Biomedical subjects

P Le Bozec

Publications and source records attributed to P Le Bozec.

12 recordsLinked to original sources

PubMed1998

[Contact eczema].

Allergic contact dermatitis is a very common condition. The causative allergens may be of environmental or occupational origin. Clinical and histological lesions are not specific. Only patch testing allow the identification of the allergen. Symptomatic treatment is the same as for any eczema. The only way to obtain a total clearance is to avoid the causative allergen. Unfortunately, some of them are quite impossible to be eliminated in daily life. For this reason, some patients tend to have chronic lesions years after onset. Recent advances in the elucidation of the skin immune system may contribute to the development of new efficacious therapeutic strategic.

Chronic Disease↗

PubMed1996

[Follicular staphylococcal infections].

Staphylococcal folliculitis are a common disability in early adult life. Some patients suffer only one attack, while others continue to develop recurrences over months. In such a case, nasal carriage of staphylococcus aureus should be sought in the patients and family members. The lesions may often respond to topical antiseptics. Systemic antibiotics should only be started when furuncles are complicated. Topical antibiotics, applied to the anterior nares of patients and household carriers, seems to control recurrent infection more effectively than systemic antibiotics alone. Even so, few patients will experience recurrent lesions despite good initial response to treatment.

Adult↗

PubMed1996

[Paraneoplastic pemphigus in chronic lymphocytic leukemia].

INTRODUCTION: Paraneoplastic pemphigus is an autoimmune bullous disease described by precise clinical, histological and immunological features presented by Anhalt in 1990. Prognosis is very severe and depends on the associated neoplasia and the gravity of the mucosal damage. CASE REPORT: Paraneoplastic pemphigus was diagnosed in a 62-year-old man with chronic lymphoid leukemia. The course was favorable up to one-year follow-up after general corticosteroid therapy. DISCUSSION: This case illustrates that paraneoplastic pemphigus can be controlled by general corticosteroids and would suggest the severe prognosis may be improved.

Glucocorticoids↗

PubMed1994

[Chronic lupus erythematosus in lupus disease. Retrospective study of 136 patients].

OBJECTIVES: The aim of this retrospective study of 136 patients was to specify the natural history and the systemic prognosis of chronic cutaneous lupus erythematosus. It has been stated that in most of the cases, the disease only affects the skin. METHODS: From 10 October 1980 to 31 December 1990, 136 patients with the following criteria were included in this retrospective study: clinical signs suggestive of chronic cutaneous lupus erythematosus, characteristic histology, insufficient evidence for the diagnosis of systemic lupus erythematosus. RESULTS: The prevalence of systemic clinical involvement in the population under study was nearly the same as in the general population. The following biologic or immunologic abnormalities were quite common: leukopenia, lymphopenia, thrombopenia (significantly more frequent among patients having widespread chronic cutaneous lupus erythematosus), low titers of complement levels, positive antinuclear antibodies (usually at a low titer). Eleven out of the 136 patients developed systemic lupus erythematosus, most often over 5 years after the onset of the cutaneous lesions. Four cases out of these 11 had poor prognosis: renal and/or neurologic involvement. CONCLUSION: This data suggests that patients with chronic cutaneous lupus erythematosus could benefit from long-term follow up, since the course to systemic disease occurs in only a few. Usually, antimalarials used singly or in combination with topical steroids may lead to the clearing of the lesions. Thalidomide will occasionally be useful whenever the disease is unresponsive to the preceding measures.

Adult↗

PubMed1992