Biomedical subjects
P Lloyd
Publications and source records attributed to P Lloyd.
Relationship between the rate of appearance of oxprenolol in the systemic circulation and the location of an oxprenolol Oros 16/260 drug delivery system within the gastrointestinal tract as determined by scintigraphy.
1. The position in the gastrointestinal tract of an orally administered oxprenolol Oros drug delivery system labelled with technetium-99m DTPA was followed by gamma scintigraphy, and the corresponding plasma drug concentration-time profiles after oral and i.v. administration were used to relate pharmacokinetic and transit data. 2. Gastric emptying time (0.8 +/- 0.4 h, mean +/- s.d.), and the time to arrival in the colon (3.8 +/- 0.7 h) were reasonably consistent after administration of the Oros system to fasted subjects, as were the calculated small intestine transit times (3.0 +/- 0.7 h). As expected there were wide individual variations in colonic transit, so that recorded values for total transit ranged from 6 to 32 h (median, 24.7 h). 3. Absorption of oxprenolol occurred throughout the GI tract including the colon. Plasma drug concentration-time profiles and input functions (calculated by deconvolution) could be related to transit behaviour and in vitro release. Inflexions in the calculated rate of drug input when the Oros system was located in the colon corresponded with periods of stagnation at the hepatic and splenic flexures in two subjects and the ileocaecal junction in two others. The mechanism of these changes is unclear.
Visual neglect and extinction: a new test.
A new computerized test for visual neglect and extinction was developed and evaluated by testing twenty-five patients with right-hemisphere cerebrovascular accidents. The test consisted of a series of unilateral or bilateral lights on a semicircular array to which the subject responded by pushing a button. A computer controlled the sequence of stimuli and stored the responses. Results of the computer test were compared to conventional occupational therapy and beside clinical tests. Extinction was present in 16 subjects on the computerized test, and in 11 on the clinical test. Neglect was present in 13 subjects on the computerized test, in seven subjects on the occupational therapy test, and in five subjects on the clinical test. The computerized test was more sensitive than the other tests. On both computerized and clinical testing, all subjects with left-sided neglect also had left-sided extinction, but not all subjects with extinction had neglect. Neglect may represent a more severe manifestation of an underlying perceptual defect that produces both neglect and extinction.
Product liability guide. The Consumer Protection Act 1987 and the occupational health nurse.
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OH as a component of primary health care.
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High-performance liquid chromatographic analysis of glucose, fructose, sorbitol and low levels of the aldose reductase inhibitor sorbinil in human lens and plasma.
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Urinary excretion of non-dialysable conjugates of glucose and galactose in normal people and diabetic patients.
Urine contains non-dialysable conjugates of glucose and galactose from which the free sugars are released by acid hydrolysis. In 14 non-diabetic subjects the 24-h outputs (mean +/- SEM) were 25 +/- 3 mumol/24 h (glucose) and 109 +/- 15 mumol/l (galactose). In collections from 23 diabetic patients output of conjugated glucose was increased to 177 +/- 96 mumol/24 h but conjugated galactose was unchanged (119 +/- 10 mumol/24 h). The concentration ratio of glucosyl/galactosyl allows relative 24-h outputs of conjugated glucose to be estimated on random samples. The ratio (mean +/- SEM) was 0.24 +/- 0.01 in 27 normal men and 0.37 +/- 0.04 in 30 normal women. The mean ratio was increased to 0.72 +/- 0.20 in 56 male and to 0.51 +/- 0.07 in 17 female diabetic patients. In individual diabetic patients, the ratio was increased significantly in 28 out of 56 men and in 5 out of 30 women. In male diabetic patients the ratio was increased in 17 out of 23 Type 1 (insulin-dependent) but in only 3 out of 15 Type 2 (non-insulin-dependent) diabetic patients. There was no correlation between the glucosyl/galactosyl ratio and patient age, known duration of diabetes, or urinary excretion of free glucose or protein. Urine samples showing increased glucosyl/galactosyl ratios did not yield bacteria on culture and were negative for Candida albicans cell-wall mannan antigen. It is concluded that 80% of male Type 1 diabetic patients show increased urinary excretion of non-dialysable conjugated glucose. In women, there is much greater variation in non-diabetic subjects which may obscure an increased excretion in diabetic patients.
OH nursing in the USA. 1. Education and training.
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OH nursing in the USA. 2. Company health care in action.
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Antenatal education: does it improve the quality of labour and delivery?
Of 196 nulliparous women who delivered in a two month period, 78 percent had attended antenatal education classes. The mothers who did not attend antenatal classes consisted of significantly more Maori and Pacific Island mothers, they were younger, smoked more, had a lower socioeconomic status and fewer were married. The group who went to antenatal education classes had a significantly longer second stage in labour and required more forceps assistance during delivery compared to non-attenders. These results remained for the polynesian mothers, when they were analysed separately and the differences in age and socioeconomic status were no longer present. There was no difference in the type of pain relief required during childbirth by the attenders or non-attenders. We found no evidence that attending antenatal education classes will ensure an easy and less complicated childbirth.
Postnatal groups what format do mothers want?
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OH nursing: the international scene.
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The prevention of cross-infection in dentistry.
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Factors affecting tryptophan-induced hypoglycaemia in rats.
The mechanisms whereby tryptophan administration leads to hypoglycaemia in some groups of rats but not others have been investigated. Animals insensitive to tryptophan are rendered responsive by adrenalectomy. This effect is reversed by steroid replacement. Turnover studies with [2-3H]glucose show that hypoglycaemia in sensitive animals is associated with a decrease in glucose synthesis. Tryptophan administration causes a marked and sustained increase in plasma glucagon concentrations in all animals. The locus of the inhibition of gluconeogenesis in tryptophan-sensitive animals is the reaction catalysed by phosphoenolpyruvate carboxykinase. The sensitivities to tryptophan of gluconeogenesis in isolated hepatocytes from normal and adrenalectomized animals were similar. Cells from chronically streptozotocin-diabetic animals required higher concentrations of the amino acid for the same effect. These results are discussed in relation to previous discrepancies in the literature, and a unifying hypothesis for tryptophan-induced hypoglycaemia is proposed.