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Biomedical subjects

P Martin

Publications and source records attributed to P Martin.

At least 721 records · Page 40Linked to original sources
PubMed1989

[Outcome of the kidney with vesico-ureteral reflux. Apropos of 129 cases].

The final status of the kidneys of 129 children suffering from vesico-ureteric reflux was studied. The growth of the kidneys was comparable in the surgically treated and in the medically treated group. However, growth was better when the kidneys had been normal initially than when they presented renal scars. New scars were more frequent in the medically treated group, and/or when scars were already present at diagnosis of vesico-ureteric reflux. Our results are in agreement with those in the literature.

Adolescent↗
PubMed1989

Engraftment in 86 with patients lymphoid malignancy after autologous marrow transplantation.

The kinetics of marrow engraftment was retrospectively analysed in 55 patients with malignant lymphoma (ML) and 31 patients with acute lymphoblastic leukemia (ALL) after marrow-ablative therapy followed by autologous bone marrow transplantation. Thirty-eight percent of patients with ML, most of whom were transplanted in relapse and 13% of patients with ALL, mostly transplanted in remission, showed failed or delayed engraftment. Analysis of the total patient group showed that failure to recover platelet counts was significantly correlated with detection of disease in the marrow early after transplantation (p less than 0.001). Platelet recovery was also correlated with survival (p = 0.0001), disease-free survival (p = 0.0001), and the probability of relapse (p = 0.02). In those patients achieving engraftment, multivariate regression analysis failed to reveal any single in vitro test of marrow nucleated cell or progenitor cell numbers that significantly influenced time to achieve recovery of either granulocyte or platelet counts.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1989

[Modification of aerobic digestive flora in patients in intensive care during and after treatment with cefmenoxime].

To evaluate the resistant strains selection during treatment with cefmenoxime, a 3rd generation cephalosporin, 10 adult inpatients of an intensive-care unit had quantitative stool cultures, before the treatment, on the 7-10th day of therapy, and 7-10 days after the end of the antibiotic course. The results show that the selecting effect of cefmenoxime is not different from the effect previously observed for cefotaxime.

Candida albicans↗
PubMed1989

Primary lymphoma of the liver in a patient with acquired immune deficiency syndrome and chronic hepatitis B.

We describe the case of a homosexual man with asymptomatic infection with human immunodeficiency virus and hepatitis B virus who developed primary hepatic lymphoma. The lymphoma presented with rapid enlargement of the liver, and ultrasound examination revealed multiple hypoechoic lesions within the liver. Histological examination of the liver showed massive replacement by lymphomatous tissue, as well as changes of chronic active hepatitis B. Immunohistochemical stains for hepatitis B surface and core antigens were strongly positive in almost all hepatocytes, but not in tumor tissue. Whereas the occurrence of lymphoma probably is related to HIV infection, possible interactions between hepatitis B virus and HIV infection are discussed. Thus, the presence of mass lesions within the liver in a patient with HIV infection should raise the possibility of hepatic lymphoma even if there is no evidence of generalized lymphadenopathy.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Origins of the neurovascular bundle: interactions between developing nerves and blood vessels in embryonic chick skin.

Growth cones of nerves and endothelial cells of blood vessels are closely analogous in their migratory behavior, and they are both set a similar task during the early development of a limb. Both must invade the mesenchyme to form ramifying networks of large nerves and vessels. Both systems must densely pervade certain regions of the developing limb, such as muscle rudiments, and both form dense cutaneous plexuses at precisely the same depth beneath the epidermis. Moreover, adult tissues show many examples of neurovascular bundles in which nerves and blood vessels run closely parallel and branch in a correlated fashion, suggesting some interdependence during development. We have examined the interrelationship between developing nerves and blood vessels in chick wing skin because it allows a particularly convenient two-dimensional analysis of the two systems which can be revealed simultaneously in the same preparation by injection of Indian ink combined with silver-staining. We show that nerves do not use blood vessels as pathways along which to crawl, but that there are two other ways in which neurovascular associations arise: in some situations nerves and blood vessels follow the same route because they are responding independently to the same mesenchymal cues; and in some situations nerves induce blood vessels to remodel around them.

Animals↗
PubMed1989

The effectiveness of a cardiopulmonary resuscitation program for mothers of newborn infants.

To investigate the effectiveness of a 15-minute videotape on how to perform cardiopulmonary resuscitation (CPR) on a newborn infant, 28 mothers of normal term babies completed a 12-item test on infant CPR before, immediately after, and 4-6 weeks after viewing the videotape. Statistical analysis showed that the videotape significantly improved scores on the first post-test as compared with the pre-test. At final testing, scores were significantly lower than at the first post-test, but still significantly higher than the pre-test scores. CPR education should be adopted by all institutions providing obstetrical care.

Female↗
PubMed1989

[Diffuse gangrenous cervicofacial cellulitis of stomatologic origin in 7 patients with HIV-1 infection].

A new clinical aspect of AIDS in Africa is represented by acute gangrenous cervico-facial cellulitis. In most of cases, the infection was due to infected tooth. Seven patients presenting with such clinical findings were HIV-1 infected (Western Blot). Bacteriological investigations failed to show bacteria responsible of these syndromes except for 4 cases. All patients healed after surgical treatment done in emergency and antibiotherapy. No mediastinal localisation was noticed. Prevention by removing all infected teeth must be emphasized in HIV infected patient.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[The behavior of cytoplasmic progesterone receptors in the cycling endometrium and the effect of hormonal contraceptives].

Concentration of cytosolic progesterone receptor (PR) was measured by means of an exchange procedure in the endometria of 80 women. Investigations carried out in 35 normal menstruating females showed a gradual increase of PR during the preovulatory and immediate postovulatory phases, decreasing to the lowest level at the end of the cycle. Measurements in endometrial samples obtained from women on combined hormonal contraceptives demonstrated a significant decline of PR concentration in the periovulatory phase resulting in a flattening of the sinusoid PR concentration curve. The stronger down regulation effect of the preparation containing 1.5 mg of dienogest is due to the higher progestogenic efficacy of dienogest in the respective dosage. We consider the down regulation phenomenon a useful means among others to characterize the progestogenic potency of a steroid.

Adult↗
PubMed1988

[Amyloidosis of the kidneys in Crohn disease].

At the instance of the variegated anamnesis of a patient with Crohn's disease the unusually rapid development of a secondary amyloidosis of the kidneys is described. Crohn's disease became manifest at the 17th year of age. The severe course of the disease of the last four years with relapsing intraabdominal abscesses and multiple formations of fistulae might be significant for the pathogenesis of the amyloidosis. If the local complications of Crohn's disease are controlled then the amyloidosis still threatens the patient's life. In case the inflammatory process could be cured the consequence would as expected be the alleviation of the amyloidosis. An additional colchicine therapy may then accelerate the process of healing. However, the nature of Crohn's disease is uncertain.

Adult↗
PubMed1988

Triiodothyroacetic acid (TRIAC) potentiation of antidepressant-induced reversal of learned helplessness in rats.

The results of several clinical investigations have suggested that a special relationship exists between thyroid function and affective disorders and/or the therapeutic response to antidepressants. Animal studies have shown the possible beta-adrenergically mediated antidepressant-like properties of triiodothyroacetic acid (TRIAC) in rodents. The present experiment showed (1) that the reversal by antidepressants (clomipramine or imipramine) of escape deficits produced by previous exposure to uncontrollable shock was significantly hastened in animals given TRIAC and (2) that L-penbutolol treatment prevented the elimination of helpless behavior induced by TRIAC, suggesting a beta-adrenergic mediation of the antidepressant activity of thyroid compounds. The study confirmed that learned helplessness might be a useful model for studying in animals the neurohormonal correlates of affective disorders and the neurobiochemical basis of the enhancement of the antidepressant action produced by thyroid compounds.

Animals↗
PubMed1988

Reversal of helpless behavior in rats by putative 5-HT1A agonists.

This study is designed to measure effects of serotonin 1A (5-HT1A) agonists on escape deficits produced by inescapable shock in rats--a model of learned helplessness. Rats were first exposed to 60 inescapable shocks (15-sec duration, 0.8 mA, every 1 min +/- 15 sec), and 48 hr later, they were subjected to daily 15-min shuttle-box sessions (30 trials/day) on 3 consecutive days. Twice daily intraperitoneal injection of buspirone (total daily dose of 0.5 and 1 mg/kg), gepirone (0.06 and 0.125 mg/kg), 8-OH dipropylamino-tetralin (8-OH-DPAT) (0.03, 0.06, 0.125, and 0.25 mg/kg), and ipsapirone (TVXQ 7821) (0.03 and 0.06 mg/kg) eliminated escape failures. This indicates that an antidepressant-like effect--reversal of helpless behavior--can be obtained with drugs assumed to stimulate serotonin 1A receptors.

8-Hydroxy-2-(di-n-propylamino)tetralin↗