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Biomedical subjects

P Maury

Publications and source records attributed to P Maury.

At least 37 records · Page 2Linked to original sources
PubMed1992

Influence of time of 24-hour day on depth of processing in recall memory.

In this paper we report hourly variations in recall of words in a short-term memory task. Tests were carried out at 18.00, 22.00, 02.00 and 06.00 hours. The words to be memorized were preceded by a question designed to shape the type of encoding adopted by the subjects. The question concerned semantic, typographic or structural characteristics of the word. After presentation of all the words, the subjects were tested in free recall. Time of day had no effect on overall recall scores. Nevertheless, we observed a phase difference in the recall of items processed at superficial or deep levels. Items encoded by typographical attributes were more readily recalled at 02.00 than at 18.00, whereas semantically encoded words were less well recalled at night than during the day. There was also an interaction between the serial position of the items and time of day. At 22.00 and 02.00, subjects recalled words from the end of the list better. The results are discussed in terms of resource allocation models.

Adult↗
PubMed1991

[Single-compartment arthroplasty of the knee using the Marmor-Cartier method. Apropos of a series of 100 cases].

100 unicompartmental knee prosthesis type Marmor-Cartier with 86 replacements of the medial compartment have been followed for a period of 5 to 15 years. Contrary to the reaxation osteotomies, a moderate hypocorrection about 3 to 5 degrees has to be respected in unicompartmental knee replacement. The two major complications are degradation of the contralateral compartment due to hypercorrection; and loosening of the tibial plateau due to hypocorrection over 5 degrees or anterior laxity or convex side laxity or misalignment of the prosthetic device. The unicompartmental knee arthroplasty is a trustful surgical procedure as long as precise indications for this method and a rigorous surgical technique are respected.

Adult↗
PubMed1980

Variation of urinary excretion of aspartylglucosamine and associated clinical findings in aspartyglucosaminuria.

The urinary excretion of aspartylglucosamine (AADG), the main accumulating glycoprotein degradation product in aspartylglucosaminuria (AGU), was studied in 40 patients at various stages of the disease. Only slight variation was found when the amount of AADG excreted by ten AGU patients under 10 years of age was compared with AADG excretion of older patients at a clinically advanced stage of the disease. The 24h AADG excretion of the younger patients was 354 mg compared with 441 mg in the group of ten patients over 20 years of age. Clinical symptoms were unrelated to AADG excretion.

Amidohydrolases↗
PubMed1980

Characterization of the storage material of peripheral lymphocytes in aspartylglycosaminuria.

1. Aspartylglycosaminuria is a neurovisceral storage disease characterized by reduced or absent activity of the lysosomal enzyme N-aspartyl-beta-glucosaminidase. Although vacuolization of peripheral lymphocytes is a well-documented feature of aspartylglucosaminuria, the chemical composition of the lymphocyte storage material is not known. In this paper we describe the results of glycopeptide analyses of peripheral lymphocytes isolated from the blood of a 29-year-old female patient with aspartylglycosaminuria and from a control subject. 2. By use of a highly specific and sensitive gaschromatographic-mass-spectrometric technique, 4-N-2-acetamido-2-deoxy-beta-D-glycopyranosyl-L-asparagine (N-acetylglucosaminylasparagine) was found to accumulate in the patient's lymphocytes, but not in those of the control subject. 3. The amount of this compound stored in the diseased lymphocytes was found to be approximately 2.3 nmol/100 microgram of soluble protein. 4. We suggest that this compound is the main storage substance in the peripheral lymphocytes in aspartylglucosaminuria and that it is probably responsible for the cytoplasmic vacuolization of these cells.

Acetylglucosamine↗
PubMed1979

Accumulation of two glycoasparagines in the liver in aspartylglycosaminuria.

Two water-soluble glycoasparagine storage products were isolated from the liver of a patient with inherited deficiency of lysosomal N-aspartyl-beta-glucosaminidase (aspartylglycosaminuria). The compounds were characterized using gas chromatographic-mass spectrometric analyses of intact and specifically degraded derivatives. The storage compounds were identified as 2-acetamido-1-N-(4'-L-aspartyl)-2-deoxy-beta-D-glucopyranosylamine and alpha-D-mannopyranosyl-(1 leads to 6)-beta-D-mannopyranosyl-(1 leads to 4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1 leads to 4)-2-acetamido-1-N-(4'-L-aspartyl)-2-deoxy-beta-D-glucopyranosylamine. Their amounts in the pathological liver were approximately 2.7 mg/g and 0.2 mg/g, wet weight, respectively. These glycoasparagines are structurally related to the inner core region of a number of different glycoproteins.

Asparagine↗
PubMed1979

Identification of 4-N-2-acetamido-2-deoxy-beta-D-glucopyranosyl-L-asparagine in biological materials by gas chromatography-mass spectrometry.

A specific and sensitive method for the identification of 4-N-2-acetamido-2-deoxy-beta-D-glucopyranosyl-L-asparagine (GlcNAc-Asn) in urine in aspartylglycosaminuria and in hydrolysates of glycoproteins is described. The method involves permethylation of GlcNAc-Asn followed by gas chromatographic-mass spectrometric analysis of the methylated derivative. It can be used to confirm the diagnosis of aspartylglycosaminuria and to assess the excretion of GlcNAc-Asn in urine during various phases of the disease. The presence of an N-acetylglucosaminyl-asparagine type of carbohydrate-peptide linkage in a glycoprotein can be determined by applying the method to the partial acid hydrolysate of a proteolytically digested glycoprotein.

Acetylglucosamine↗
PubMed1979

Quantitative determination of 4-N-2-acetamido-2-deoxy-beta-D-glucopyranosyl-L-asparagine in the urine of patients with aspartylglycosaminuria by gas-liquid chromatography.

A specific and sensitive method for the quantitative ;determination of glcNAc-Asn in the urine of patients with inherited deficiency of the lysosomal hydrolase N-aspartyl-beta-glucosaminidase is reported. The method is based on GLC assay of GlcNAc-Asn as its methylated derivative and requires 100 microliter of urine. The mean urinary excretion of GlcNAc-Asn in 14 AGU patients was 0.99 mmol/24 hr (range 0.15 to 1.88). Young patients had similar urinary levels of GlcNAc-Asn to those of the older ones when the results were calculated on the basis of creatinine excretion. Mass fragmentographic analysis revealed the presence of minimal amounts of GlcNAc-Asn in normal urine also. In four of the eight normal subjects studied, a rough quantitative estimation was feasible; the urinary output of GlcNAc-Asn in these subjects ranged from approximately 0.001 to 0.01 mmol/24 hr.

Acetylglucosamine↗
PubMed1978

Increased excretion of two sialic acid-containing trisaccharides in the urine of patients with rheumatoid arthritis.

The urinary excretion of sialic acid-containing trisaccharides in patients with active rheumatoid arthritis was studied. Sialyl-lactose and sialyl-N-acetyllactosamine were identified and their excretion patterns studied by thin layer and gas chromatography. The urinary output of sialyl-lactose was greater in patients with active rheumatoid arthritis (48.2 +/- 6.1 mg/24 h, SEM, n = 6) than in healthy subjects (19.8 +/- 3.7 mg/24 h, SEM, n = 5; P less than 0.01). The excretion of sialyl-N-acetyllactosamine was also higher in the rheumatoid group (18.5 +/- 2.1 mg/24 h, SEM, n = 6) than in the controls (11.1 +/- 1.2 mg/24 h, SEM, n = 5; P less than 0.05). The qualitative excretion patterns of the sialyl-oligosaccharide fraction were similar for the two groups as judged from the thin layer chromatograms. Correlating the results with the clinical state of the patients with rheumatoid arthritis suggests that the urinary level of the sialyl-oligosaccharides reflects the activity of the disease. A proposed mechanism for the increased excretion of sialic acid-containing trisaccharides in rheumatoid arthritis is presented.

Adult↗
PubMed1978

Blood cadmium level and hypertension in humans.

Blood cadmium level was determined in 29 nontreated hypertensive male subjects and 29 controls. All were individually matched for sex, age, and smoking habits. No differences were found between hypertensives (3.3 +/- 0.4 ng/ml) and normotensives (2.6 +/- 0.4 ng/ml).

Adult↗