Heart transplantation in Paris, at "La Pitie" Hospital.
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Adolescent↗
Biomedical subjects
P Leger
Publications and source records attributed to P Leger.
[Leishmaniasis in Greece. Results of an entomological survey during June 1977 (author's transl)].
In relation with the recent outbreak of leishmaniasis in Greece, the authors undertook entomological investigations for delimiting the foci of transmission. A first survey, during june 1977, in continental Greece, gave 6 633 sandflies with 21% of P. major and 20% of P. perfiliewi. Captures are analysed for each species with systematic and epidemiological comments.
Animals↗
[Surgical myotomy of the striated sphincter of the urethra. A new sub-pubic approach. Study of the pathology of the striated sphincter in paraplegics].
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Adolescent↗
[Human herpesvirus-6 infection and hepatitis following heart transplantation].
OBJECTIVES: Human Herpesvirus-6 (HHV-6) has been implicated in hepatitis and HHV-6 infections have been reported in patients receiving heart transplants. We investigated the occurrence of such infections and their possible relation with post-transplantation hepatitis in 58 heart transplanted patients. METHODS: The titre of HHV-6 antibodies was determined by anticomplement immunofluorescence assay and compared with the titre of CMV antibodies determined by using ELISA. RESULTS: HHV-6 seroprevalence after transplantation did not differ significantly between hepatitis, control patients (without hepatitis) and the healthy general population. In three controls and five hepatitis patients we observed, after transplantation, a seroconversion or a significant increase of antibody titre which suggested active HHV-6 infection. In six cases, HHV-6-specific IgM were found whereas CMV-specific IgM were not detected. CONCLUSION: These results indicate that HHV-6 infection is frequent after heart transplantation but not in relation with hepatitis. The mechanism of this infection needs to be clarified (either primo-infection or reactivation) and the question remains whether this infection is totally asymptomatic or could induce serious illness.
Antibodies, Viral↗
[Aneurysms of the popliteal artery. Intravascular bypass using the internal saphenous vein].
We used the internal saphenous vein to create an intravascular bypass for the treatment of aneurysms of the popliteal artery. The saphenous vein was positioned within the lumen of the aneurysmal popliteal artery and in the superficial femoral artery at its origin. Two end-to-end anastomoses were made including the venous wall within the suture. This new surgical technique is based on 3 criteria. i) anatomic: the venous bypass follows the exact path as the artery since it is situated within the lumen; ii) haemodynamic: end-to-end anastomoses are used to avoid turbulence created with end-to-side sutures; iii) histologic: the venous endothelium protects better against thrombus formation ensuring good long-term permeability.
Aneurysm↗
[Intra-aortic covered endoprosthesis].
Because of the risk and complications related to surgery of the aorta, the development of new, less invasive endovascular techniques has resulted in a certain enthusiasm for these new treatments on the part of physicians and industry. The insertion of aortic stents allows the treatment of almost one half of aneurysm of the infrarenal abdominal aorta and descending aorta. The results appear to demonstrate the medium-term reliability and efficacy of these new techniques with a lower morbidity-mortality rate than that of conventional surgery. However, preoperative and intraoperative imaging plays an essential role in the success of these new methods. Finally, although the medium-term results are encouraging, the long-term outcome of these new materials is unknown, which justifies close surveillance of these patients and prospective comparative studies.
Aneurysm, Ruptured↗