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Biomedical subjects

P Lindner

Publications and source records attributed to P Lindner.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Local fibrinolytic therapy of vascular occlusions in the pelvic-leg area and the upper extremity].

Seventy-three patients with vascular occlusions in the pelvis or lower limbs and three patients with upper limb lesions were treated by local low dose fibrinolysin, with strict control of any possible bleeding tendencies. Adequate recanalisation was obtained in 56 patients (73.6%). In ten patients, the occlusion recurred while the patient was still in hospital. After four to six months, 37 of the 56 (67%) of the vessels were still patent. In 18 patients, peripheral emboli resulted in some deterioration, but in 15 of these cases this could be treated successfully by operation. The methods and indications of local fibrinolysis therapy and the problems associated with it are discussed.

Adult↗
PubMed1987

[Characterization of cerebral blood flow by determining the vascular mean transit time of brain tissue using DSA].

By using a recently developed algorithm it is possible to quantify the dynamic information of a DSA sequence of the brain. The theory of algorithm allows to calculate vascular mean transit from time density curves. The algorithm minimizes the problems of densitometry with regard to "quantitative DSA". There is a strong correlation between vascular mean transit times and cerebral blood flow values, and therefore the results for mean transit times also correspond to the results obtained for cerebral blood flow. By computerized postprocessing of DSA-images it is possible to generate functional images of the brain with a spatial resolution that had not been attainable so far. The images represent the distribution pattern of reverse vascular mean transit times. The results from 36 patients with proven stenoses of the cervical vessels are reported.

Carotid Artery Diseases↗
PubMed1986

Motilin in chronic idiopathic constipation.

The plasma motilin levels were studied in seven patients with severe long-standing idiopathic constipation before and after a fat-rich test meal. The results were compared with those of a control group consisting of 10 apparently healthy persons with normal bowel function. The constipated patients had reduced basal motilin levels and a reduced motilin release after the test meal. Motilin is known to stimulate intestinal motility by inducing interdigestive descending contractions in the stomach and small intestine. A defective motilin release may therefore play a part in the pathogenesis of idiopathic constipation.

Adult↗
PubMed1986

[Varicose veins of the lung].

Varicosity of the pulmonary veins is a rare anomaly of the pulmonary vascular system. The varices do not usually change in size over years, do not cause symptoms and need no therapy. However, raised left atrial pressure can cause increase in the diameter of pulmonary vein varices. A case of lung vein varicosity in the right middle and upper lobe associated with coarctation of the aorta and an anomalous upper-middle lobe vein was observed over a period of 10 years. Increase in left atrial pressure (aortic and relative mitral regurgitation) led to enlargement of the pulmonary veins.

Female↗
PubMed1985

[Computer tomography in diagnosis of ovarian cancer].

In 90% of all cases an ovarian tumor about 2 to 3 cm in size can be visualized computertomographically using a contrast medium. Determination of the dignity can be achieved in about 81% of all cases. Malignant tumors which are impressive as smooth-walled cysts are only recognized as such in 50% of all cases. Correct staging also occurs in 50% of all cases. An accuracy of about 90% can be expected in aftercare.

Calcinosis↗
PubMed1985

[Radiologic diagnosis of metastases in the lesser pelvis].

Reviewing the literature and summarizing our own experience, the role of various imaging modalities concerning diagnosis of metastases to lymph nodes and organs in the pelvic cavity is discussed. Especially ultrasound, CT and lymphography are compared, the importance of fine-needle-aspiration is emphasized. Possible advantages of MRI are mentioned.

Female↗
PubMed1983

Parametric imaging of regional cerebral blood flow with the short-lived isotope 195mAu.

The use of the short-lived (30 s) isotope 195mAu in brain perfusion studies has been tested on 40 patients and 8 volunteers. The activity of the eluate from the 195mHg/195Au generator was high enough to give good image statistics of brain perfusion after a single bolus injection. The examinations can be repeated after 3 min giving the same quality and without significant background. The use of a low-energy photon peak at 68 keV (Au-K alpha) allows the imaging of brain perfusion in both lateral views with almost no look-through effect. With a modified height-over-area formula for the calculation of regional cerebral blood flow parametric images were obtained of high diagnostic value. The sensitivity and reproducibility of the method has been demonstrated by mental stimulation tests on eight volunteers: after optical stimulation a clear increase of blood flow could be shown in the visual cortex.

Brain↗
PubMed1983

Quantitative, non-invasive cerebral blood flow measurements with non-diffusible tracers using a heart-rate-dependent recirculation correction--application in carotid surgery.

A general method is described for computation of blood flow from time-activity curves using intravenous injection of the non-diffusible radio-tracer technetium pertechnetate. A technique of recirculation correction is adopted which predicts the start and end of recirculation depending on the patient's heart rate. This method allows one to clearly separate the first transit from the following recirculation. A correction for bolus dispersion of the intravenously injected tracer is also used. The evaluation of cerebral dynamic perfusion studies in 126 unselected adult patients resulted in a normal CBF of 44.5 ml/min/100 g +/- 5% and a decreased CBF of less than 40 ml/min/100 g. The presented method was also applied for flow measurement on the neck vessels. A good correlation between values obtained from these regions and the corresponding cerebral hemispheres was found. The method was also tested in 40 patients with angiographically proven neck vessel stenosis and in 15 patients before and after surgery of carotid stenosis. The results prove that the haemodynamic relevance of carotid stenosis on cerebral blood flow can be quantified. The accuracy of the method is estimated better than 5% for cerebral blood flow values and better than 15% for blood flow values gained over the neck vessel regions.

Adult↗
PubMed1983

Quantitative activation patterns of cerebral blood flow during mental stimulation after intravenous injection of 195mAu.

A previously reported theory for quantitative cerebral blood flow measurement for nondiffusible radiotracers has been applied to patients after stroke and to volunteers undergoing a mental stimulation exercise. Quantitative measurements of cerebral blood flow pattern in p-a and lateral projections of the brain are obtained using the short lived (30s) isotope 195mAu from the recently developed generator. The energy spectrum of the eluate from the generator shows two strong photon peaks, one at an energy level of 68 KeV and a second at 262 KeV. The low-energy peak is suitable for perfusion studies of the cerebral hemispheres in lateral projection, being without "look through" effect. The high-energy level is good for studies in the p-a-projection. Studies last less than 1 min and can be repeated after 3 min. Parametric images for quantitative regional cerebral blood flow can be generated, in which the avascular region following stroke can be detected. Quantitative activation patterns of cerebral blood flow during mental stimulation can be generated. The results show that it is possible to measure cerebral blood-flow patterns not only with freely diffusible indicators like Xenon but also with nondiffusible indicators.

Adult↗
PubMed1980

Assessment of regional blood flow by intravenous injection of 99m-technetium-pertechnetate.

A general method for computation of regional blood flow from time-activity curves obtained after intravenous injection of 99m-TC pertechnetate is presented. The method is based on the well-known principle of Meier and Zierler, but, it also considers the dispersion of an intravenously injected activity-bolus as well as the recirculation of the nondiffusible tracer. The problems arising from the use of a nondiffusible indicator concerning the partition coefficient lambda are discussed. This method of blood flow determination is adopted for measurements of cerebral blood flow and some first results are discussed.

Adult↗
PubMed1979

[Acute renal failure following general and vascular surgery (author's transl)].

From 1967 to 1976 after 25851 operations for abdominal and vascular diseases acute renal failure was found in 123 cases. In 1353 patients with gastric surgery we observed acute renal failure in 33 (2,5%), after 1499 operations on the gallbladder and bileduct in 12 (0,8%) and after 725 oprations on the colon and rectum in 40 (5,5%) cases. In almost 80% renal failure was caused by septic shock, which is the reason of the high mortality rate of 88% in our patients. It should be emphasized that only prophylaxis and immediate therapy of septic complications can lower the rate of postoperative renal failure and its letal event.

Acute Kidney Injury↗
PubMed1978

Proteolysis and flash photolysis of bacteriorhodopsin in purple membrane fragments.

Pronase treatment of aqueous suspensions of purple membrane fragments from H.halobium leads to the cleavage of bacteriorhodopsin. The protein fragments remaining in the membrane after treatment with relatively small concentrations of enzyme (2% w/w) in normal daylight range in molecular weight from 20,000--21,000 daltons, indicating that cleavage occurs mainly near the extremities of the protein chain. At higher enzyme concentrations the relative amounts of protein fragments having smaller molecular weight increase. Generally, the relative loss of retinal chromophore is larger than that of protein and thus the retinal binding site seems to be located near one of the chain ends that is cleaved off by enzyme. Irradiation with white light during the time of proteolysis (at both low and high enzyme concentrations) results in extensive cleavage, so that under certain conditions no high molecular weight components can be detected in SDS-polyacrylamide gels. It, therefore, appears that parts of the bacteriorhodopsin chain become more exposed to enzyme digestion when the purple membrane is illuminated. Enzyme treated aqueous purple membrane fragment suspensions still show photocycle activity. The main consequence of proteolysis is a pronounced appearance of biphasicity in the decay of M412 and the regeneration of bR570. Simultaneously the yield of O660 is reduced. As with untreated purple membrane, the correlation between the rates of decay of M412 and regeneration of bR570 is greatest when the yield of O660 is lowest.

Bacterial Proteins↗
PubMed1977

Kinetics of permeability changes induced by electric impulses in chromaffin granules.

Electric field pulses, ranging in intensity from 20 to 50 kV/cm and in duration from 10 to 40 micronsec, caused a transient increase in the membrane permeability of chromaffin granules from the bovine adrenal medulla, that led to partial release of granule soluble constituents. This transient permeability change was long-lived, as compared to the pulse duration, and the main part of material efflux occurred after the termination of the pulse. During the latter phase the temporarily increased permeability decayed to its original value, in the absence of the electric field. This indicated that the structural perturbation induced in the membrane was transient and apparently reversible. The release event was characterized by a field-dependent permeability coefficient ranging from 2x10(-4) cm/sec at 30 kV/cm to 3x10(-3) cm/sec at 50 kV/cm. The resealing process of the membrane could be described by two relaxation times, both of which decreased with increasing field strength. Tau1 varied from about 3.0 msec at 30 kV/cm to less than 2.0 msec at 50 kV/cm, while tau2 varied from about 100 to about 40 msec in the same interval of field strength. The distribution in the degree of filling of granules that had been partially depleted by an electric field pulse indicated that the population could be considered homogeneous with respect to release.

Adrenal Medulla↗