Search PubMed⌕ Search

Biomedical subjects

P Martinić

Publications and source records attributed to P Martinić.

8 recordsLinked to original sources
PubMed1981

[Congenital factor X deficiency, the Prower-Stuart deficiency].

The congenital deficit of factor-X is extremely rare and usually goes with mild bleeding tendency. The variations of the factor-X activities are described individually and depend on the tests used, that is: activating factor-X by tissue or blood thromboplastin, Russel's Viper Venom, by neutralisation of the antibodies or immunoprecipitation. The test depends on the possibility of the specific congenital deficient plasma or on the use of the filtered bovine plasma. That's why it is rather difficult to classify the cases and order the minimum of the hemostatic level. Besides a short description of some physical, chemical and biochemical characteristics of factor-X, present the case with congenital deficit of Prower-Stuart factor discovered in our laboratory, together with the findings and procedures in identifying and confirming it.

Aged↗
PubMed1980

[Signs of hypercoagulability in hyperlipemic hypertensives].

The correlation between elevated serum lipids, shortened coagulation time, and the accelerated thrombosis measured in vivo was found in experimental animals. Elevated levels of some coagulation factors were found in samples of human hyperlipoproteinemic plasma. Experimental hypertension induced significant rise of serum cholesterol and some coagulation factors also. If thrombosis is important in the genesis of atheroclerosis, these findings could indicate that elevation of plasma lipids may play a role, via the coagulation pathway, in the production of human vascular disease. These findings encouraged us to test the group of patients with rised blood pressure and to correlate their lipid and coagulation status. Statistically significant difference between hyperlipemia and normolipemic hypertonics was seen in level of factors V and VII reduced fibrinolytic activity, decreased antithrombin III, and in higher rate of hypercoagulabilic thromboelastograms.

Blood Coagulation↗
PubMed1979

[Factor XII deficiency - Hageman trait. Additional diagnostic procedures].

In the previous paper published in the Bulletin for Hematology and Blood Transfusion we described the congenital deficit of Hageman factor (HF) with the basic findings. Now we provide addilioval laboratory -diagnostical tests in order to confirm definitively that our patients have the deficit of Factor XII, and not of some other factors of the contact coagulation phase as: Fletcher, Fitzgerald, Williams and Flaujeac. On the other hand, in order to enlight the laboratory-diagnostical problems which one can face in solving of these cases, we have reviewed the basic biochemical characteristics of the contact factors and the mechanism of the beginning of the internal pathway of blood coagulation.

Factor IX↗
PubMed1979

[Factor VII deficit-hypoconvertinemia].

Congenital deficit of Factor VII is a rare deficit perceived within women and men. Clinicaly it is manifested with mild hemoragical diatesa and of laboratory tests: prolonged on stage prothrombin time, reduced activity of Factor VII and normal APTT. In this article we describe the family in which we have found two cases of congenital deficit of Factor VII, biochemical characteristics, differential laboratory diagnosis and correction of deficit in the case of bleeding.

Adult↗
PubMed1978

[Factor XII deficiency - Hageman trait. Report of 2 cases].

For the first time in our literature we have described the two cases of hereditary deficiency of factor XII (Hageman trait), a very rare disorder. It was discovered when a long clotting time was found in our patients during the course of a preoperative evaluation. Abnormal thrombelastogram, with a picture typical for hemophilia, gave as a reason to continue with laboratory investigation. The laboratory findings showed us a very low value of factor XII in one case, and total absence of factor XII in the other.

Adult↗