Biomedical subjects

P Maincent

Publications and source records attributed to P Maincent.

56 records · Page 4Linked to original sources

PubMedDate not supplied

Modification of in vivo Ca(2+)-uptake by parenterally administered aluminum complexes.

The parental administration of complexed aluminum induces a very significant increase of Ca(2+0-uptake by various tissues. The effects are more important with aluminum-ATP complex than with the simultaneous administration of aluminum lactate and sodium ATP. In the last case the increase in calcium uptake does not reach the many fold (up to 7 times) values observed with aluminum-ATP complex. In this aluminum-induced modification of cellular calcium homeostasis ATP appears to act as a mediator of the metal complex effects. These experimental results emphasize the importance of the role of ATP in the biological properties of low molecular weight metal complexes.

Adenosine Triphosphate↗

PubMedDate not supplied

Long-term oral administration of aluminum in mice. Aluminum distribution in tissues and effects on calcium metabolism.

Six months of oral administration of aluminum lactate provokes an important accumulation of aluminum in various tissues of mice. The accumulation magnitude order is spleen > kidney > brain > liver > blood. No systemic toxic effects (weight loss or neurolytic effects) were observed. Values of calcium content and 45Ca-uptake by the different tissues showed no modifications of calcium metabolism. The lack of calcium homeostasis modification caused by a probable aluminum insolubilization, and the incidence of other individual factors on individual deviations from group behavior is discussed.

Aluminum↗