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Biomedical subjects

P M Madsen

Publications and source records attributed to P M Madsen.

7 recordsLinked to original sources
PubMed1994

Peritoneal mesotheliomas in Danish women: review of histopathologic slides and history of abdominal surgery.

An unexpectedly large number of peritoneal mesotheliomas among women was reported to the Danish Cancer Registry during the years 1960 through 1985. In a case-control study, we tested whether this was due to diagnostic misclassification or to direct exposure of the peritoneal membranes to talc during abdominal surgery. Tissue specimens were available from 96 reported peritoneal mesotheliomas; 35 cases (37%) were regarded as verified mesotheliomas, and 33 (34%) as possible mesotheliomas. Information on any intraabdominal surgery was obtained from the hospital records of these 68 cases and for 206 controls with a cancer of the uterine corpus or pancreas. No association was seen between peritoneal mesotheliomas and abdominal surgery performed more than 25 years prior to cancer diagnosis (odds ratio, 0.83; 95% confidence interval, 0.35-1.94). CONCLUSION. Misclassification of other cancers was the reason for the observed excess of peritoneal mesotheliomas.

Abdomen↗
PubMed1986

Distal intramural spread of rectal carcinomas.

Forty-three consecutive specimens of resected rectal carcinomas, 16 abdominoperineal and 27 anterior resections, were examined for distal intramural spread. Thirty-four of the resections were considered curative and nine palliative. Eighteen carcinomas (42 percent) showed no distal spread, and 14 (33 percent) showed very limited distal spread (0-5 mm). In the remaining cases, 11 (25 percent) had distal spread of more than 5 mm and eight of more than 10 mm. The eight carcinomas with distal spread of greater than 10 mm were advanced Dukes' C tumors. Only three were considered curable. All potentially curable carcinomas would have been resected adequately with a distal margin of only 1.5 cm except one signet-ring carcinoma with extensive lymph node metastases located in the lower rectum.

Aged↗
PubMed1986

Cystosarcoma phyllodes. A review of 19 cases with emphasis on the occurrence of associated breast carcinoma.

The clinico-pathological aspects of 19 cases of cystosarcoma phyllodes (CP) were reviewed with special attention to the occurrence of associated breast carcinoma (BC). Twelve women had histologically benign, 4 had borderline and 3 malignant CP. Recurrent CP was diagnosed in 9 women within 1 to 15 years after initial treatment. Of the 19 women, 5 had associated in situ or invasive BC, 2 with the primary CP and 3 with its recurrences. In 1 case the BC was located within the confines of the CP, whereas in 4 women the CP and BC were separate lesions. The frequency of incidentally found BC in this group of women with CP does not support the hypothesis of an increased risk of BC development in women with CP.

Breast↗
PubMed1985

[Acute proctitis].

Explore the source record for details and available documents.

Acute Disease↗
PubMed1985

Carcinoma recti. The predictive value of diagnostic biopsies for histologic grading.

The differentiation of 39 diagnostic biopsies, as determined by histologic grading, and that of the corresponding 39 rectal carcinomas were compared. About 60 percent of grade I tumors were diagnosed by grade I biopsies, while about 90 percent of grade II and only about 40 percent of grade III tumors were diagnosed by grade II and grade III biopsies, respectively. The results indicate caution when biopsy grading is used as a guidance to therapy, especially of poorly differentiated tumors.

Biopsy↗