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Biomedical subjects

P Lumbroso

Publications and source records attributed to P Lumbroso.

At least 19 recordsLinked to original sources
PubMed1991

[Intraindividual double-blind comparative study of the immediate ocular tolerability of the Na+ and Mg++ salts of N-acetyl-aspartylglutamic acid (NAAGA)].

A good immediate ocular tolerance of eye-drops is paramount for the patient's compliance, and therefore for the therapeutic success. The tolerance of a new formula of NAAXIA, an anti-allergic eye-drop, whose sole modification was the replacement of the Mg++ ion by the Na+ ion, was compared with the previous formula. One drop of each preparation was instilled in one eye so as to make an intraindividual comparison. Just after instillation, each subject was asked to express what he felt, and which eye-drop he preferred. The answers, reported on a sequential analysis graph, clearly show that in all three groups (healthy adults, red-eyed adults, red-eyed children) the slight alteration of the formula led to a marked improvement in immediate tolerance.

Adult↗
PubMed1991

[Treatment of dry eye syndrome with lacrimal gel: a randomized multicenter study].

The appearance on the French market of a carbomer tear substitute, Gel-Larmes, an original galenic form, constitutes a real therapeutic progress in the treatment of dry eye syndrome. An open randomized multicentric trial was conducted comparing the tolerance and efficacy of Gel-Larmes with those of eye drops containing chondroitin sulphate. The statistical analysis evidences an inferior average number of daily instillations for Gel-Larmes, its better efficacy on the symptoms as well as on the objective criteria: biomicroscopic examination, break-up time, rose Bengal test. The tolerance of the product is excellent and 81% of the patients express their wish to pursue Gel-Larmes versus 54% for the reference product.

Acrylic Resins↗
PubMed1985

Z helix-coil transition of d(C-Br8G-C-G-C-Br8G) studied by CD, 1H-NMR and IR spectroscopies.

The conformation of d(C-Br8G-C-G-C-Br8G) in aqueous solution was studied by CD and 1H-NMR spectroscopy and in condensed phase by IR spectroscopy. Whether in 0.1 M or 3 M NaCl solution or in film the only double helical structure adopted by brominated d(C-G)3 oligomer is the Z form. The IR spectrum of the film presents all the characteristic absorptions of the Z conformation and in particular is indicative of a syn conformation for the central guanosine as well as for the brominated one. Imino proton resonances of d(C-Br8G-C-G-C-Br8G) demonstrating the duplex formation were observed up to 60 degrees C. It is interesting to note that the significant highfield shifts of the dC H5" exocyclic sugar protons characteristic of the non exchangeable proton spectra of d(C-G)3 containing 5-methyl dC residues in the Z form were also detected in the proton spectrum of brominated oligomer. Whereas formation of the Z helix of methylated d(C-G)3 oligomers dependent on the salt concentration was found to occur via the preliminary formation of a B helix even in 4 M NaCl solution, the Z helix of d(C-Br8G-C-G-C-Br8G) is obtained directly from the coil form. However, IR data suggest that in the Z form of d(C-Br8G-C-G-C-Br8G), the overlapping of the base planes should be slightly different in comparison with the stacking observed in d(C-G)3 crystals. The kinetic data (activation energy and lifetime) of the Z helix-coil transition of brominated d(C-G)3 are compared to those of the B helix-coil transition observed for methylated d(C-G)3 in 0.1 M NaCl solution while the thermodynamic data of these two reactions (enthalpy and midpoint temperature) are slightly different.

Base Sequence↗
PubMed1985

[N-acetyl-aspartylglutamic acid eye drops in allergic-type conjuctivitis. Double-blind comparative clinical study].

Fifty patients with allergic conjunctivitis were included in a double-blind randomized clinical trial designed to compare the efficiency and tolerance of two antiallergic eye-drops: one containing NAAGA (22 patients), the other one containing disodium Cromoglycate (28 patients). Both treatments were used at a dosage of 1 drop 4 times per day. Ocular symptoms, conjunctivo-corneal signs and the subjective ocular condition assessed by the patients themselves with visual analogue scales, were all significantly improved by both eye-drops during the first month of treatment. Statistical analysis showed that patient ocular condition improved more rapidly with NAAGA eye-drops. In 25 patients (12 in the NAAGA group and 13 in the Cromoglycate group), the study was continued for an additional month according to a cross-over protocol. During the 2nd month of treatment, additional improvement of ocular symptoms and signs were observed with both eye-drops but more markedly in those patients who received NAAGA after Cromoglycate. Ocular tolerance was good for both eye-drops.

Adolescent↗
PubMed1984

Oxprenolol placental transfer, plasma concentrations in newborns and passage into breast milk.

Thirty-two pregnant hypertensive patients were treated with oxprenolol administered in combination with dihydralazine as Trasipressol tablets. Before delivery, oxprenolol was demonstrable in the maternal plasma and the amniotic fluid. The free fraction of oxprenolol in the maternal serum (15% +/- 7.8; mean +/- s.d.; n = 25) was similar to that in normal serum. At the end of delivery, oxprenolol was found in both the maternal and umbilical plasma in most cases. Measurable, but low oxprenolol concentrations were present in the newborn plasma. After delivery, oxprenolol was demonstrable in the maternal plasma and breast milk. An infant weighing 3 kg and consuming 500 ml of breast milk per day would receive a maximum dose 60 times less than the normal daily dose for a hypertensive adult (4 mg/kg).

Adolescent↗
PubMed1983

[Echographic detection of cervical incompetence. Comparison between the abdominal and perineal route].

Ultrasonographic measurements of the cervix in perineal and abdominal projections were compared in 61 women. Measured by the abdominal route the diameter of the internal os in most cases exceeded by 4 mm that measured by the perineal route, and cervical incompetence can be diagnosed when the internal os is equal or superior to 24 mm. For the abdominal measurement to be reliable the posterior vesical angle must be well marked, which means that the bladder must be moderately filled.

Abdomen↗
PubMed1983

[The cervix in primiparous women. A series of 320 perineal echographies].

Perineal ultrasound was carried out on a series of 320 primiparous women at their first antenatal visit. The results obtained show that an internal of that was larger than 20 mm was abnormal. A sign of a short cervix (less than 40 mm long on ultrasound) was of not much value but had to be taken notice of. In six cases it was found that clinically the cervix was absolutely normal and on ultrasound was incompetent.

Cervix Uteri↗
PubMed1975

[Highly hydrophilic soft lenses. Optic indications for permanent wearing and adaptation technic].

After the indications of the various contact prostheses are briefly reviewed, the interest of continuous wearing of optical hydrophilic soft lenses is emphasized. Aphakia, high ametropis and anisometropia are the main indications. Yet, continous wearing should be recommended only to patients who have difficulty with contact lens manipulation. The patient will be admitted twice in hospital for the fitting and cared for twice a day which permits to get over the difficulty of the first two nights. From the evaluation os the fitting of 33 eyes, the advantages, disadvantages, failures and complications of such a technique are discussed.

Amblyopia↗