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Biomedical subjects

P Lecomte

Publications and source records attributed to P Lecomte.

At least 109 records · Page 6Linked to original sources
PubMed1980

[Malignant lymphoma of the stomach].

Analysing 24 cases of gastric sarcomas of hemopoietic origin (22 non-Hodgkin's lymphomas, 2 Hodgkin's disease) and one instance of plasmacytoma, the authors review the general and radiologic characteristics of such uncommon affections. The gastric localizations of plasmocytic affections are rare, and of them, the ulcerated fungating manifestation of the lesser curvature is the most classical. In the course of Hodgkin's disease, the finding of gastric localization darkens the prognosis since it implies a Stage IV. Because of fibroblastic stroma-response, the images are radiologically similar to adenocarcinoma. On the other hand, the radiologic aspect of gastric localization of non-Hodgkin's lymphoma leads to preoperative diagnosis. -- radiologic images measuring at least 10 cm on their long axis in more than two-thirds of cases, -- clinical-radiologic discrepancy (discreet clinical findings and extensive radiologic evidence), -- infrequent stenotic varieties, -- relatively frequent combined forms (one-third of cases) and eventual simultaneous duodenal localization (about 10%).

Adult↗
PubMed1978

[Polycystic ovary syndrome (author's transl)].

Recent developments have occurred in the understanding of the physiopathology of polycystic ovary (Stein-Leventhal) syndrome. The authors describe in particular the present bio-chemical definition of so-called type I polycystic ovary syndrome: very high and anarchical secretion of LH by the pituitary, explosive response of LH during the LH-RH test, contrasting with normal levels of FSH under basal conditions and after stimulation with LH-RH. In the polycystic ovary, positive and negative feedback exerted by oestrogens at the level of the hypothalamus are intact. In particular, the administration of clomiphene results, in the majority of cases, in ovulation in patients with this disorder. The mechanisms (ovarian hyperproduction of androstenedione, increased transformation of androstenedione into testosterone then dihydrotestosterone and into androstanediol) responsible for the development of hyperandrogenism during polycystic ovary syndrome are also analysed.

Androgens↗
PubMed1978

[12 cases of polycystic ovary type 1 (Stein-Leventhal syndrome): complete hormonal study (author's transl)].

Twelve patients with clinic and anatomic features of polycystic ovary syndrome type 1 were investigated for gonadotropic and androgenic functions. Basal LH level was 3 times higher than in normal women in the beginning of follicular phase (16,2 +/- 3,0 mUI/ml). After LH-RH stimulation (100 microgram), peak LH level was excessively high (70 +/- 10 mUI/ml) whereas FSH was normal. Clomiphen citrate (100 mg X 5 days) was followed in all cases by temperature ascension and biologic evidence of luteinisation. Four pregnancies were obtained. Plasma androstenedione was elevated in most cases (320 +/- 30 ng/ml) with elevated urinary androstanediol (80 +/- 20 microgram/24 h.) These elevated levels were strikingly reduced in all cases after ethinyl-estradiol, 50 microgram X 20 days. Physiopathologic hypothesis consistent with these results are discussed.

Androstane-3,17-diol↗
PubMed1978

[Hormone receptors in gynaecology. Towards practical applications? (author's transl)].

A general review of hormone receptors in gynaecology describes the receptors of the membrane for polypeptide hormones and the receptors for steroids. The hormone stays intact in the case of the membrane receptor and activates by contact a second intra-cellular messenger which then induces protein biosynthesis. The constant of dissociation and the number of binding-sites in the human corpus luteum are established for HCG-LH during the cycle, during pregnancy or at the menopause. The working out of these receptors for levels of polypeptides by radio bio-assay gives biological specificity and radio-immunological exactness. Steroid receptors consist of a cytosol receptor which is activated and transferred to the nucleus to induce protein synthesis. They are well recognised for oestradiol and for progesterone in the endometrium and in pathological breast tissue. Variations in the cytosol receptors and the nucleus receptors are known for different phases of the menstrual cycle. Indications for hormone treatment in cancers of the endometrium and of the breast in human pathological conditions can be improved rapidly by recognition of these receptors.

Binding Sites↗
PubMed1977

[Endocrine aspects of Steinert's disease].

The authors report a case of Steinert's disease in a woman and discuss the endocrine profile of this disease after giving an account of the criteria of diagnosis. Disorders of gonad function are mild in women, primary testicular atrophy is very frequent in man with reduction in 17-ketosteroids and testosterone. Thyroid function was normal but, in a few cases, a low fixation curve was found (our case) corrected by TSH stimulation. The frequency of cataract emphasizes the interest of this sign for detection. Diabetes, associated with hyperinsulinism, seemed more frequent than in a population without Steinert's disease. The pathogenesis of these endocrine disorders appears secondary and is ill explained if one considers it as a single disease. Better knowledge, no doubt linked to progress in biochemistry of normal and myopathic muscle, will help to explain the pathogenesis.

17-Hydroxycorticosteroids↗