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Biomedical subjects

P McKee

Publications and source records attributed to P McKee.

25 records · Page 2Linked to original sources
PubMed1984

Angiokeratoma corporis diffusum in a patient with normal enzyme activities.

A 34-year-old man is described with angiokeratoma corporis diffusum. This eruption was once thought to be diagnostic of Anderson-Fabry disease; however, recent studies have shown that it may also occur in the enzyme disorders fucosidosis and sialidosis. In our patient with widespread angiokeratomas, the results of enzyme studies were normal, and there were no systemic problems or significant family history. Our case demonstrates that angiokeratoma corporis diffusum can occur in a benign form without systemic features.

Adult↗
PubMed1983

An immunoelectron microscopy study of the relationship between herpes gestationis and polymorphic eruption of pregnancy.

Five patients with typical bullous herpes gestationis and five patients with polymorphic eruption of pregnancy were studied. Shave biopsies were taken from both involved and uninvolved skin and examined by routine immunofluorescence. They were also examined by immunoelectron microscopy employing a multistep peroxidase-antiperoxidase technique which has been shown to be more sensitive than immunofluorescence. Despite the increased sensitivity of immunoelectron microscopy all cases of polymorphic eruption of pregnancy were completely negative. Although there is a considerable clinical and histopathological overlap between herpes gestationis and polymorphic eruption of pregnancy our findings indicate that these conditions are pathogenetically distinct and should be classified as separate disorders.

Female↗
PubMed1980

The nodular form of polymyositis--a possible manifestation of vasculitis.

A case of the nodular form of polymyositis is reported in which muscle necrosis and inflammation, and fibrosis of subcutaneous fat were observed. Although the patient had a short history, the presence of extensive fibrosis with acute lesions indicated that the disease had been present for some time. In addition to the nodular lesions, the patient had clinical, electrophysiological and pathological evidence of a more generalised myopathy. The subsequent development of a rash resembling that of vasculitis and a peripheral nerve lesion, suggested that the localised nodular myositis was associated with systemic vasculitis. Although immunoglobulin and complement deposits were not detected in blood vessel walls in muscle or skin, a positive reaction to intradermal injection of autologous serum suggested the presence of circulating immune complexes.

Adipose Tissue↗