Biomedical subjects

P M Satchell

Publications and source records attributed to P M Satchell.

23 records · Page 2Linked to original sources

PubMed1984

Abnormalities of oesophageal mechanoreceptors in canine acrylamide neuropathy.

Dogs exposed to acrylamide develop peripheral neuropathy and megaoesophagus. The properties of slowly adapting oesophageal mechanoreceptors were studied in six control and five acrylamide affected greyhounds in which the oesophagus had been surgically isolated under anaesthesia and oesophageal pressure was controlled while monitoring impulses in oesophageal afferent fibres in the cervical vagus. In the acrylamide affected animals oesophageal afferent units had elevated thresholds and significantly reduced firing rates during ramp increases in oesophageal pressure. It is concluded that abnormalities of oesophageal mechanoreceptors may be important in the pathogenesis of certain oesophageal motility disorders in man and animals.

Acrylamide↗

PubMed1982

Abnormalities in the vagus nerve in canine acrylamide neuropathy.

Dogs exposed to acrylamide develop a sensorimotor peripheral neuropathy and megaoesophagus. The presence of neuropathy was confirmed electrophysiologically and histologically. Hindlimb motor conduction velocity was reduced and there was a loss of large diameter myelinated fibres in the dorsal common digital nerve and the tibial nerve. The conduction velocity of vagal motor fibres innervating the thoracic oesophagus was not decreased; there was a reduction in the conduction velocity of the mixed nerve action potential of the vagus. Degenerating nerve fibres were observed in the vagus in the midthoracic region. The damage to vagal nerve fibres may be an important factor in the causation of megaoesophagus.

Acrylamides↗

PubMed1982

The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats.

This study examined the effects of an aldose reductase inhibitor (CP 45634, Sorbinil, Pfizer, New York, New York) on the neuropathy of streptozotocin-induced diabetic rats. Sorbinil treatment for 4 wk reduced sciatic nerve sorbitol concentration and improved motor nerve conduction velocity in diabetes of 2-9 mo duration. It remains to be determined whether Sorbinil can prevent chronic diabetic neuropathy.

Aldehyde Reductase↗

PubMed1981

Megaoesophagus due to acrylamide neuropathy.

Greyhound dogs exposed to oral acrylamide for a period of eight weeks developed a sensorimotor peripheral neuropathy that had many features in common with acrylamide neuropathy seen in other species. Most of the animals also developed the clinical and radiological features of megaoesophagus. The association of neuropathy and megaoesophagus suggests that an axonopathy of the vagus may be an aetiological factor in this disorder.

Acrylamide↗

PubMed1977

Familial hypokalaemic periodic paralysis in papua nuiginians--a reappraisal.

Studies of 11 Papua Nuiginians with recurrent muscular paralysis are presented. The clinical pattern, the geographical clustering, the lack of relation with dietary change, and the normal aldosterone levels in two patients support the view that it is a variant of familial hypokalaemic periodic paralysis.

Adolescent↗