman, probably had a late local relapse of a Wilms' tumor 21 years after nephrectomy because of a renal tumor originally diagnosed as reticular sarcoma. In this case, a recurring or an extrarenal Wilms' tumor should have been considered. After the tumor was removed, the patient received adjuvant chemotherapy with dactinomycin and vincristine and was disease free 44 months after diagnosis. The Wilms' tumor in the second patient, a 33-year-old woman, was discovered accidentally and classified as Stage II/FH based on preoperative biopsy. She was treated with radical nephrectomy and adjuvant chemotherapy with dactinomycin and vincristine. This patient was disease free 24 months after surgery. CONCLUSIONS: Surgery and two-drug chemotherapy with dactinomycin and vincristine is suggested for patients with Stage II adult Wilms' tumor with FH nephroblastomas.

Adult↗
PubMed1995

[Interstitial nephritis with acute renal failure in Ascaris lumbricoides infection].

A girl aged 14 years, 8 months presented with painful swelling of cervical lymph nodes. On frozen section malignancy could be ruled out. There were nonspecific inflammatory changes. In the presence of a prominent eosinophilic reaction the possibility of a drug reaction had been suggested. Because of decreasing renal function, dialysis was started 1 day after lymph node extirpation. A renal biopsy revealed acute interstitial nephritis-again with eosinophils. At this point parasitosis was discussed. There was a slightly elevated titer for filariasis. Shortly thereafter, also eggs of Ascaris lumbricoides were found in the feces. A pulmonary infiltrate made its appearance, with eosinophils in the pleural fluid. About 20 days later, after dialysis and anti-Ascaris therapy, the patient was discharged with no further complaints. Repeated controls revealed no further complaints, especially no more Ascaris lumbricoides. This case had two special aspects: (1) initial presentation with painful cervical lymph node swelling, and (2) subsequent acute renal failure. The literature revealed only four patients with Ascaris lumbricoides infection and acute interstitial nephritis, all described by one author (Zollinger). Perhaps a special hyperergic situation in this patient was responsible for the renal involvement; however, this complication should be watched for in all cases Ascaris lumbricoides infections.

Acute Kidney Injury↗
PubMed1995

Cytogenic and molecular analysis of an aggressive angiomyxoma.

Aggressive angiomyxoma is a rare mesenchymal tumor occurring mainly in the vulvar region extending into the paravaginal and perirectal region. Histologically, this tumor is rich in vascular structures and in collagen fibers and is of myxoid appearance. Cytogenetic and molecular analysis was performed on a case of an aggressive angiomyxoma and revealed clonal karyotypic abnormalities. All 50 metaphases analyzed showed a translocation involving the chromosomal region 12q14-15. Chromosomal aberrations involving the breakpoint region 12q14-15 are frequently seen in a variety of other mesenchymal tumors as uterine leiomyomas, lipomas, hamartomas of the lung, liposarcomas, or hemangiopericytomas. Therefore, this breakpoint region seems to be the most frequent chromosomal abnormality associated with the initiation of human mesenchymal neoplasms. To narrow down the breakpoint region on a molecular level in the cells of the angiomyxoma we performed FISH analysis with different cosmid clones originating from a yeast artificial chromosome and cosmid contig overspanning parts of the region 12q14-15. We were able to narrow down the region to approximately 70-80 kb belonging to an area designated a multiple aberration region, because it also includes the breakpoints of leiomyomas, lipomas, and pleomorphic adenomas with 12q13-15 abnormalities. Our molecular and cytogenic data suggest that angiomyxomas or at least a subset of them molecularly belong to the benign group of mesenchymal tumors showing multiple aberration region involvement.

Adult↗
PubMed1994

[Explosive metastasis of a cancer of the kidney pelvis in analgesic kidney].

A 48-year-old male experienced sudden pain in the right flank and macrohematuria with subsequent repeated episodes of painless macrohematuria. In the radiological work-up, CT was interpreted as inflammatory enlargement of the right kidney and MRI diagnosed renal vein thrombosis. There was some suspicion that there might be a malignancy. Five months later the patient had to be admitted to the hospital, because of increasing flank pain, desiccation and general signs of inflammatory disease. Radiological changes compatible with pulmonary metastases were found. Biopsy of enlarged mediastinal lymph nodes revealed undifferentiated carcinoma. Because of the expression of Cytokeratin primary urothelial carcinoma was suspected. The patient then deteriorated rapidly. No further specific therapy could be carried out. Death was chiefly caused by respiratory insufficiency 5 months after the first episode of pain and 1 month after admission. Autopsy revealed a poorly differentiated urothelial carcinoma of the right renal pelvis, with extensive carcinomatous angiomatosis and metastases to the left kidney, lungs, and regional and mediastinal lymph nodes. Independently of the carcinoma, both kidneys also showed interstitial nephritis, papillary necrosis and capillarosclerosis, compatible with analgesic-user kidney ("phenacetin kidney") in the absence of a corresponding history.

Carcinoma, Transitional Cell↗
PubMed1991

Pulmonary myofibroblastic nodules with "amianthoid features".

Two consecutive publications appeared 1989 in the same number of a medical journal, which reported peculiar spindle-cell tumors with dense collagen or hyaline nodules, exclusively in inguinal lymph nodes of adults. The first series of 22 cases bore the title "Palisaded myofibroblastoma, a benign mesenchymal tumor of lymph node", the second with 6 identical cases "Intranodal hemorrhagic spindle-cell tumor with "amianthoid" fibers". The following case report deals with a similar tumorous lesion, with multiple small pulmonary nodules, without recognizable lymph node constituents.

Biopsy↗
PubMed1990

Cytoskeletal heterogeneity of an epithelioid sarcoma with expression of vimentin, cytokeratins, and neurofilaments.

We studied an unusual sarcoma with morphologic features diagnostic of epithelioid sarcoma by conventional light microscopy, transmission electron microscopy, and immunohistochemistry. The primary tumor, which was located in the deep soft tissues of the buttock of a 32-year-old woman, and its metastases to lymph nodes, liver, and lung were available for investigation. The histomorphological and ultrastructural appearance of the primary tumor and its metastatic deposits were typical of epithelioid sarcoma. Immunohistochemistry revealed a strong and uniform reactivity for vimentin in both the primary tumor and its metastases. In contrast, a marked cytoskeletal heterogeneity became evident for cytokeratins and neurofilaments, which were observed exclusively in lymph node metastasis. To our knowledge, the observation of neurofilaments in epithelioid sarcoma has not previously been reported.

Adult↗
PubMed1990

[Ultrasound diagnosis of benign teratoma of the thyroid gland].

We report about a six-year old girl who underwent a hemithyroidectomy because of a teratoma in the right thyroid gland. In ultrasonography, the teratoma shows a rather well limited tumor in the right thyroid gland. It shows no signs of infiltration or compression of adjacent structures. The inner structure of the teratoma is characterized by an inhomogeneous and mixtured picture of high density echos, low density echos and areas without echos. Although the localisation of the tumor was possible by ultrasonography, the specific diagnosis of a teratoma remains difficult.

Child↗
PubMed1989

[The morphology of chemically induced kidney tumors of the rat as a model for the typing of human kidney tumors].

1. 109 renal cell carcinomas were produced in 92 Wistar rats by a single dose of 80 mg/kg diethylnitrosamine 4, 16, 24 h after partial liver resection. These tumors showed a wide variety of morphological appearances, comparable with different types of human renal cell carcinomas, as proposed by THOENES et al. in a new cytomorphological classification. However, there were striking differences as to the incidence of the individual tumors types. Whereas clear cell tumor prevailed in human they were very rare in the animal experiment. 2. 54 renal cell carcinomas were produced in 105 rats by a single dose of 30 mg/kg dimethylnitrosamine after a low-protein diet of 5 days. Also in this experiment a variety of different tumor types resulted. Already in early "tubular lesions" a strikingly elevated thymidine labelling was found, in contrast to the surrounding regular tubular epithelial cells. Moreover, topographical relations of various tumor cell types to different segments of the nephron became evident. Besides a fair number of basophilic tumors with transition into proximal tubular epithelial cells, a large number of tumors showing abundant, typically vacuolated cytoplasm became evident. These tumor cells showed in general the highest labelling index with thymidine. They apparently are related to the distal nephron and possibly constitute neoplasms of the collecting ducts, compatible with otherwise rare ductus Bellini carcinomas. Concluding, the heterogeneity concerning tumor cell types and labelling indices has to be emphasized, whereby the latter also, appear to be dependent on the vascular blood supply.

Animals↗
PubMed1988

Malignant fibrous histiocytoma. History, histology, histogenesis.

At the XVI. International Congress of the International Academy of Pathology (Vienna, 1986), a session was dedicated to the classification of soft tissue tumors. At this occasion a critical review of malignant fibrous histiocytoma (MFH) was presented. A) The history of MFH revealed that this tumor had been known for many years under a variety of names. Moreover, MFH apparently had frequently been misinterpreted as other tumor types, as for instance rhabdomyosarcoma. Today, there is a discrepancy between the high incidence of MFH among soft tissue sarcomas and its underrepresentation in some widely used tumor classifications. B) The histological appearance may be fully developed and typical for MFH. However, it also may be merely compatible with MFH in less typical tumor areas. Regional differences in morphological appearance may be pronounced. Differential diagnosis can be helped by histochemical methods. C) Histochemical methods--among others--also help to shed light on the histogenesis. More recent findings point to MFH, as a tumor of fibroblasts rather than histiocytes with similarities to loose areolar connective tissue. Although MFH-like areas may occur focally within a variety of different tumors, there remains a large group of sarcomas which do not display any signs of further differentiation even after careful work-up. In these cases the application of the term MFH, as it is understood today, appears to be justified.

Cell Differentiation↗