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Biomedical subjects

P Meier

Publications and source records attributed to P Meier.

At least 181 records · Page 10Linked to original sources
PubMed1976

[Indications for the reconstruction of the unstable thorax due to serial rib fractures and respiratory insufficiency].

Because of the impending danger of bronchopneumonial infection caused by hospital germs we consider it of utmost importance in the care and treatment of patients with instable thorax to shorten the period of intubation and artificial respiration. By stabilizing 3 or 4 chozen ribs within the flailing chest wall, we found it possible to significantly reduce the period of intubation, intensive care and hospitalisation. The splinting of several ribs individually by introducing socalled "Rehbein plates" into the medullary cavity of those in question proved to be a trustworthy method in achieving this goal.

Cross Infection↗
PubMed1975

Ascorbic acid and the common cold. Evaluation of its efficacy and toxicity.

We reviewed the clinical data relating to the efficacy and safety of pharmacologic doses of ascorbic acid in the prevention and treatment of the common cold. Although one study tentatively supports the hypothesis that such doses of ascorbic acid may be efficacious, a second study by the same group did not confirm the significant findings, and no clear, reproducible pattern of efficacy has emerged from the review of all the evidence. Similarly, there is currently little adequate evidence on either the presence or the absence of serious adverse reactions to such doses of ascorbic acid, although many such reactions have been hypothesized. The unrestricted use of ascorbic acid for these purposes cannot be advocated on the basis of the evidence currently available.

Administration, Oral↗
PubMed1975

The effects of diagnostic X-ray exposure on the human fetus: an examination of the evidence.

Epidemiological studies have demonstrated an increased incidence of morbidity and mortality among children exposed prenatally or preconceptually to diagnostic x-rays, as compared to nonirradiated controls. In those studies radiation exposure occurred on a selective basis, as the examination was always medically indicated. Comparisons of those studies and comparable ones in which radiation exposure occurred on a nonselective basis (from routine pelvimetry examinations or atomic bomb radiation) indicate that the latter studies do not confirm the former and a significant discrepancy is present in each instance. Thus, some doubt is cast on the validity of the former studies.

Child↗
PubMed1975

Statistics and medical experimentation.

Starting from a review of four major experimental areas in medicine (Polio, Coronary Surgery, Diabetes, Breast Cancer), some of the special statistical problems arising in the design and analysis of clinical experiments are reviewed, and the limitations of current formulations are emphasized. Particular attention is given to the ethical dilemma and an alternative formulation of the inference/decision problem is proposed.

Aged↗
PubMedDate not supplied

Hepatocellular carcinoma in alcoholic liver disease: no evidence for a pathogenetic role of hepatitis B virus infection.

Hepatocellular carcinoma tissues from HBsAg-negative patients with chronic alcoholic liver disease were investigated for the presence of hepatitis B virus DNA. Southern blot analyses of DNA extracted from the hepatocellular carcinomas were negative for hepatitis B virus DNA in all 17 patients examined, at a level of sensitivity of less than 0.01 genome equivalent per cell. Similarly, in liver tissues from another 30 patients with alcoholic cirrhosis without hepatocellular carcinoma, no hepatitis B virus DNA was detectable. We conclude that in our patients there is no molecular evidence for a contribution of hepatitis B virus infection to the development of hepatocellular carcinoma in alcoholic liver disease.

Adult↗