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Biomedical subjects

P Martinetto

Publications and source records attributed to P Martinetto.

At least 37 records · Page 2Linked to original sources
PubMed1979

[Antibiotic resistance transmissible in "minor" Salmonella strains recently isolated in the Piedmont region].

The presence of R factors in one hundred (100 strains of Salmonella, recently isolated in Piedmont Region, has been investigated. The resistance to 9 antibiotics has been determined for these strains. 83 proved resistant to one or more antibiotics and in particular 57 of these proved to be multiresistant. Only 18 R factors were put in evidence, 13 of these belonging to Salmonella wien. The majority of the R factors found were present in strains of Salmonella isolated from healthy carriers.

Ampicillin↗
PubMed1979

[Influence of composition of the culture media on the in vitro determination of the bacterial sensitivity to sulfonamides, trimethoprim and cotrimoxazole].

The difficulties concerning the interpretation of results of susceptibility tests to sulphonamides, trimethoprim, co-trimoxazole have been investigated. The zones of inhibition produced by discs containing these drugs are peculiar since frequently they contain a light bacterial growth and small colonies. Therefore the real sensitivity or resistance of the microorganism is questionable. Susceptibility tests performed on media of different composition, have shown that the phenomenon is chiefly due to the presence in the medium of thymidine and methionine. Both the substances are end-products of the metabolic pathway on which act sulphonamides, trimethoprim, co-trimoxazole. When they are in the medium, they can be available for the bacteria in spite of the inhibition caused by the mentioned drugs.

Bacteria↗
PubMedDate not supplied

Variability of immune response induced by bacteria treated with subminimal inhibitory concentrations of fosfomycin.

Experiments were conducted to explore the possibility that bacterial strains treated with subminimal inhibitory concentrations (sub-MICs) of fosfomycin might induce immune responses different from those induced by intact, untreated bacteria. A preliminary study was done with a strain of Salmonella wien. The immune response in rabbits immunized with bacteria that had been exposed to either the sub-MIC or the minimal inhibitory concentration (MIC) of fosfomycin was compared with that in rabbits immunized with S. wien not exposed to the drug. The titers of antibody to S. wien in rabbits immunized with abnormal, sub-MIC-treated bacteria were higher than those in rabbits immunized with either MIC-treated or untreated S. wien. This difference was seen not only with the total antigen of Salmonella but also with somatic (O) and flagellar (H) antigens.

Agglutination Tests↗