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Biomedical subjects

P Loizzi

Publications and source records attributed to P Loizzi.

71 records · Page 4Linked to original sources
PubMed1980

A double-blind, crossover comparison between indoprofen and aspirin in rheumatoid arthritis.

Twenty in-patients with rheumatoid arthritis took part in a double-blind, crossover clinical trial to compare the effectiveness and tolerance of 400 mg indoprofen with 1000 mg aspirin each given 3-times a day for 1 week, with an interval of 2 days during which patients received an indistinguishable placebo. At the start and at the end of each treatment period several subjective and objective indices were measured. Both indoprofen and aspirin to remable improvement in patient conditions, with no significant differences between drugs in overall pain, number of swollen joints, grip strength and functional index. Indoprofen, however, was significantly superior to aspirin with regard to the number of painful joints (p < 0.01), duration of morning stiffness (p < 0.05) and articular index (p < 0.05). Moreover, both patients' and investigators' opinion of overall response favoured indoprofen. Small but significant decreases were recorded in ertythrocyte sedimentation rate and seromucoid levels in both treatment periods. Adverse reactions, mainly as gastric pyrosis and/or gastralgia, occurred in 6 patients while on aspirin, in 2 while on indoprofen, and in a further 2 while on both drugs. No statistically significant changes were observed in safety laboratory tests.

Adult↗
PubMed1980

Double-blind clinical trial of protacine versus oxyphenbutazone in rheumatic disorders.

A double-blind trial wa carried out in 30 in-patients, mainly with rheumatoid disorders, to compare the efficacy and tolerance of protacine with those of oxyphenbutazone. Patients were given oral doses either of 150 mg protacine or 200 mg oxyphenbutazone 3-times daily for 21 days. Clinical symptoms were assessed by semiquantitative scoring at 5-days' intervals. The same was done for side-effects. Protacine globally reduced the symptom scores by 55% and oxyphenbutazone by 34% (p < 0.001). Frequency and severity of side-effects were significantly less and less severe during protacine than during oxyphenbutazone treatment (p < 0.01). Physiological parameters did not vary during either treatment. Good efficacy, good tolerance and a convenient dose schedule suggest that protacine may well be suited also for long-term treatment.

Adult↗
PubMed1979

Double-blind clinical evaluation of a new anti-inflammatory drug, protacine, versus indomethacin.

A double-blind clinical trial was carried out in 69 rheumatic in-patients to compare the efficacy and tolerance of a new, non-steroidal anti-inflammatory agent, protacine, with that of indomethacin. Patients received either 150 mg protacine or 50 mg indomethacin 3-times daily for 21 days. The time course of symptoms was recorded by semiquantitative scoring, as were side-effects. Uropepsinogen excretion, occult blood in faeces and standard physiological parameters were also monitored. Protacine globally decreased symptom scores by 58.5% and indomethacin by 24.3% (p less than 0.001). The computed time to reduce symptom scores by 50% was 17.2 days with protacine as compared to 39.2 days with indomethacin (p less than 0.001). Physiological parameters did not change, except white blood cells which decreased after protacine (each subject however, remaining well within the physiological range) and erythrocyte sedimentation rate, which decreased in both groups. Uropepsinogen excretion increased by 70% after protacine, and threefold after indomethacin (p less than 0.001). Occult blood search was positive in 1 patient receiving protacine, while 2 who were already positive before receiving protacine became negative during the treatment. Four patients taking indomethacin were found to be positive, 1 showing melaena. The one who was already positive before treatment showed increasing severity of occult bleeding during indomethacin administration. Frequency and severity of side-effects were significantly less with protacine (p = 0.004). In conclusion, protacine showed analgesic and anti-inflammatory actions significantly more potent and rapid than those of indomethacin, with significantly fewer and less severe side-effects.

Adult↗
PubMed1977

Flurbiprofen in rheumatoid arthritis therapy.

Preliminary findings are reported from an open study of 300 mg flurbiprofen daily in 24 patients and from 6 out of 30 patients treated so far in a double-blind crossover comparison of 300 mg flurbiprofen daily and 150 mg indomethacin daily in the treatment of rheumatoid arthritis. The results indicate that flurbiprofen is effective in relieving symptoms and is better tolerated than indomethacin. Using an experimental model in rats to assess the anti-inflammatory activity of flurbiprofen, data suggest that flurbiprofen is unable to prevent an immunological type of inflammation but is capable of modifying the type and extent of cellular infiltration.

Animals↗
PubMedDate not supplied

[Breast cancer in pregnancy. Resistance to screening].

BACKGROUND: An increasing number of women decide to become pregnant after 30 years of age, an age which begins to superimpose that of greater incidence of breast cancer, and therefore an ever-increasing number of women are destined to become pregnant during the growth of their cancers. Pregnancy associated breast cancer has a worse prognosis, but this prognosis is caused mainly from a delay in the diagnosis; for this reason the aims of this study have been to ascertain the reasons for this delay. METHODS: A sample of 500 pregnant women at term at the age of over 30 years spontaneously applied to the II Dept of Obstetrics and Gynecology at the University of Bari, were perspectively examined through a questionnaire about non-instrumental breast checks carried out during the pregnancy. RESULTS: Only the 7.4% of the women have been subjected to breast examination during pregnancy, most (67.6%) without troubles. The habit of self-examination has fallen from 28.4% to 6.2%. A greater care for cervical carcinoma has been underlined. CONCLUSIONS: Pregnancy is a moment of less attention for the physician and patient about breast cancer, and this causes a delay in the diagnosis with consequent prognostic worsening. For this reason there must be a greater interest to this problem and a different diagnostic approach.

Adult↗