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Biomedical subjects

P Lindsey

Publications and source records attributed to P Lindsey.

8 recordsLinked to original sources
PubMed2000

Medialization of electrode array in cochlear implantation.

In the last few years, the main thrust of research into cochlear implantation has centred around the development of advanced multi-channel implants. A new area of development is now concentrating on maximizing the potential of each individual electrode in order to improve the quality of hearing. This study involved the medialization of the cochlear implant electrode array using a silastic positioner in five patients. Two parameters were measured, namely current units needed to produce a stapedial reflex, and impedance levels between the electrode and modiolus. On insertion of the cochlear implant, readings were taken before the insertion of the positioner, immediately afterwards and at two months.

Adult↗
PubMed1991

Consent screening interview for community residential placement: report on the initial pilot study data.

A preliminary investigation of the reliability and validity of the Consent Screening Interview is described. The instrument was designed to assess the ability of adults with developmental disabilities to give direct consent for community residential placement. Our three objectives were to: (a) establish content and construct validity through administration and expert evaluation, (b) establish preliminary baseline scoring criteria; and (c) make any needed revisions based on expert appraisal and administration of the instrument to a target population. Initial results indicated that this instrument differentiated between those subjects considered competent to give consent and those whose ability to give consent was questionable.

Adult↗
PubMedDate not supplied

Computer model of the metabolism of phenylalanine in normal subjects and in patients with phenylketonuria.

The techniques of systems analysis have been applied to the metabolism of phenylalanine in healthy subjects and in phenylketonuria to derive a computer model. The model consists of seven compartments and four biological functions. Enzyme reactions are assumed to obey Michaelis-Menten kinetics. The computer program is written in FORTRAN. A biological validation of the model has been performed. The computer model has potential value for estimating concentrations of key metabolites in human organs which are not accessible to direct analysis from measurements of metabolites in blood and urine and phenylalanine intake. Such estimates would be helpful in clinical decisions concerning modification or termination of dietary treatment in phenylketonuria.

Computers↗