Physical training in patients with ventricular dysfunction: choice and dosage of physical exercise in patients with pump dysfunction.
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Heart Diseases↗
Biomedical subjects
P Mathes
Publications and source records attributed to P Mathes.
The influence of the type of occupation on return to work after myocardial infarction, coronary angioplasty and coronary bypass surgery.
Between January 1980 and December 1983 the medical and social status of 423 patients who were considered candidates for aortocoronary bypass surgery (ACBS) was assessed by a questionnaire, at a mean of 16 months after coronary angiography. Of these patients 54 had refused surgery, 15 were re-operated, 23 had angioplasty and seven had died on the waiting list. After exclusion of these 117 patients, 306 remained, who form the basis of this report. Fifty three patients (17%) had retired before surgery, four (1.3%) had died perioperatively and 19 were on sick-leave for less than three months. Of those who were still employed pre-operatively, 102 (44.3%) went back to work, 85 (37%) had retired and 42 (18%) were on sick-leave for longer than three months. Significant differences were noted between the 102 working and the 85 retired patients as far as medical and social factors are concerned. Of the medical factors, post-operative freedom of symptoms (P less than 0.0001), postoperative exercise tolerance (P less than 0.0001) and completeness of revascularization (P less than 0.05) seemed to have influence on return to work. Of the social factors, age (P less than 0.0001), type of occupation (P less than 0.0002), duration of preoperative absence from work (P less than 0.001) and heavy manual work (P less than 0.05) showed significant differences between the groups. Since duration of preoperative absence from work is the only preoperative factor that can be modified, strategies for improving the return-to-work rate should aim at the shortening of waiting times for coronary angiography and ACBS.
Angioplasty, Balloon↗
Indications for and contraindications to training in angina pectoris.
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Angina Pectoris↗
Noninvasive detection of anterior wall asynergies by cardiokymography compared to electrocardiography.
In order to determine the value of cardiokymography in detecting left ventricular (LV) anterior wall asynergies, 80 consecutive patients had a cardiokymogram (CKG) and an electrocardiogram (ECG) on the day prior to coronary angiography. Technically adequate CKGs were obtained in 72 patients (67 men and 5 women, mean age 53 +/- 6.5 years). For validation of regional contraction abnormalities, quantitative LV angiography was used. Stepwise linear discriminant analysis was applied to investigate the diagnostic power of CKG. Sensitivity of the CKG for LV anterior wall asynergy was 67.9% (ECG: 39.6%) and specificity was 68.4% (ECG: 94.7%) on the basis of 1 SD of the mean values of the radial axis shortening of a control group. For 2 SD, the sensitivity was 65.6% (ECG: 56.3%) and the specificity 47.5% (ECG: 90%). By combined testing, the specificity increased to 98.3%, whereas the sensitivity dropped to 26.9%. The improvement of the post-test likelihood for a positive ECG by a positive CKG is especially pronounced in the intermediate prevalence range, whereas for a negative ECG the post-test likelihood can be further decreased by a negative CKG in the intermediate and high prevalence range. The ECG as a single test seems to be the more appropriate noninvasive method for detecting LV anterior wall asynergies; however, the combined use of both ECG and CKG may considerably improve the diagnostic accuracy.
Cineangiography↗
The effect of coronary revascularization on exercise-induced ventricular arrhythmias.
From the data available so far it is apparent that in patients with stable angina, bypass graft surgery is not associated with any change in ventricular premature complexes or complex ventricular arrhythmias at rest or during exercise over a 1-5 year follow-up period despite the evidence of a substantial relief of exercise-induced ischaemia persisting for 5 years. In addition, ventricular arrhythmias are not predictive of sudden death except in a few patients, in whom ventricular tachycardia or ventricular fibrillation during exercise-induced ischaemia could be documented. Such exercise-induced arrhythmias appear to have a poor prognosis, unless the ischaemia is relieved by bypass surgery. The available literature suggests that ventricular arrhythmias at rest or during exercise in patients following bypass surgery are not related to ischaemia but to other unknown factors. Electrical instability during exercise may be caused by other factors rather than by ischaemia, and this phenomenon should be further investigated.
Arrhythmias, Cardiac↗
Arrhythmogenic potential of exercise-induced myocardial ischaemia.
In a series of 300 patients following transmural infarction undergoing coronary angiography because of ischaemia in the surviving myocardium, 17 demonstrated an exercise response indicative of myocardial ischaemia in the absence of angina pectoris. The presence of ischaemia in the region of the myocardium under scrutiny was proven by: (1) ST-segment depression during bicycle-ergometry of at least 2 mm in leads without any QRS or ST-T changes at rest. (2) greater than 75% stenosis of vessels supplying the area under investigation, in addition to the vessel supplying the region of the infarction. (3) A reversible Thallium-perfusion defect on exercise. We compared those 17 patients with silent myocardial ischaemia with 21 patients with typical angina pectoris on exertion. All patients underwent 24-hour Holter monitoring, treadmill exercise testing at a target heart rate previously determined as inducing signs of myocardial ischaemia, and swimming and calisthenic programs with telemetric ECG recording. There was no close relationship between myocardial ischaemia and the occurrence of complex ventricular arrhythmias. In silent ischaemia complex ventricular arrhythmias do not occur at a higher rate than in patients with angina pectoris.
Angina Pectoris↗
Arrhythmogenic potential of silent myocardial ischemia following transmural myocardial infarction.
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Arrhythmias, Cardiac↗
[Non-secreting myeloma. Case report with immunohistologic and electron microscopic studies].
Immunological, immunofluorescence and electromicroscopic studies were performed in a case of atypical myeloma. The 77-year-old patient presented with skeletal pain, multiple osteolytic lesions and bone marrow infiltration by atypical plasma cells. Monoclonal light chains kappa were confined to the plasma cells, as shown by immunofluorescence. No monoclonal immunoglobulin or fragments were detected in plasma or concentrated urine, even by highly sensitive immunological methods. The concentration of the immunoglobulins G, A and M in the plasma was markedly reduced. The plasma cells contained very little sarcoplasmatic reticulum. The simultaneous occurrence of monoclonal light chains kappa in the plasma cells and the absence of monoclonal immunoglobulins or fragments in plasma and urine suggest a non-secretory myeloma.
Diagnosis, Differential↗
[Value of inpatient rehabilitation measures following myocardial infarct].
The primary goal of rehabilitation is to slow down the progression of coronary heart disease via secondary preventive efforts and to reduce the negative social and psychosomatic sequelae of a myocardial infarction to the unavoidable minimum. Cardiac rehabilitation has developed into an active strategy of secondary prevention, based on sufficient diagnostic evaluation, aiming at the modification of risks factors and including the entire psychosocial field into the long-term therapeutic concept. After myocardial infarction the patient carries, in comparison to the normal population, approximately a tenfold risk to die suddenly or to suffer another myocardial infarction. Following a first infarction, risk factors such as smoking, hypercholesterolemia and hypertension are of increased epidemiologic importance. A lower social class will in itself lead to an increase of the incidence of reinfarction and to a decrease in life expectancy. One of the central goals therefore is to convey the importance of a health-oriented behavior pattern, which is achieved in single and group-therapy sessions as well as with the help of physiotherapy. Controlled physical exercise, however, does not only serve as an educational vehicle, but also has direct effects on cardiovascular physiology, leading to a decrease in heart rate and blood pressure for a given work load and thus to an increase of the angina pectoris threshold. Moreover, controlled physical exercise has a substantial antidepressive effect in the critical phase following acute myocardial infarction, and will lead to increased self-confidence.(ABSTRACT TRUNCATED AT 250 WORDS)
Adaptation, Psychological↗
[Mitral valve insufficiency in coronary heart disease].
On 121 consecutive patients with coronary heart disease coronary angiography and quantitative left ventricular angiography was done with the view to aortocoronary bypass surgery. 24 (20%) had mitral regurgitation (MR) by angiographic criteria, 20 of them had MR grade I/IV, four had MR II/IV. In 23 out of 24 patients with MR quantitative left ventriculography revealed localized contraction disorders. MR was clinically diagnosed in 15 out of 24 patients. In eleven patients (48%) contraction abnormalities were localized in the inferior wall, in five cases (22%) in the anterior wall and in seven cases (30%) both in the anterior and posterior wall. Of the latter group patients with MR showed a significantly lower ejection fraction than patients without MR (p less than 0.05). Furthermore the MR-group showed larger akinetic areas, preferentially located in the inferior segments 0 degrees-240 degrees and in the anterolateral segments 60 degrees-90 degrees. Three vessel disease was more frequent in this group (43%) than in the group without MR (23%). Patients with inferior wall asynergy frequently showed combined stenosis or occlusion of the right and circumflex coronary artery. In conclusion, MR in coronary heart disease is most often associated with localized contraction disorders of the left ventricle; posterior wall infarctions, multiple vessel disease and large akinetic areas are more frequent. However, the hemodynamic significance of MR in patients with chronic myocardial infarction is usually insignificant.
Coronary Angiography↗
[Diagnosis after recent myocardial infarct].
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Echocardiography↗
[Electrocardiogram and M-mode echocardiography in the diagnosis of chronic transmural infarct. Correlations and determination of the accuracy of both methods based on quantitative levocardiography].
In a comparative study of 121 consecutive patients who had had coronary angiography for coronary heart disease, the diagnostic informations obtained by M-mode echocardiography and electrocardiography in chronic transmural infarction were compared. Wall excursion by echocardiography did not allow sufficient separation of normal and asynergic segments. Changes in systolic wall thickness, on the other hand, provided satisfactory sensitivity and good specificity in the recognition of segmental contraction disorders: posterior wall thickening of 0.64 and 0.76, respectively, septal thickening of 0.45 and 0.91, respectively. In 53% of patients the ECG and echocardiogram provided findings similar to those by angiography. False-positive findings occurred in 10% of electrocardiograms, 14% of echocardiograms. False-negative findings in the ECG occurred in 13%, in the echocardiogram in 25%. Both methods combined had a specificity of nearly 100% with regard to the diagnosis of posterior-wall and anterior-wall infarction, and a positive predictive value of 0.92 (posterior) and 0.93 (anterior wall infarction). M-mode echocardiography and ECG findings provide reliable diagnosis of both the anterior and posterior wall chronic transmural infarction.
Adult↗
[Qualitative and quantitative analysis of regional contraction disorders using levocardiograms].
In 74 patients with proven myocardial infarction (typical history and enzymes, diagnostic ECG, and stenosis of the vessel supplying the asynergic region of more than 75%) the results of qualitative analysis of left ventricular cineangiograms were compared to those of quantitative analysis using the radial axis method of Mathes. There was a significant difference in interpretation between the two methods if the physiological movements of the heart were not taken into account in the qualitative analysis. After correction for systolic anterior movement and downward movement of the aortic valve during systole, a mean accuracy of 92% resulted. The radial axis method discriminated well between normokinetic and asynergic wall segments. However, this method proved less useful for the detection of asynergies in the apical, anterobasal, and posterobasal regions. A radial axis angle of between 15 degrees and 20 degrees is considered to be optimal. The quantitative analysis seems to be particularly useful for the interpretation of borderline cases, and should be carried out routinely in addition to the qualitative analysis.
Adult↗
[Significance of the E point-septum distance for the evaluation of left ventricular function in coronary disease--a study using M-mode echocardiography].
In 121 patients (pts) with angiographically proven coronary artery disease, left ventricular (LV) cineangiograms were quantitatively evaluated. 79 pts showed regional wall abnormalities. In this group the relationship between echocardiographic parameters of global (LV) function (mitral-septal separation, systolic and diastolic diameter, and fractional shortening) and ventriculographic parameters was investigated. Mitral-septal separation showed the best correlation to the angiographic ejection fraction (EF) (r = -0.72). The measurement of this parameter allows the diagnosis of a reduced EF independently of the dilatation of the left ventricle, and is easy to perform and to reproduce. Mitral-septal separation discriminated well between the reference group and all infarction subgroups (posterior wall, anterior wall, and double infarction) with reduced EF. The modification of the mitral-septal separation measurement according to D'Cruz et al. showed no advantage over that proposed by Massie et al. Both are clearly dependent upon septal excursion, which has to be taken into consideration when mitral-septal separation is being evaluated. The sensitivity of mitral-septal separation (greater than 7 mm) for the detection of reduced LV function (less than 55%) was 0.66; the specificity was 0.80. There was greater sensitivity for anterior wall infarctions than for posterior wall infarctions (0.73 vs 0.44). Because of the relatively high number of false negatives, only a pathologic mitral-septal separation is diagnostically useful.
Adult↗
[Report on a successful orthotopic cardiac transplantation in Germany].
The first successful heart-transplantation carried out in the Department for Cardiovascular Surgery of the University of Munich, Klinikum Grosshadern is reported. The recipient, 32 years old at the time of operation, had sustained a large antero-lateral-septal myocardial infarction in June 1980; thereafter the left ventricular ejection fraction was severely impaired (e.f. = 19%). Yet, the operation was definitely planned some year later, after the patient had survived an embolus to the right lung, an acute left heart failure and a small ulcer of the stomach. The operation was performed on 8-19-1981. The donor was a 23 year old young man, who had met a fatal motorcycle accident 10 days ago. The man was pronounced dead in the afternoon of the preoperative day according to the criterions of the German Society for Surgery by means of a carotid angiogram. Donor and recipient were well matched in regard to blood group, HLA-A2-System and finally cross-match-test. Transplantation was carried out according to the technique of Lower and Shumway. Immediately p.o., immunosuppressive therapy was started using azathioprine, cortisone and antihuman thymocyte globulin. Two acute rejections were noted, the first from p.o. day 6 to 15, the second from p.o. day 22 to 34. The second acute rejection was complicated by a pneumatosis cystoides intestinii, which caused a change of the immunosuppressive therapy to Cyclosporin A. No further complications were registered in the following p.o. course, the patient is discharged since Christmas 1981.
Adrenal Cortex Hormones↗
[Electrocardiography and quantitative levocardiography in chronic transmural infarct. A correlative study].
For evaluation of a connection between the electrocardiographic diagnosis and localisation of chronic infarction and the angiographic results left ventriculography data of 97 patients with coronary heart disease were assessed quantitatively according to the method of Mathes. According to electrocardiographic criteria of infarction six subgroups were distinguished: anteroseptal, anterior, anterolateral, inferior, inferiolateral, and posterolateral. Asynergies were demonstrable in 87% of patients with infarct electrocardiograms, normal ventricular function was seen in 80% of patients without infarct ECG. Asynergies were seen in 75% of electrocardiographically diagnosed anterior wall infarcts and in 92% of posterior wall infarcts. The sensitivity of the ECG in chronic infarction was 83%, the specificity 84%. Pronounced differences in the number of involved segments were found between inferior and inferiolateral infarction. In contrast, no clear-cut differentiation of electrocardiographic findings judged by segmental involvement in the left ventriculography was seen for the anterior wall. The extent of the anterior wall infarction diagnosed by electrocardiography did not correlate with results of left ventriculography. The ECG is a suitable means for detection of segmental disturbances of contraction also in the chronic infarction stage. However, localisation and extent of the lesion can only be assessed within limits.
Angiocardiography↗
[Post-infarction ventricular function in relation to the contractility of the remaining myocardium (author's transl)].
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Angiocardiography↗
[Initial systolic ejection rate as a parameter of ventricular function in valvular heart disease (author's transl)].
In patients with valvular heart disease the initial systolic ejection rate was determined in an attempt to characterize ventricular function in pressure and volume overload. By means of left ventricular cineangiography, the volume change during the initial third of the ejection phase was determined and the mean ejection rate of this period was calculated. A total of 40 patients were examined, 7 patients without heart disease, 15 patients with pure aortic regurgitation, 9 patient with pure aortic stenosis and 9 patients with pure mitral regurgitation. In patients with pure aortic regurgitation and high-normal values for ejection fraction and mean velocity of circumferential fiber shortening (mVcf) a significant increase in initial systolic ejection rate when compared to the group of normals was observed. The distribution of the stroke volume for each third of the ejection phase corresponded to the normal pattern. In contrast, in patients with low-normal values for ejection fraction and mVcf, a decrease in the initial systolic ejection rate below the normal value was observed, along with a pathological distribution of the stroke volume during the ejection phase. This finding was also noted in all patients with pure mitral regurgitation and pure aortic stenosis. In aortic stenosis, the decline in initial systolic ejection rate was regarded as a consequence of the outflow tract obstruction, whereas in volume overload, this was regarded as a sign of a decline in ventricular function which is not recognized with global parameters such as ejection fraction and mVcf.
Angiocardiography↗