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Biomedical subjects

P Lanzkowsky

Publications and source records attributed to P Lanzkowsky.

At least 73 records · Page 4Linked to original sources
PubMed1975

Leukocyte count differences in healthy white and black children 1 to 5 years of age.

A group of 150 healthy American black children were found to have neutrophil counts significantly lower than those of a similar group of healthy American white children. Absolute lymphocyte counts were similar in the black and white children. The lower neutrophil counts in black children may represent a genetic or hitherto unidentified acquired differences.

Black People↗
PubMed1975

Organ irradiation and combination chemotherapy in treatment of acute lymphocytic leukaemia in children.

Lanzkowsky, P., Shende, A., Aral, I., Saluja, G. (1975). Archives of Disease in Childhood, 50, 685. Organ irradiation and combination chemotherapy in treatment of acute lymphocytic leukaemia in children. A total of 30 consecutive children with acute lymphocytic leukaemia (ALL) were treated from June 1971 until December 1974. Remission was induced with the use of vincristine and prednisone. After induction of remission, cranial irradiation and intrathecal methotrexate were given. Then the liver, spleen, and kidney were irradiated and 6-mercaptopurine, cyclophosphamide, and methotrexate were administered during the maintenance phase. Pulsed doses of vincristine and prednisone were administered at 10- to 12-week intervals. The patients were subdivided into two groups based on their initial white blood cell (WBC) counts: a standard risk group with an initial WBC count of less than 25 000/mm3 (25 X 10(9)/1) and a high risk group with an initial WBC count greater than 25 000/mm3 (25 X 10(9)/1). Of the 30 children entered in this study one standard risk patient died in the induction phase before attaining remission. Analysis of the results is therefore based on the remaining 29 patients, 22 standard risk and 7 high risk patients, who attained complete remission. Survival rates in continuous remission were found to be 43% of the high risk group, 88% for the standard risk group, and 77% for the combined group. Analysis of the data indicates that this therapy is unsatisfactory in high risk ALL. The results to date of this therapy for standard risk are sufficiently encouraging to continue its use in this subgroup of patients.

Antineoplastic Agents↗