Search PubMed⌕ Search

Biomedical subjects

P Magnusson

Publications and source records attributed to P Magnusson.

At least 55 records · Page 3Linked to original sources
PubMed1985

Idiopathic coronary artery dissection: a rare in vivo diagnosis.

A 42-year-old white female, who had an acute myocardial infarction, developed postinfarction angina and underwent coronary angiography seven weeks after the event. Coronary angiogram demonstrated a primary dissection of the left anterior descending artery. To our knowledge this is the sixth such report of a patient with primary dissection of a coronary artery demonstrated by angiography and the fourth such patient reported to achieve and maintain asymptomatic status without operative intervention.

Adult↗
PubMed1980

Aspects on the lateral fistulae and cysts of the neck.

The usual opinion in the literature is that lateral neck fistulae originate from branchial arch remnants. According to current theories, lateral cervical cysts may either develop from the branchial apparatus or have other etiology. To examine this an investigation was carried out among the relatives of patients with complete fistulae, and 36 per cent fistulae were found among the kin. For lateral neck cysts it was not possible to detect any similar tendency. Histological review of the operation specimens showed that in half of the cases there was seromucus glandular tissue surrounding the fistulae but with regard to the cysts no such tissue was found. This supports the opinion that fistulae and cysts may have a different genesis.

Branchial Region↗
PubMed1979

Lateral fistulae and cysts of the neck. Heredity and diagnosis.

A family with congenital fistulae from the second cleft or pouch over four generations is described. In order to obtain some idea of how often anomalies are found in relatives of patients with this type of malformation a material embracing 114 patients has been examined. The investigation demonstrates that patients with a complete lateral fistula of the neck from the second cleft or pouch showed a heredity of 35%, whilst patients with lateral neck cysts did not show any recognizable familial tendency. Views on differential diagnosis are presented, including the value of fine-needle biopsy, where in 92% of the cases a diagnosis of branchial cysts of the neck was obtained.

Biopsy, Needle↗
PubMed1977

Selective cannulation of the anterior interventricular vein and coronary sinus: potential applications.

A technique of cannulation of the anterior interventricular vein (AIV) selectively, along with selective cannulation of the coronary sinus, is described. The technique was successful in 61 of 82 patients (76%) in whom it was attempted. There were no serious complications. The technique allows one to obtain blood samples simultaneously from the anterior interventricular vein and the coronary sinus, so that the metabolism of the left ventricular anterior wall and that of the overall left ventricle can be studied. Possible clinical applications of simultaneous investigation of the left ventricular anterior wall and global myocardial metabolism are discussed.

Cardiac Catheterization↗
PubMed1976

Hemodynamic effects of nitroglycerin ointment in congestive heart failure.

The hemodynamic effects of nitroglycerin absorbed transcutaneously from an ointment base were determined in 10 patients with chronic congestive heart failure (9 with ischemic heart disease and 1 with cardiomyopathy). The response was characterized by a decrease in pulmonary capillary wedge pressure from an average of 30 to 19 mm Hg, and an increase in cardiac index from 1.7 to 2.2 liter/min per m2, with concomitant decreases in systemic and pulmonary vascular resistance and an increase in venous capacitance. Mean arterial pressure decreased from 85 to 80 mm Hg, and heart rate remained unchanged. The hemodynamic effects persisted for 3 to 6 hours. These results indicate that nitroglycerin ointment is a hemodynamically potent vasodilating agent with potential value in the therapy of congestive heart failure.

Aged↗
PubMed1976

Effects of vasodilator therapy for severe pump failure in acute myocardial infarction on short-term and late prognosis.

Forty-three patients with severe pump failure complicating acute myocardial infarction were treated with vasodilators (nitroprusside (40) and phentolamine (3)) for four hours to 27 days. Cardiac index, stroke volume index, and stroke work index (SWI) increased while the left ventricular filling pressure (LVFP) decreased during vasodilator therapy. Twenty-four of the 43 patients (56%) survived. Of patients with initial SWI between 11-20 gm-m/m2 and LVFP less than 15 mm Hg, 68% survived. In contrast only 18% of patients with SWI of 10 gm-m/m2 or less and LVFP greater than 15 mm Hg survived. Of the 17 patients with clinical shock, 8 (47%) survived. All 24 patients discharged from the hospital were followed for at least 12 months. Fourteen patients died one to 25 months (average 9.2 months) after discharge and the cause of death was pump failure in ten of them (71%). The ten survivors at last follow-up had been followed for 15 to 32 months (average 24 months). The cumulative survival at 24 months was 28%. Thus, despite improvement in short-term prognosis with vasodilator therapy in patients with severe pump failure complicating acute myocardial infarction, the prognosis for long term survival remains unfavorable, possibly due to severe intrinsic cardiac damage.

Acute Disease↗
PubMed1975

Abnormal regional metabolism and mechanical function in patients with ischemic heart diseases: improvement after successful regional revascularization by aortocoronary bypass.

Left ventricular anterior wall metabolism was investigated concurrently with global myocardail metabolism by simultaneous preoperation sampling of anterior interventricular venous (AIV) and coronary sinus (CS) as well as arterial bloods in seven patients with severe obstructive lesions of the major coronary arteries, including left anterior descending. Postoperative study was performed two weeks to six months following successful aortocoronary artery bypass surgery. All grafts including the aorto-left anterior descending artery grafts were patent. Preoperatively in three of the seven patients, anterior wall lactate extraction (R%L) was negative at rest. The average R%L at rest (7 +/- 14%) was abnormal and was negative (-49 +/- 26%) at a maximum supraventricular pacing rate (MPR) of 137 +/- 4.6 beats/min. Postoperatively, not only was resting R%L (39 +/- 4;4%) normal but also it remained normal during atrial pacing (32 +/- 8.5%) even though the postoperative MPR (164 +/- 4.4 beats/min) was much higher than the preoperative MPR; Postoperatively AIV pO2 both at rest (21 +/- 1.1 mm Hg) and at MPR (22 +/- 1.3 mm Hg) and directly determined O2 saturations (resting: 34 +/- 3.0%; MPR:35 +/- 2.1%) tended to be higher than the preoperative values (AIV pO2, resting: 18 +/- 1.7; MPR: 19 +/- 1.7 mm Hg; AIV O2 saturation resting: 30 +/- 2.7; MPR: 33 +/- 3.3%), although only differences in pO2 were statistically significant. In five of the seven patients in whom the pre and postoperative left ventricular angiograms could be compared, systolic wall motion of the left ventricular anterior wall improved markedly postoperatively. Average global myocardial lactate extraction (G%L) preoperatively was normal (19 +/- 4.8%) at rest but was negative (-22 +/- 12%) at MPR. Postoperatively however, G%L both at rest (44 +/- 5.5%) and at MPR (34 +/- 7.9%) were normal. Coronary sinus pO2 and O2 saturation were also higher postoperatively compared to the preoperative values. Over-all left ventricular performance indicated by increase in ejection fraction also improved postoperatively. This improvement was not caused by increased coronary blood flow. Postoperative coronary sinus blood flow both at rest (114 +/- 19 ml/min) and at MPR (199 +/- 27 ml/min) however were less than the preoperative values (resting 136 +/- 24, MPR 261 +/- 40 ml/min), There was also no increase in global O2 delivery and O2 consumption despite higher heart rate and rate-pressure product achieved during postoperative pacing stress and the patients did not develop angina. These findings suggest that improved regional and global metabolism and mechanical functions observed postoperatively in these patients may be due to redistribution of blood flow to the ischemic and nonischemic myocardium following successful aortocoronary artery bypass surgery.

Adult↗
PubMed1975

Improved angina threshold and coronary reserve following direct myocardial revascularization.

Angina threshold, coronary reserve, and global myocardial lactate metabolism were studied by atrial pacing in 18 patients with obstructive coronary artery disease before and after aortocoronary artery bypass (ACB) surgery. In 3 of these 18 patients, regional (anterior wall) metabolism was also studied. Following ACB, 16 of the 18 patients did not develop angina at the maximum pacing rate (MPR). One patient developed angina postoperatively at a similar rate as before surgery. In the other patient, postoperative angina threshold was much higher. In the group as a whole, postoperative MPR (159 +/- 3.5 beats/min) was much higher than the preoperative angina rate (124.9 +/- 4.9 beats/min; P less than 0.001). Rate-pressure product (RP) at MPR postoperatively (21.5 +/- 0.89 mm Hg/min X 10(-3)) was also higher than RP at angina rate preoperatively (18.8 +/- 0.92 mm Hg/min X 10(-3); P less than 0.01). Although coronary sinus blood flow (CSBF) both at rest (152 +/- 16.2 ml/min) and at MRP (266 +/- 27.5 ml/min) postoperatively was higher than preoperative CSBF at rest (111 +/- 10.7 ml/min; P less than 0.05) and at angina rate (202 +/- 19.9 ml/min; P less than 0.05), arterial-coronary sinus O2 content (Art.-CSO2) difference was significantly lower postoperatively both at rest (8.9 +/- 0.37 ml/min) and at MPR (9.1 +/- 0.44 ml/min) compared with the preoperative Art.-CSO2 at the rest (12.7 +/- 0.40 ml/min; P less than 0.01) and at angina rate (12.4 +/- 3.8 ml/min; P less than 0.01)...

Adult↗