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Biomedical subjects

P Leguit

Publications and source records attributed to P Leguit.

49 records · Page 3Linked to original sources
PubMed1982

The risk of central venous catheter-related sepsis in patients with surgical infections.

A prospective study on the incidence of central venous catheter-related sepsis (CRS) in patients with or without concomitant bacterial infections was performed. In 194 patients, 315 central venous catheters were placed, mainly for parenteral nutrition and CVP measurement. Catheter sepsis in patients with surgical sepsis was 4.0% compared with 3.6% in the non-infected group. CRS occurred exclusively in patients with an open distant infection. Subdivision of the group of patients with infection showed that those with 'open' infection had significantly more CRS than those without open wounds. The results strongly suggest an almost exclusive exogenous route for catheter contamination. It is concluded that risk of catheter sepsis is not enhanced by the presence of concomitant infections located elsewhere. The low incidence and relative benign course of catheter-related sepsis in seriously ill patients with a surgical infection tends to widen the indication for central venous catheterisation rather than to restrict it.

Catheters, Indwelling↗
PubMed1981

Peri-anal abscess--the relationship between peri-anal abscess, hepatitis B and sexual behavior.

Twenty-two patients with a peri-anal abscess or peri-anal fistula were studied selectively for the presence of HBsAg and anti-HBs. In 14 male and 8 female patients studied, the incidence of anti-HBs was 6 and of HBsAg 1. Positive findings occurred only in European male patients who invariably showed frequent homosexual contacts. It is concluded that, in homosexual patients with peri-anal abscess, the presence of HBsAg and anti-HBs should be determined as a matter of routine and all preventive measures should be taken for possible contamination with hepatitis B virus until proven negative.

Abscess↗
PubMed1978

Costochondritis of the costal arch.

Costochondritis is a rare and symptom-poor affliction which often remains unrecognized for a long time. The diagnosis depends upon the patient's history and the physician's acquaintance with the disease. Body temperature, X-ray examination including sinography, WBC count and bacterial examination may be non-informative. Local resection of the affected cartilage, excochleation, cauterisation, irrigation and antibiotic treatment most often lead only to recurrence of the ailment. The definitive treatment consists of total resection of one or both costal cartilaginous arches. The cases of two patients are described.

Aged↗
PubMedDate not supplied

Mesothelial cell adherence to vascular prostheses and their subsequent growth in vitro.

Cell seeding may decrease the thrombogenicity of implanted vascular grafts, but its application is hampered by the limited availability of autologous endothelial cells. Human peritoneal mesothelial cells have blood flow supporting qualities and are readily available. This study investigated the adherence of mesothelial cells to vascular prostheses and their subsequent growth in vitro. Circular pieces of various vascular prosthetic materials were seeded with 51Chromium-labeled mesothelial and endothelial cells and left for either 5, 15, 30, 60, and 120 minutes. The unattached cells were removed and the degree of cell attachment was measured. The number of mesothelial cells to Dacron increased during the first 60 min up to 35.2% of the seeded inoculum whereafter a plateau was reached. Scanning electron microscopy showed spread mesothelial cells adherent to the Dacron fibers. A significant increase in adherence was observed after preincubation of Dacron with 10 micrograms/mL fibronectin, but no improvement was found after preincubation with human serum albumin or gelatin. Mesothelial cells adhered better to Gel-coated than to Gel-sealed or plain Dacron. The adherence of mesothelial cells to ePTFE (Teflon) was significantly poorer. No significant differences in adherence were found between mesothelial and endothelial cells. Mesothelial cell growth on Dacron resulted in a modest increase in the number of viable cells during 27 days, which implies biocompatibility of Dacron and mesothelial cells in vitro.

Biocompatible Materials↗
PubMedDate not supplied

[Therapeutic possibilities for the diabetic and ischemic foot].

The prognosis and treatment of a diabetic foot depend on the extent of the lesions. If infected, these lesions are always mixed, secondary to aerobic and anaerobic bacteroides. The antibiotic treatment must be well adjusted and applied for a long enough time. It is absolutely necessary, for the treatment to be effective, to know the level of the ischemia in order to decide whether a lesion or an amputation scar will heal without revascularization. The author discusses various non-invasive examinations. Today, distal revascularization if possible due to new surgical techniques. But, one must emphasize that the patency of an adequate by-pass is definitely longer than the survival of a diabetic patient, in general. A accurate diagnosis and a multiudiscipline treatment will therefore improve the quality of the survival of the patient.

Amputation, Surgical↗