Search PubMed⌕ Search

Biomedical subjects

P Maurice

Publications and source records attributed to P Maurice.

At least 145 records · Page 8Linked to original sources
PubMed1976

[Atrial spetal defects of the ostium secundum type with mitral valve insufficiency. Apropos of 31 cases].

31 cases of ASD with mitral incompetence have been reviewed. The aetiology of the mitral incompetence is most frequently congenital, contrary to the classical view. The usual mitral defect is a combination of gaping of posterior commissure with a narrow valvular opening. The usual angiocardiographic picture is one of prolapse of the mitral valve. One of the characteristic findings, which has already been reported in the literature, is of redundant valve tissue, with myxomatous degeneration (one case confirmed histologically). Surgery is indicated in every case. Conservative mitral surgery gives satisfactory results in the mid-term.

Angiocardiography↗
PubMed1976

[Long-term fate of mitral valve prostheses].

The long term fate of mitral valve replacements (over 2 years) has been studied by the collection of information from many French cardiology centres. The Starr valve with a plastic ball-valve is by far the most commonly used prosthesis. The late complications are dominated by thrombo-embolic sequelae. The functional result seems to be proportionally better the earlier the stage at which the operation is carried out.

Adolescent↗
PubMed1976

[Valve replacement by ball prosthesis. Study of risk factors].

245 patients had consecutive operations for replacement of a valve by a ball-valve prosthesis in the aortic position (114) in the mitral position (91), or in more than one position (40) between 1970 and March 1973. The operative mortality was 14.3% (9.5% if emergency operations are excluded). A statistical study of the risk factors has shown the relatively minor influence of the patients' preoperative status (age, NYHA functional classification, cardiomegaly, mean pulmonary arterial pressure, mean capillary pressure) and of the conditions during surgery (duration of extacorporeal circulation, size of the prosthesis). The majority of the early deaths (19 deaths out of 35) occur as part of a syndrome of low cardiac output (9) and/or of a severe disorder of ventricular rhythm (11). 9 of the 14 post-mortem examinations on such patients showed a haemorrhagic subendocardial lesion and/or, in 4, an intracardiac thrombosis on the prosthesis. The coronary arteries were normal (14), or slightly atheromatous (1). The histological picture is one of a haemorrhagic interstitial infiltration mainly in the subendocardial layers. The late failures (secondary deaths and poor results) are essentially related with poor preoperative status (age, functional classification, cardiothoracic ratio) or with complications which would be treatable given proper and regular follow-up supervision of the patients (porsthesis which pulls away or fails to function, thromboembolic accident, coronary complication).

Female↗
PubMed1976

[Hemodynamic effects of intravenous injections of amiodarone chlorhydrate in normal subjects and coronary patients].

A study has been made of the haemodynamic affects of a single intravenous injection of amiodarone chorhydrate (5 mg/kg); the injection was given at rest to six normal subjects and six patients with coronary insufficiency due to atherosclerosis. The effects of the drug are most marked at the fifteenth minute after injection, and are: slowing of the heart rate; lessened cardiac output and left ventricular effort; a significant increase in mean pulmonary arterial pressure and diastolic pressure; slight variations in flow in the coronary sinus, with an increase in the ratio of coronary sinus flow to cardiac output. Amiodarone chlorhydrate appears to exert a favourable action upon the heart because, while it maintains myocardial perfusion, it tends to diminish the myocardial oxygen requirement by decreasing the rate of contraction and the contractility of the myocardium.

Adult↗
PubMed1975

[The treatment of myeloproliferative syndromes].

A review is presented of the clinical, physiopathological and therapeutic aspects of four varieties of chronic myeloproliferative syndrome: polycythemia vera, idiopathic thrombocythemia, chronic myelocytic leukemia and idiopathic myeloid metaplasia. Routine and experimental therapeutic approaches are discussed.

Aged↗
PubMed1975

Comparison of the combination of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and vincristine with two dose schedules of 5-(3,3-dimethyl-1-triazino) imidazole 4-carboxamide (DTIC) in the treatment of disseminated malignant melanoma.

One hundred twenty patients with inoperable metastatic malignant melanoma were randomly allocated to treatment with either a combination of BCNU 150 mg/m2 and vincristine 2 mg/m2 given every 30 days, or one of two regimens of DTIC: 300 mg/m2/day x 6 or 100 mg/m2/8 hours x 18 given every 30 days. Eight of the 51 (16%) patients who were originally treated with the BCNU and vincristine combination had 50% or more objective tumor regression, compared to 6 out of 25 (24%) patients treated with daily injections of DTIC, and 6 out of 21 (29%) patients treated with DTIC injections every 8 hours. The median duration of response to the BCNU and vincristine combination was 60 days, and the median duration of survival from initiation of treatment was 6.5 months in the responders and 3.3 months in the nonresponders. The median duration of response was 90 and 100 days for the daily and 8-hour regimens of DTIC respectively, andthe median duration of survival from commencement of treatment was 8.5 months for the responders and 3.5 months for the nonresponders. None of the 43 patients who failed to respond to the initial treatment program or whose disease progressed after initial improvement responded to the alternate treatment regimen.

Adult↗
PubMed1975

[Course of telesystolic mitral insufficiency. Apropos of a case followed for 7 years and operated on].

One case followedup for 7 years with progressive intensification of regurgitation, requiring a surgical operation at the age of 48 years, brings its contribution to knowledge of the natural history of late systolic mitral incompetence and of the anatomical lesions causing it. The presence of prolapsed posterior leaflet, of stretched chordae tendinae, of both septal and parietal muscle hypertrophy with biloculation of the ventricular cavity were suggested by angiocardiography and confirmed by operation. A review of the literature reporting the cases with operative or post-mortem verification poses the unresolved question of the diagnostic criteria of late systolic mitral incompetence at the stage of cardiac failure.

Adult↗
PubMed1975

[Unruptured aneurysms of Valsalva sinus of septal origin].

Aneurysms of Valvsalva sinus unruptured into a cavity, but developing into the membranous and even muscular interventricular septum are exceptional. Two cases illustrating this fact are reported. In one of them, a massive mitral incompetence by elongated chordae tendinae related to the presence of a voluminous intra-septal pouch. Atrio-ventricular and intraventricular conduction disturbances were present in both patients. The interest of supra-valvar angiography which makes it possible to advise operation before the eventual rupture is underlined.

Adult↗
PubMed1975

[Study of interventricular septal defects with equal aortic and pulmonary artery pressures. Classification by clinical and computer methods of 70 cases].

Application of various methods of classification to a group of 70 cases of ventricular septal defect with high pulmonary artery hypertension allowed a comparative study between the various methods aiming at distinguishing the forms with low from high pulmonary artery resistance. The reference clinical classification provides supplementary informations derived from the natural or post-operative course and eventually from the microscopic examination. The first automatic classification relies on the study of a single criterion: the pulmonary arteriolar resistance and the systemic resistance ratio. A second classification is based on the attribution of points to some clinical or haemodynamic signs resulting in a score orienting the classification of every individual. Multifactorial analysis methods deal with all the available informations for the overall group, and suppose the use of a computer. The informatic methods make it possible to study the classifying value of every sign. Correlations were established between these various techniques and the medical classification.

Adolescent↗
PubMed1975

[Transposition of great vessels with pulmonary stenosis and interventricular communication. Anatomic and surgical aspects. Apropos of 10 cases].

10 cases of anomalous position of the great vessels are reported. They include 8 cases of d-transpositions, 1 of 1-transposition and 1 anatomically corrected malposition. These cases have in common the combination of a ventricular septal defect with a pulmonary stenosis. The anatomical study (6 of 10 cases) made it possible to describe the type of the VSD (related to a defect of development and/or alinement of parietal on the septal band) and of the pulmonary pathway stenosis. Blalock's anastomosis has made it possible to obtain an improvement in 6 patients. 4 operations of complete cure were undertaken in d-transpositions: 2 Mustard's operations ending in death. 2 operations according to Rastelli's principles with one death and one good result. The case of anatomically corrected malposition died after an attempt at complete cure, in view of a left ventricular hypoplasia. The indication for the type of complete cure was discussed in relation with the anatomical data.

Blood Pressure↗
PubMed1975

[Upward displacement of the ST segment of an exercise electrocardiogram. Correlation with coronarography].

7 cases with upward displacement of the R-ST segment in the course of effort were compared with the data derived from the coronary arteriography. The lesions were found to be severe in 4 cases, mildly significant or not at all so, in 3 cases. The sub-epicardial lesion on effort, as Prinzmetal's angina, does not make it possible to foresee the degree of the responsible stenosis, which may vary through a superadded spasm, and encourage to undertake an aorta-to-coronary artery by-pass.

Adult↗
PubMed1975

[Left juxtaposition of the atria. Apropos of a case with dextroversion, transposition of great vessels, bilateral conus, interventricular communication and pulmonary atresia].

Report of one case of a woman aged 29 years with a severe cyanotic congenital heart disease complicated by brain abscess. The diagnosis of left juxtaposition of the atria combined with dextroversion, a d-transposition of the large vessels and a vestricular septal defect was done pre-operatively. An attempt at a Rastelli's operation was followed by immediate death. The post-mortem examination confirmed the pre-operative diagnosis and demonstrated besides a double conus and a pulmonary atresia. The juxtaposition of the atria was underlined.

Adult↗