Biomedical subjects

P M Jakob

Publications and source records attributed to P M Jakob.

At least 19 recordsLinked to original sources

PubMed2006

Scaling laws for transverse relaxation times.

Simple scaling laws are useful tools in understanding the effect of changing parameters in MRI experiments. In this paper the general scaling behavior of the transverse relaxation times is discussed. We consider the dephasing of spins diffusing around a field inhomogeneity inside a voxel. The strong collision approximation is used to describe the diffusion process. The obtained scaling laws are valid over the whole dynamic range from motional narrowing to static dephasing. The dependence of the relaxation times on the external magnetic field, diffusion coefficients of the surrounding medium, and the characteristic scale of the field inhomogeneity is analyzed. For illustration the generally valid scaling laws are applied to the special case of a capillary, usually used as a model of the myocardial BOLD effect.

Algorithms↗

PubMed2006

A simple geometrical description of the TrueFISP ideal transient and steady-state signal.

An intuitive approach is presented for assessment of the TrueFISP signal behavior in the transient phase and the steady state, based on geometrical considerations in combination with the Bloch equations. Short formulations are derived for the zenith and phase angle determining the direction of the magnetization vector for which a smooth monoexponential decay is obtained even at considerable off-resonance frequencies, thus compactly defining the target of various preparation schemes proposed in literature. A pictorial explanation is provided to illustrate how the interplay between RF excitation and relaxation governs the TrueFISP transient phase and steady state. Closed form expressions are developed that describe the signal evolution, accounting for the influence of T(1), T(2), flip angle, and resonance frequency offset in agreement with recently published studies. These results are obtained directly from basic assumptions, without the need for abstract mathematical treatment or further approximations. The validity of the conceptual framework and the analytical description is verified by simulations based on the Bloch equations as well as with MR phantom experiments. The theory may be used for contrast calculations and has the potential to facilitate improved parameter quantification with magnetization prepared TrueFISP experiments accounting for off-resonance effects.

Image Processing, Computer-Assisted↗

PubMed2006

[T1 maps and O2-enhanced MRT of the diseased lung. Emphysema, fibrosis, mucoviscidosis].

PURPOSE: Gas exchange is the primary function of the lung and the transport of oxygen plays a key role in pulmonary physiology and pathophysiology. MATERIALS AND METHODS: Molecular oxygen is weakly paramagnetic, so that an increase in oxygen concentration results in shortening T1 relaxation time and thus increasing signal intensity in T1 weighted images. The calculation of parameter maps may allow deeper insights into relaxation mechanisms. T1 maps based on a snapshot FLASH sequence obtained during the inhalation of various oxygen concentrations allow the creation of an oxygen transfer function, providing a measurement of local oxygen transfer. T1 weighted single shot TSE sequences demonstrate the signal changing effects during inhalation of pure oxygen. RESULTS: The average of the mean T1 values over the entire lung during inspiration was 1,199+/-117 ms, the average of these values during expiration was 1,333+/-167 ms. T1 maps of patients with emphysema and lung fibrosis show fundamentally different values and respiratory dependence compared to healthy individuals. Oxygen enhanced MR has the potential to assess reduced diffusion capacity and decreased transport of oxygen in patients with emphysema and cystic fibrosis. DISCUSSION: Results published in the literature indicate that T1 mapping and oxygen enhanced MR are promising new methods in functional imaging of the lung.

Administration, Inhalation↗

PubMed2005

Frequency distribution and signal formation around a vessel.

We describe the NMR signal formation properties of a single vessel. Instead of assuming the frequency distribution to be a simple Lorentzian or Gaussian one, we take into account that the frequency distribution around the vessel is a complex function. Considering the static dephasing regime we find a relationship between signal formation and frequency distribution. Analytical expressions for the frequency distribution in a voxel and the magnetization decay are obtained. In the case of small volume fractions of blood and week magnetic fields the results can be used for describing signal formation processes in a vascular network. A relationship between the frequency distribution and the properties of the vascular network is derived. The magnetization decay in different time regimes is discussed. The result is relevant for describing signal formation processes around a vessel for arbitrary pulse sequences.

Animals↗

PubMed2005

Transverse relaxation of cells labeled with magnetic nanoparticles.

We describe the NMR relaxation properties of magnetically labeled cells. The cells are labeled with magnetic nanoparticles (SPIO, USPIO), which generate susceptibility contrast. The geometry of the labeled cells and the surrounding tissue is considered. We assume that the magnetic nanoparticles accumulate to form a magnetic core of radius RC inside the cell. The correlation time tau, which describes the motion of spins around this core, is analyzed. Using the strong collision approach, explicit expressions are derived for the transverse relaxation rate R2* for tissue containing labeled cells as a function of the core radius, the diffusion coefficient, and the concentration of the nanoparticles. The predictions of this model agree well with numerical simulations and experimental data.

Cell Compartmentation↗

PubMed2004

23Na microscopy of the mouse heart in vivo using density-weighted chemical shift imaging.

The mouse has become an important animal model for human cardiac disease, and the development of techniques for non-invasive imaging of the mouse heart in vivo is, therefore, of great potential interest. Previous magnetic resonance imaging studies have concentrated on pathologically induced changes in cardiac structure and dynamics by acquiring proton images. Further information can be gained by studying cardiac function and physiology using other nuclei, for example, sodium. Sodium imaging of such a small structure presents considerable technical challenges. In this work we show the first sodium images of the mouse heart, with an isotropic spatial resolution of 1 x 1 x 1 mm, acquired in a time of 1.5 h. The ventricles, septum and myocardium are readily distinguishable in these images, which were acquired through the combination of 3D density-weighted chemical shift imaging, optimized instrumentation, and a high magnetic field strength (17.6 T). Measurements of the myocardial:blood sodium concentration in the left and right ventricles agree well with theoretical values.

Animals↗

PubMed2004

High-resolution MR imaging of the rat spinal cord in vivo in a wide-bore magnet at 17.6 Tesla.

The objective was to demonstrate the feasibility and to evaluate the performance of high-resolution in vivo magnetic resonance (MR) imaging of the rat spinal cord in a 17.6-T vertical wide-bore magnet. A probehead consisting of a surface coil that offers enlarged sample volume suitable for rats up to a weight of 220 g was designed. ECG triggered and respiratory-gated gradient echo experiments were performed on a Bruker Avance 750 wide-bore spectrometer for high-resolution imaging. With T*2 values between 5 and 20 ms, good image contrast could be obtained using short echo times, which also minimizes motion artifacts. Anatomy of healthy spinal cords and pathomorphological changes in traumatically injured rat spinal cord in vivo could be visualized with microscopic detail. It was demonstrated that imaging of the rat spinal cord in vivo using a vertical wide-bore high-magnetic-field system is feasible. The potential to obtain high-resolution images in short scan times renders high-field imaging a powerful diagnostic tool.

Animals↗

PubMed2004

Imaging lung function using rapid dynamic acquisition of T1-maps during oxygen enhancement.

This paper describes imaging of lung function with oxygen-enhanced MRI using dynamically acquired T1 parameter maps, which allows an accurate, quantitative assessment of time constants of T1-enhancement and therefore lung function. Eight healthy volunteers were examined on a 1.5-T whole-body scanner. Lung T1-maps based on an IR Snapshot FLASH technique (TE = 1.4 ms, TR = 3.5 ms, FA = 7 (composite function )) were dynamically acquired from each subject. Without waiting for full relaxation between subsequent acquisition of T1-maps, one T1-map was acquired every 6.7 s. For comparison, all subjects underwent a standard pulmonary function test (PFT). Oxygen wash-in and wash-out time course curves of T1 relaxation rate (R1)-enhancement were obtained and time constants of oxygen wash-in (w(in)) and wash-out (w(out)) were calculated. Averaged over the whole right lung, the mean w(out) was 43.90 +/- 10.47 s and the mean (w(in)) was 51.20 +/- 15.53 s, thus about 17% higher in magnitude. Wash-in time constants correlated strongly with forced expired volume in one second in percentage of the vital capacity (FEV1 % VC) and with maximum expiratory flow at 25% vital capacity (MEF25), whereas wash-out time constants showed only weak correlation. Using oxygen-enhanced rapid dynamic acquisition of T1-maps, time course curves of R1-enhancement can be obtained. With w(in) and w(out) two new parameters for assessing lung function are available. Therefore, the proposed method has the potential to provide regional information of pulmonary function in various lung diseases.

Administration, Inhalation↗

PubMed2004

[Feasibilities and limitations of high field parallel MRI].

In medical magnetic resonance imaging (MRI) it is standard to use MR scanners with a field strength of 1.5 Tesla. Recently, an ongoing development to higher field strength can be observed and a new clinical standard at 3.0 Tesla seems to be established. High field MRI with its intrinsic higher signal to noise ratio (SNR) can enable new applications of MRI in medical diagnosis, or can serve to improve existing methods. It is important to note, that the use of high field MRI is not without its limitations. Besides the SNR, other unwanted effects increase with a higher field strength. Without correction, these high field problems cause a serious loss in image quality. An elegant way to address these problems is the use of parallel imaging. In many clinical applications, parallel MRI (pMRI) is part of the standard protocol, because pMRI can enhance virtually every MRI application, without necessarily affecting the contrast behavior of the underlying imaging sequence. In high field MRI, besides the speed advantage of pMRI, the positive influence on high field specific problems and therefore on the image quality will be of major importance.

Artifacts↗

PubMed2003

Resolution enhancement in lung 1H imaging using parallel imaging methods.

Resolution in (1)H lung imaging is limited mainly by the acquisition time. Today, half-Fourier acquisition single-shot turbo spin-echo (HASTE) sequences, with short echo time (TE) and short interecho spacing (T(inter)) have found increased use in lung imaging. In this study, a HASTE sequence was used in combination with a partially parallel acquisition (PPA) strategy to increase the spatial resolution in single-shot (1)H lung imaging. To investigate the benefits of using a combination of single-shot sequences and PPA, five healthy volunteers were examined. Compared to conventional imaging methods, substantially increased resolution is obtained using the PPA approach. Representative in vivo (1)H lung images acquired with a HASTE sequence in combination with the generalized autocalibrating partially parallel acquisition (GRAPPA) method, up to an acceleration factor of three, are presented.

Humans↗

PubMed2002

Abdominal imaging with a modular combination of spin and gradient echoes.

MR-CAT (combined acquisition technique), a modular hybrid imaging concept, was introduced recently. In this article it is demonstrated that the CAT principles can be applied to form a versatile combination of spin and gradient echoes for abdominal imaging. This CAT approach, which essentially integrates RARE and EPI modules in a sequential fashion, was used to implement a set of segmented and single-shot RARE/EPI-CAT imaging techniques. CAT was used in in vivo studies to perform high-resolution abdominal imaging in five healthy subjects. The results demonstrate the feasibility of abdominal imaging using the proposed CAT approach and the potential of this technique to reduce imaging time while preserving image quality.

Abdomen↗

PubMed2001

Rapid quantitative lung (1)H T(1) mapping.

In this contribution, a rapid and robust technique for quantitative T(1) mapping of the human lung is presented. Based on a series of Snapshot FLASH tomograms acquired after a single inversion pulse, high quality and quantitative T(1) parameter maps acquired in under five seconds were obtained from six healthy volunteers. The measured T(1) values are in good agreement with previously reported literature values. T(1) maps were also acquired with the volunteers breathing room air or 100% O(2). The T(1) difference between breathing room air and 100% O(2) is statistically significant at P < 0.0001.

Adult↗

PubMed2001

VD-AUTO-SMASH imaging.

Recently a self-calibrating SMASH technique, AUTO-SMASH, was described. This technique is based on PPA with RF coil arrays using auto-calibration signals. In AUTO-SMASH, important coil sensitivity information required for successful SMASH reconstruction is obtained during the actual scan using the correlation between undersampled SMASH signal data and additionally sampled calibration signals with appropriate offsets in k-space. However, AUTO-SMASH is susceptible to noise in the acquired data and to imperfect spatial harmonic generation in the underlying coil array. In this work, a new modified type of internal sensitivity calibration, VD-AUTO-SMASH, is proposed. This method uses a VD k-space sampling approach and shows the ability to improve the image quality without significantly increasing the total scan time. This new k-space adapted calibration approach is based on a k-space-dependent density function. In this scheme, fully sampled low-spatial frequency data are acquired up to a given cutoff-spatial frequency. Above this frequency, only sparse SMASH-type sampling is performed. On top of the VD approach, advanced fitting routines, which allow an improved extraction of coil-weighting factors in the presence of noise, are proposed. It is shown in simulations and in vivo cardiac images that the VD approach significantly increases the potential and flexibility of rapid imaging with AUTO-SMASH.

Artifacts↗

PubMed2000

Hybrid cardiac imaging with MR-CAT scan: a feasibility study.

We demonstrate the feasibility of a new versatile hybrid imaging concept, the combined acquisition technique (CAT), for cardiac imaging. The cardiac CAT approach, which combines new methodology with existing technology, essentially integrates fast low-angle shot (FLASH) and echoplanar imaging (EPI) modules in a sequential fashion, whereby each acquisition module is employed with independently optimized imaging parameters. One important CAT sequence optimization feature is the ability to use different bandwidths for different acquisition modules. Twelve healthy subjects were imaged using three cardiac CAT acquisition strategies: a) CAT was used to reduce breath-hold duration times while maintaining constant spatial resolution; b) CAT was used to increase spatial resolution in a given breath-hold time; and c) single-heart beat CAT imaging was performed. The results obtained demonstrate the feasibility of cardiac imaging using the CAT approach and the potential of this technique to accelerate the imaging process with almost conserved image quality.

Coronary Vessels↗

PubMed2000

Partially parallel imaging with localized sensitivities (PILS).

In this study a novel partially parallel acquisition method is presented, which can be used to accelerate image acquisition using an RF coil array for spatial encoding. In this technique, Parallel Imaging with Localized Sensitivities (PILS), it is assumed that the individual coils in the array have localized sensitivity patterns, in that their sensitivity is restricted to a finite region of space. Within the PILS model, a detailed, highly accurate RF field map is not needed prior to reconstruction. In PILS, each coil in the array is fully characterized by only two parameters: the center of coil's sensitive region in the FOV and the width of the sensitive region around this center. In this study, it is demonstrated that the incorporation of these coil parameters into a localized Fourier transform allows reconstruction of full FOV images in each of the component coils from data sets acquired with a reduced number of phase encoding steps compared to conventional imaging techniques. After the introduction of the PILS technique, primary focus is given to issues related to the practical implementation of PILS, including coil parameter determination and the SNR and artifact power in the resulting images. Finally, in vivo PILS images are shown which demonstrate the utility of the technique.

Algorithms↗

PubMed2000

High-resolution diffusion imaging using a radial turbo-spin-echo sequence: implementation, eddy current compensation, and self-navigation.

This work describes a segmented radial turbo-spin-echo technique (DW-rTSE) for high-resolution multislice diffusion-weighted imaging and quantitative ADC mapping. Diffusion-weighted images with an in-plane resolution of 700 microm and almost free of bulk motion can be obtained in vivo without cardiac gating. However, eddy currents and pulsatile brain motion cause severe artifacts when strong diffusion weighting is applied. This work explains in detail the artifacts in projection reconstruction (PR) imaging arising from eddy currents and describes an effective eddy current compensation based on the adjustment of gradient timing. Application of the diffusion gradients in all three orthogonal directions is possible without degradation of the images due to eddy current artifacts, allowing studies of the diffusional anisotropy. Finally, a self-navigation approach is proposed to reduce residual nonrigid body motion artifacts. Five healthy volunteers were examined to show the feasibility of this method.

Anisotropy↗

PubMed2000

MR CAT scan: a modular approach for hybrid imaging.

In this study, a modular concept for NMR hybrid imaging is presented. This concept essentially integrates different imaging modules in a sequential fashion and is therefore called CAT (combined acquisition technique). CAT is not a single specific measurement sequence, but rather a sequence design concept whereby distinct acquisition techniques with varying imaging parameters are employed in rapid succession in order to cover k-space. The power of the CAT approach is that it provides a high flexibility toward the acquisition optimization with respect to the available imaging time and the desired image quality. Important CAT sequence optimization steps include the appropriate choice of the k-space coverage ratio and the application of mixed bandwidth technology. Details of both the CAT methodology and possible CAT acquisition strategies, such as FLASH/EPI-, RARE/EPI- and FLASH/BURST-CAT are provided. Examples from imaging experiments in phantoms and healthy volunteers including mixed bandwidth acquisitions are provided to demonstrate the feasibility of the proposed CAT concept.

Abdomen↗

PubMed2000

A multicoil array designed for cardiac SMASH imaging.

Recently, several partially parallel acquisition (PPA) techniques have been presented which use spatial information inherent in an RF coil array to reconstruct an image from a reduced set of phase encoding steps. PPAs represent a change in paradigm for the RF coil designer since the focus for arrays to be used with PPAs is to optimize the spatial encoding that is provided by the array. One of the first practical implementations of PPA imaging was demonstrated using the SMASH technique. In this study, we present our results from the construction of the first array designed specifically for cardiac SMASH imaging. Additional design criteria are presented for SMASH arrays that are not considered in conventional array design. Using these design criteria, a four-element array was constructed and then tested in SMASH imaging experiments in the heart. This array has been used in all of our initial cardiac and head SMASH studies with good results.

Biophysical Phenomena↗