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Biomedical subjects

P Lundgren

Publications and source records attributed to P Lundgren.

At least 37 records · Page 2Linked to original sources
PubMed1983

A study of routines followed and equipment used in 430 hospital wards handling antineoplastic agents.

The routines followed and the equipment used by hospital staff when handling antineoplastic drugs were studied. A questionnaire was sent via the hospital pharmacies to hospital wards which administered antineoplastic drugs at least once a week. The answers received from 430 wards indicate a good understanding and awareness of the risks. Efforts had been made to protect the personnel from potential adverse effects. Efforts had been made to protect the personnel from potential adverse effects from the medications prepared or administered. There was, however, still a shortage of protective equipment such as ventilated cabinets. Existing cabinets were often not used and maintained in a proper manner. On the basis of the responses to the questionnaire, it may be concluded that there is still a need for further evaluation of the routines used in the practical handling of antineoplastic agents in hospital wards.

Antineoplastic Agents↗
PubMed1978

Effects of anisomycin and CNS stimulants on brain catecholamine synthesis.

Mice were injected with anisomycin, an inhibitor of cerebral protein synthesis; d-amphetamine, strychnine, or caffeine was administered 30 min later. Fifteen min before sacrifice at 1 or 2 hr after injection of anisomycin, 3H-tyrosine was injected intravenously, and catecholamine synthesis rates were estimated by measurement of the specific activity of 3H-tyrosine and the accumulation of 3H-norepinephrine and 3H-dopamine. Anisomycin decreased synthesis rates of catecholamines, but this effect was not significantly affected by any of the CNS stimulants. These results suggest that the recently reported reversal of anisomycin-induced amnesia by these stimulants is not due to an attenuation of brain catecholamine synthesis inhibition.

Animals↗
PubMed1975

Mechanism of the inhibitory effect of PAS granules on the absorption of rifampicin: adsorption of rifampicin by an excipient, bentonite.

The bioavailability (plasma concentrations, AUC and urinary excretion) of an oral solution of rifampicin was investigated in six healthy volunteers. Simultaneous administration of PAS granules produced a significant decrease in the absorption of RMP, whereas Na-PAS tablets had no effect. This indicated that the dosage form of the granules and not PAS itself was responsible for the interaction, and that the dissolution of RMP was not involved. The interaction could be reproduced by giving dummy granules that contained the same excipients but no PAS. The disintegration and dissolution of PAS granules in vitro correlated well with the disappearance of RMP from the solution. The major excipient of the granules, bentonite (a mineral closely related to kaolin), was found to adsorb rifampicin rapidly and strongly.

Adsorption↗