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Biomedical subjects

P M Perry

Publications and source records attributed to P M Perry.

At least 73 records · Page 4Linked to original sources
PubMed1983

Measured 234,238U and fallout 239,240Pu in human bone ash from Nepal and Australia: skeletal alpha dose.

Human bone samples from Nepal and Australia were analyzed for isotopic uranium and fallout plutonium. The Nepalese samples were obtained for a 3-yr period (1976-78) while the Australian samples are representative of a single year (1977). The surface air plutonium concentrations for the latitude bands of these countries were either measured and/or estimated from 1954 through 1978. With the plutonium air concentrations and age-dependent breathing rates as input data, the measured human bone results were compared with skeletal estimates derived from the ICRP Task Group Inhalation Model, and the agreement was found to be reasonably good. The measured isotopic uranium concentrations in these samples provide a benchmark against which to assess fallout plutonium based upon a comparison of the skeletal alpha radiation dose from a natural actinide to these populations.

Adolescent↗
PubMed1978

99Tcm-polyphosphate uptake by breast tumours.

Technetium polyphosphate uptake by breast tumours has been investigated in 69 patients. Although 70 per cent (38 out of 54) of malignant tumours took up the isotope in comparison with 45 per cent (5 out of 11) of benign lesions, this technique would be unreliable for diagnostic purposes.

Breast Neoplasms↗
PubMed1978

Increasing incidence of ampicillin resistance in Hemophilus influenzae.

The incidence of ampicillin resistance in Hemophilus influenzae and its medical significance have not been extensively determined. During 1975-1977, we tested for ampicillin resistance 489 consecutive middle-ear isolates of HI obtained from children in Huntsville, Alabama, and 719 consecutive laboratory isolates of HI from Children's Hospital, Boston. The annual incidence of Amp resistance rose progressively in each survey, from initial values of 1.4 to 5.3% in 1975, to 14 to 16% in 1977 (P less than 0.05), a mean annual rate of increase approximately twofold. Resistance was equally prevalent among type b and non-b isolates and among nasally carried and disease-associated isolates (from blood, CSF, middle ears). Patients harboring AmpR isolates were much more likely to have had recent exposure to beta-lactam antibiotics (P less than 0.01).

Ampicillin↗
PubMed1975

Cerebral function before and after carotid endarterectomy.

Twenty men had their cerebral function measured preoperatively and three months after carotid endarterectomy using the Halstead-Reitan neuropsychological test battery. Thirteen patients were cerebrally impaired preoperatively, but 12 of them improved appreciably after surgery. Changes in internal carotid arterial blood flow measured preoperatively showed no significant correlation with the improvement in neuropsychological status. We think that carotid endarterectomy carries an even better prophylaxis for the brain as a whole than had been thought.

Carotid Arteries↗
PubMed1974

The control of bile acid pool size: effect of jejunal resection and phenobarbitone on bile acid metabolism in the rat.

In patients with cholesterol gallstones, there is a diminished bile acid pool and the bile becomes supersaturated with cholesterol. Medical treatment has been aimed at re-expanding the pool to improve cholesterol solubility in bile but as yet the factors controlling the size of the bile acid pool' are unknown. Therefore the role of the liver and intestine in controlling bile acid pool size in the rat was studied and the effect of experimental expansion of the pool on bile acid metabolism and bile lipid composition examined. Bile acid absorption was increased from ileum made hyperplastic by previous jejunectomy and hepatic bile acid synthesis was increased by phenobarbitone treatment. Both jejunal resection and phenobarbitone significantly increased the size of the bile acid pool from 32.2 +/- SEM 0.94 mumoles/100 g body weight to 42.2 +/- 1.71 and 44.4 +/- 2.03 respectively. However, the effects of these experimental manipulations on bile acid secretion rate, enterohepatic cycling frequency, and synthesis rates were quite different. Jejunectomy caused a 56% increase in bile acid secretion and more rapid cycling of the bile acid pool but the enhanced absorption did not depress bile acid synthesis. In contrast, phenobarbitone markedly increased synthesis from 14.5 +/- 1.42 mumoles.100 g BW(-1). 24 hr(-1) to 25.9 +/- 3.19 but there was no significant change in bile acid secretion and the choleresis seen after phenobarbitone was mainly due to an increase in the bile acid-independent fraction of bile flow. In these experimental studies in the rat, expansion of the bile acid pool did not significantly change bile lipid composition or cholesterol solubility in bile.

Animals↗
PubMed1967

The effects of alteration of CO2 and pH on intestinal blood flow in the cat.

1. The effect of alteration of arterial blood pH on intestinal blood flow in the cat has been determined under conditions of constant perfusion pressure.2. Arterial blood pH was altered over the range 7.12-7.70 by infusion of acid and alkali. When end-tidal CO(2) was held constant, there was no change in intestinal blood flow.3. When arterial blood pH was altered over the range 7.19-7.55 by the administration of CO(2) at constant respiratory volume and rate, flow increased with increasing CO(2).4. The intestinal vascular bed was less responsive to noradrenaline at pH 7.2 than at pH 7.6. The change in sensitivity was evident when end-tidal CO(2) was controlled and depended therefore on a change in hydrogenion concentration.5. The dilator effect of CO(2) did not depend upon alteration of sensitivity to noradrenaline since it was seen after adrenergic blockade.

Animals↗