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Biomedical subjects

P Loeb

Publications and source records attributed to P Loeb.

11 recordsLinked to original sources

[Benzodiazepine withdrawal presenting as pseudo-surgical abdominal pain].

A 39-year-old patient was admitted to the emergency department for acute abdominal pain. Physical examination showed a peritoneal syndrome. However, CT-scan, Doppler and blood analysis were unremarkable. As the patient had a history of auto-medication with benzodiazepines at high doses, a withdrawal syndrome was considered. An intravenous administration of 3 mg of midazolam determined the relief of all symptoms in a few minutes.

Abdomen, Acute↗

Liver disease in extrahepatic malignancy.

The various causes of liver disease in malignancy have been reviewed. Metastatic lesions, hepatotoxicity from oncotherapeutic agents, infections, and vascular complications must all be considered. A systematic approach beginning with a detailed history and physical examination usually provides clinicians with early clues as to the etiology of the liver disease in malignancy. The advent of new laboratory tests and the technologic advances in abdominal imaging have provided powerful new tools for the diagnosis and management of patients with liver disease. Understanding how these tests could be properly used will enhance the likelihood that important liver disease will not be missed in patients with malignancies.

Humans↗

Bad blood.

Explore the source record for details and available documents.

Blood Banks↗

Colloid osmotic pressure at birth. Effect of sample site, type, and mode of delivery.

Colloid osmotic pressure was measured at birth in 102 newborns. Umbilical vein plasma colloid osmotic pressure correlated with total serum protein, birth weight, and gestational age. Mean colloid osmotic pressure of 11 infants who were small for gestational age was less than, and that of seven infants who were large for gestational age was more than, that of average-sized infants of similar gestation. For infants weighing 1,501 to 3,000 g, mean (+/- SD) colloid osmotic pressure following cesarean section (15.1 +/- 1.6 mm Hg) was lower than that following vaginal delivery (18.4 +/- 2.2 mm Hg). This may reflect the fact that use of maternal fluid therapy preceding cesarean section was greater than before vaginal delivery. The definition of normative values for neonatal plasma colloid osmotic pressure makes it possible to investigate changes in relation to disease, therapy, and subsequent outcome in sick neonates.

Birth Weight↗

Acute and subacute pancreatitis. Role of surgery and endoscopic retrograde cholangiopancreatography.

Six of seven patients with acute pancreatitis who were intractable to prolonged medical therapy underwent successful endoscopic retrograde cholangiopancreatography (ERCP) followed by immediate operative therapy. All of these patients had surgically correctable lesions consistent with chronic pancreatitis. There was one associated mortality and no morbidity. The conditions of the surviving six patients were significantly improved in the immediate postoperative period, and long-term follow-up has been encouraging. Pancreaticojejunostomy and conservative resection appeared to have good results. The timing of the operation immediately after ERCP in patients with acute pancreatic pathology eliminated problems with exacerbation or sepsis. Patients whose clinical conditions do not improve with aggressive medical therapy for acute pancreatitis may have both chronic and acute disease that is amenable to operative therapy.

Acute Disease↗

The histologic spectrum of Barrett's esophagus.

To define the histology of the columnarlined esophagus, we obtained esophageal biopsies from various levels with manometric control from 11 patients. There were three types of columnar epithelia above the lower esophageal sphincter: atrophic gastric-fundic-type epithelium with parietal and chief cells; junctional-type epithelium with cardiac mucous glands; and distinctive specialized columnar epithelium with a villiform surface, mucous glands and intestinal-type goblet cells. When present, specialized columnar epithelium was always the most proximal, and gastric fundic epithelium the most distal epithelium. Junctional epithelium was interposed between gastric fundic and specialized columnar or squamous epithelium. Four patients had unequivocal esophagitis in squamous epithelium, but its presence and severity did not correlate with inflammation in or length or type of distal columnar epithelium. Histoligic study of the columnar-lined esophagus demonstrated a spectrum of epithelial patterns. This heterogeneity helps to explain prior discrepant reports.

Adult↗