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Biomedical subjects

P Leonard

Publications and source records attributed to P Leonard.

At least 73 records · Page 4Linked to original sources
PubMed1979

Tricyclic antidepressants: potent blockade of histamine H1 receptors of guinea pig ileum.

Six tricyclic antidepressants were tested for their ability to antagonize histamine actions at histamine H1 receptors in a bioassay for these receptors (histamine-induced contractions of guinea pig ileum). All compounds were competitive antagonists with equilibrium dissociation constants in the range of 5.6 x 10(-11) M to 1.5 x 10(-7) M. Doxepin hydrochloride and amitriptyline hydrochloride were the most potent compounds of the series and may be the most potent antihistamines known. Antagonism at histamine H1 receptors by these compounds may explain their sedative effects.

Animals↗
PubMed1979

[Indications and limitations of surgery of the sympathetic nervous system (author's transl)].

Two types of sympathectomy are common today, the lumbar and the cervicothoracic. It is a simple operation with extremely low mortality and morbidity although the patients are frequently of an advanced age. 8--10 days after the operation pains may occur, especially at night. The authors observed them in 3--15% of cases after lumbar sympathectomy, more rarely after cervicothoracic sympathectomy. The pains usually disappear after a few weeks or months. Sexual disturbances may occur in about 10--15% of young men. Therefore in these patients the first two lumbar ganglia should be spared. Arterial obstructions above all arteriosclerotic occlusions are the most important and most frequent indications for surgery of the sympathetic nervous system. Statistics from the Strasburg Hospital yielded a total of 56% good and very good results in 666 lumbar sympathectomies, and 31.2% successes even in Fontaine's stage IVa.

Aged↗