He often begins to answer before you have finished asking your question, but his replies are to the point. He speaks with emotion about the people he hopes to help, particularly children with fatal genetic diseases. 'I prefer to do something: the outcome of doing nothing is perfectly clear', he says. He began sequencing human genes while others were discussing how and when to do so. His methods have been called inelegant, redundant, wasteful, and too 'industrial'. Will his method fail to detect some infrequently transcribed genes? That's all right with him. He is not concerned with finding all the human genes, but rather with the fastest possible route to a useful catalog of most human genes.

Chromosome Mapping↗

PubMed1995

How do antidepressants work?

Explore the source record for details and available documents.

8-Hydroxy-2-(di-n-propylamino)tetralin↗

PubMed1995

Neural networks: a bridge between neuroscience and psychology.

Between the anatomy and physiology of neurons on the one hand, and the study of perception and personality on the other, there is a vast gap in our understanding. Although, today, most neuroscientists say it is axiomatic that the phenomena of mind result from the operation of the brain, they could not tell you how.

Aphasia↗

PubMed1995

Galanin and the galanin antagonist M40 do not change fat intake in a fat-chow choice paradigm in rats.

The neuropeptide galanin has been proposed to play a role in the regulation of fat intake. The purpose of the present investigation was to determine if galanin and the galanin receptor antagonist M40 would have selective effects on fat intake in a fat-chow choice paradigm in rats. Rats were adapted to 22-h access to chow alone and 2-h daily access to separate sources of fat and chow in the early dark cycle. Galanin (300 pmol, 1 nmol) or M40 (2-500 pmol) was microinjected bilaterally into the paraventricular nucleus of the hypothalamus (PVN) before the 2-h choice period, and chow and fat intake were measured. M40 had no effect on chow or fat intake. Galanin stimulated chow intake and increased the ratio of chow to fat consumed but had no significant effect on fat intake alone. These results suggest that endogenous galanin in the PVN may not play a primary role in the regulation of fat intake when fat is available in addition to a nutritionally balanced diet.

Analysis of Variance↗

PubMed1994