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Biomedical subjects

P Luo

Publications and source records attributed to P Luo.

61 records · Page 4Linked to original sources
PubMed1992

[Nucleus fastigius-rostral ventrolateral medulla system is involved in vestibular depressor and bradycardia responses].

In urethane-anesthetized, tubocurarine-immobilized and artificially ventilated rats, microinjection of L-glutamate (Glu) into the nucleus fastigius or nucleus vestibular superior caused a depressor and bradycardia response. Both the depressor and bradycardia responses of the nucleus fastigius and nucleus vestibularis superior were blocked by preinjection of bicuculline (a GABAergic receptor blocker) into the rostral ventrolateral medulla. And the cardiovascular response-induced by excitation of the nucleus vestibularis superior could also be blocked by procaine-injection into the nucleus fastigius. These results indicate that the vestibular depressor and bradycardia response was induced via the nucleus fastigius rostral ventrolateral medulla system. Intravenous injection of methyl atropine also markedly attenuated the cardiovascular response of the nucleus fastigius, indicating that the vagus nerve is also involved in the depressor and bradycardia response of vestibulo-fastigial excitation.

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PubMedDate not supplied

Immunological characterization of peptide mimetics of carbohydrate antigens in vaccine design strategies.

Targeting antigens which cannot be readily addressed by genetic vectors is a major challenge in vaccine design. The inter-conversion of carbohydrate antigens into peptide mimetic forms provides a means to broaden the immune response to carbohydrate antigens. Peptides that mimic carbohydrate antigens offer new possibilities to augment immune responses to such antigens that include inducing carbohydrate reactive T-cell responses. Peptide mimeotopes can be formulated in a variety of ways that include multiple antigen peptides (MAP) and as DNA vaccines that prime for different antibody isotypes. On the immunological side we observe that: (i) depending on the immunogen formulation peptide mimetics can be processed by either CD5+ or CD5-B cells; (ii) peptide mimeotope immunization can induce cross-reactive responses to multiple carbohydrate forms; (iii) priming with peptide mimeotopes can enhance carbohydrate immune responses upon boosting and (iv) immunization with peptide mimeotopes can induce carbohydrate reactive T cells.

Amino Acid Sequence↗