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Biomedical subjects

P Mandel

Publications and source records attributed to P Mandel.

At least 235 records · Page 13Linked to original sources
PubMed1981

[Effect of sodium dipropylacetate on experimental convulsions produced by pentetrazole and picrotoxin].

Sodium dipropylacetate, an anticonvulsant used in human therapy, gives a more efficient protection against convulsions elicited by pentetrazol than by picrotoxin. In the case of picrotoxin induced convulsive seizures where there is an alteration at the GABA receptor level, ther is a lack of efficiency after nDPA treatment which increases GABA at the synaptic level. DPA is more effective against pentetrazol convulsive seizures where no direct participation of GABAergic receptors seems to occur. The efficiency of potentialisation of GABAergic mediation is a function of the mechanism by which the seizure is triggered.

Animals↗
PubMed1981

[Mechanism of action of an anticonvulsant, sodium dipropylacetate].

The hypothesis that the brain GABA level increase which is induced by a sodium dipropyl acetate treatment arises either through inhibition of succinic semialdehyde dehydrogenase (SSADH), or through inhibition of GABA transaminase by succinic semialdehyde (SSA), has been considered. It appeared that in vivo brain GABA level increase cannot be attributed to SSADH inhibition, and that SSA is not a GABA precursor. It has been shown that SSA is neither in vivo nor in vitro a GABA-transaminase inhibitor. 4-hydroxybenzaldehyde, a potent SSADH inhibitor did not increase GABA level at a dosage which induces a 99% inhibition of SSADH.

4-Aminobutyrate Transaminase↗
PubMed1980

[Free nucleotides of nerve cells, in culture].

In primary cultures the free nucleotide (FN) distribution pattern showed a slight increase of adenylic nucleotides in neuroblasts as compared to glioblasts. Significant differences in the FN distribution were found between primary cultures and clonal nerve cell lines.

Animals↗