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Biomedical subjects

P Magnenat

Publications and source records attributed to P Magnenat.

At least 37 records · Page 2Linked to original sources
PubMed1978

The displacement of albumin bound bilirubin by free fatty acids in vivo.

Variations in bilirubinaemia in response to alterations of the free fatty acid level was studied in conscious and unstressed Gunn rats. When only one molecule of bilirubin is bound to albumin (without bilirubin overload), no displacement of bilirubin is observed, even if the protein binds as much as 6 molecules of free fatty acids. After overloading with exogenous unconjugated bilirubin, the second site of fixation of bilirubin on albumin is partly occupied; in this situation, a displacement is observed, but only when more than 3.5 molecules of free fatty acids are simultaneously bound to the protein. In vivo, free fatty acids do not spontaneously reach such levels as those responsable for the observed displacement of bilirubin. In the ranges of bilirubin and free fatty acids concentrations likely to be encountered clinically, free fatty acids might not represent an effective agent of displacement for bilirubin, as it is commonly thought.

Animals↗
PubMed1976

[The effect of flavonoid compounds (+)-cyanidanol-3 in acute viral hepatitis].

A double blind study was carried out with 14 pairs of patients suffering from acute virus hepatitis in order to determine the action of (+)-cyanidol-3 (2 g daily, administered orally). Among these few patients no significant differences were observed between the two groups. This also holds true for the liver function test with the exception of total serum bilirubin. In the treated patients hyperbilirubinemia decreased significantly faster than in the untreated group (p smaller than 0.05). The values registered with a daily dosis of 1 g (+)-cyanidol-3 did not differ from those recorded in the groups of untreated patients.

Alanine Transaminase↗
PubMed1975

[Treatment of ascites by ultrafiltration and reinjection of the proteins].

Report on 14 cases of ascites resistant to conservative treatment such as saltless diet, diuretics including spironolactone, and bedrest. 12 cases were due to alcoholic cirrhosis and a further 2 had malignant tumors (1 hepatoma, 1 adenocarcinoma of the pancreas). 14 patients underwent dialysis in which, after puncture of the ascites, the proteins are concentrated by filtration and then reinjected into the circulation. 16 dialyses were performed and all were well tolerated except in one alcoholic woman in very poor general condition who died from acute pulmonary edema. No significant clinical complications or technical problems were encountered. The dialysis-reinjection time lasted 3-28 h and the bodyweights diminished by 2.4-17 kg. Plasma volume, renal output and urinary concentration of electrolytes (Na) increased during dialysis. In 6 cases these effects persisted with spironolactone and low salt diet only, probably because of better renal perfusion and re-established sensitivity to the diuretic treatment. One year follow up revealed 4 cases out of 13 without relapse. Rapid emptying of the peritoneal cavity permitted two laparoscopies, which revealed the tumoral origin of the ascites in two cases, and one laparotomy for porto-caval shunt in bleeding esophageal varices at the earliest possible juncture. This method of treating cirrhotic ascites is simple and well tolerated. It considerably shortens the hospitalization and may rapidly improve general conditions of life in these chronic patients.

Alcoholism↗