Stewart's malignant centrofacial granuloma is a rare affection. The characteristic clinical features are extensive ulceronecrotic processes affecting the upper respiratory tract, these being always unilateral, with no lymph node adenopathy spread and no visceral dissemination (confirmed in all cases in which an autopsy was conducted). There are no specific biological changes that could supply objective confirmation of the affection. The histological appearance is that of a granuloma with non-specific inflammatory signs, but having a pseudo-malignant appearance in some cases which is difficult to interpret. The true etiopathogenic nature of the lesions remains obscure. The most admitted current hypothesis is that Stewart's malignant granuloma is an immune response, in a granulomatous mode, to an antigenic stimulation, the antigen being unknown.

Facial Neoplasms↗

PubMedDate not supplied

[Scleroderma: peripheral vascular exploration by Doppler ultrasound (author's transl)].

In this preliminary study the authors consider the data that a Doppler investigation may provide for scleroderma. These data are on three levels. 1) At the diagnostic stage: in case of Raynaud phenomenon the Doppler investigation might allow to establish a diagnosis at an early stage in one of two directions:--whether a Raynaud disease, in case of a normal Doppler without taking into account its long-term future;--whether a Raynaud syndrome, in case of abnormal Doppler (thrombosis of the cubital artery or digital collaterals. Because of a recurring fact we must consider scleroderma first; 2) At the therapeutic stage, the Doppler investigation will perhaps allow to select at an early stage the patients who are able to respond to a cervical sympathectomy in a favorable way. 3) At the pathogenic stage, the Doppler investigation should allow a better selection of patients who are suspicious of being affected with a macroangiopathy has to be accurately diagnosed.

Aged↗

PubMedDate not supplied

[Scanning electron microscopic study in five cases of malignant cutaneous lymphomas].

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Humans↗

PubMedDate not supplied

[Epithelioma occurring on chronic leg ulcers (author's transl)].

The authors report nine cases of epithelioma occuring on chronic leg ulcers of venous origin (6), or on fistula from chronic osteitis (3). Compared with the other trophic leg ulcers observed during the same period, the risk of malignant change approximatly is of 0,3 p. 100. It always concerns aged caucasian subjects (about 70 years old) and the evolution last long (5/20 years), except in one of the case. The first symptoms are hard, bleeding and exuberant granulation either on the edge of the ulcer, or on the ulcer itself. It is often necessary to repeat the biopsies to obtain histological corroboration of the diagnosis. Prognosis is severe (2 lung metastasis) and amputation seems to be the best treatment.

Aged↗

PubMedDate not supplied

[Scanning electron microscopy study in 5 cases of malignant skin lymphomas].

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Cells, Cultured↗

PubMedDate not supplied

[Epitheliomatous degeneration of chronic leg ulcers. Apropos of 9 cases].

The authors report nine cases of epithelioma occurring on chronic leg ulcers of venous origin (6), or on fistula from chronic osteitis (3). Compared with the other trophic leg ulcers observed during the same period, the risk of malignant change approximately is of 0,3 p. 100. It always concerns aged caucasian subjects (about 70 years old) and the evolution lats long (5/20 years), except in one of the cases. The first symptoms are hard, bleeding and exuberant granulations either on the edge of the ulcer, or on the ulcer itself. It is often necessary to repeat the biopsies to obtain histological corroboration of the diagnosis. Prognosis is severe (2 lung metastasis) and amputation seems to be the best treatment.

Aged↗