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Biomedical subjects

P Massin-Korobelnik

Publications and source records attributed to P Massin-Korobelnik.

7 recordsLinked to original sources
PubMed1995

Acute posterior multifocal placoid pigment epitheliopathy after hepatitis B vaccine.

OBJECTIVE: To report two cases of acute posterior multifocal placoid pigment epitheliopathy after immunization with a recombinant hepatitis B virus vaccine. DESIGN: Case reports. RESULTS: Two patients had development of visual loss 3 days to 2 weeks after the booster administration of 20 micrograms of recombinant hepatitis B virus surface antigen (Engerix-B). In both cases, fundus examination, fluorescein angiograms, and the course of the disease were typical of acute posterior multifocal placoid pigment epitheliopathy. In case 1, 1 week after immunization, the leukocyte count was 10.3 X 10(9)/L with 24% polynuclear eosinophils (2.47 X 10(9)/L); in case 2, blood cell counts were normal. CONCLUSION: Hepatitis B virus immunization may be a risk factor for acute posterior multifocal placoid pigment epitheliopathy. Molecular mimicry between a retinal pigment epithelium protein and hepatitis B surface antigen could play a role. These cases suggest an immune-mediated retinal pigment epithelium disruption or choroidal vascular occlusions triggered by hepatitis B surface antigen.

Acute Disease↗
PubMed1994

Spontaneous evolution and photocoagulation of diabetic cystoid macular edema.

Cystoid macular edema (CME) causes progressive visual impairment in diabetic patients and its treatment by photocoagulation remains unsatisfactory. We observed its spontaneous evolution for 3 years in 31 eyes. CME resolved in 9 eyes, was fluctuant in 16 and worsened in 7. Mean group visual acuity (VA) remained unchanged. Two modalities of photocoagulation were studied. In 27 eyes exhibiting CME combined with circinate exudates (group 1), extramacular focal photocoagulation was applied to the center of the exudates. Exudates disappeared from 23 eyes and CME from 12 eyes. Mean group VA remained unchanged. In 24 eyes with CME but without exudates (group 2), perifoveolar grid photocoagulation was applied over the CME area. CME disappeared from 15 eyes. Mean VA remained unchanged. These results show that CME with exudates requires a two-step treatment, comprising first focal photocoagulation, which clears exudates and often improves CME, and second--but only if CME persists and VA is below 0.5- perifoveolar grid photocoagulation, which often clears CME and stabilizes VA.

Adult↗
PubMedDate not supplied

[Classification and outcome of diabetic retinopathy].

Several classifications of diabetic retinopathy have been proposed. The most recent, used in the DRS and the ETDRS, are grading systems, based on the comparison of stereoscopic fundus photographs with color photographic standards. Fluorescein angiography is not used, and the DRS and ETDRS classifications are too complex for routine evaluation. Classifications using standardized vocabulary should provide more accurate assessment of diabetic severity and prognosis.

Diabetic Retinopathy↗
PubMedDate not supplied

[Treatment of diabetic retinopathy by photocoagulation. Indications, methods and results].

The beneficial effects of Argon laser panretinal photocoagulation for diabetic retinopathy complications in decreasing the incidence of blindness were established almost twenty years ago by a multicentric study (Diabetic Retinopathy Study). Every eye presenting with neovascular proliferation either on the disc or elsewhere should be treated with panretinal photocoagulation. Diabetic maculopathy, and mainly cystoid macular edema is the main cause of visual loss in diabetic patients. Photocoagulation in the macular area has proven to be effective in the treatment of exudate rings and cystoid macular edema. Visual acuity is either stabilized or improved after Argon laser treatment of diabetic maculopathy.

Diabetic Retinopathy↗
PubMedDate not supplied

[Diabetic maculopathy:classification, epidemiology, spontaneous outcome, treatment].

Macular edema is the main cause of visual impairment in diabetic patients. It occurs in about 10% of the diabetic population and in 30% of patients with up to twenty years of diabetes. Macular edema usually progress very slowly. Several studies have shown that almost 50% of the eyes affected displayed no change in vision during a two-year follow-up. Macular edema may spontaneously resolve, and probably responds to correction of glycemic and systemic anomalies, thus indicating that it does not require urgent treatment. The treatment of macular edema is based on argon green laser photocoagulation. Extra macular focal photocoagulation delivered to the center of circinate exudates results in exudate resorption and is indicated when ever the exudates enter the macular area. The treatment of cystoid macular edema consists of grid photocoagulation in the perifoveolar area. In most cases, it results in the disappearance of CME and visual stabilization, but rarely in visual improvement.

Diabetes Mellitus, Type 1↗