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P Lanzer

Publications and source records attributed to P Lanzer.

At least 19 recordsLinked to original sources
PubMed2006

Coronary-like revascularization for atherosclerotic renal artery stenosis--results in 181 consecutive patients.

AIMS: The aim of this study was to document the early outcome of coronary-like revascularization for atherosclerotic renal artery stenosis (ARAS). METHODS AND RESULTS: A total of 181 consecutive patient, 102 men, mean age 66.1 (+/- 9.2) years and 79 females, mean age 68.4 (+/- 9.2) years and 198 lesions were treated between February 1999 and May 2004 for ARAS and retrospectively analyzed. At least one major cardiovascular risk factor was present in 179 (98.9%) patients. Pre-dilatation ARAS was 81.3+/-9.6%, 27 ARAS were 50-70% and no ARAS was <50%. 135 (68.2%) of the ARAS lesions were ostial and 63 (31.8%) were non-ostial. In 17 (9.4%) patients bilateral ARAS were present. Technical success defined as residual stenosis < or =30% was achieved in 178 (98.3%) of patients and 195 (98.5%) of lesions. In one patient (0.5%) the target ARAS could not be crossed, in two (1.1%) patients residual stenosis was >30%. No major adverse cardiac or cerebral effects were observed. In 3.9% of patients minor local complications of the access site occurred; 4 (2.2%) inguinal hematoma, 3 (1.7%) pseudoaneurysm were documented. Serum creatinine concentrations and systolic and diastolic blood pressure before and after the intervention were not statistically different. CONCLUSIONS: Coronary-like approach to ARAS revascularization is technically feasible and associated with a very low complication rate.

Aged↗
PubMed2006

Carotid-artery stenting in a high-risk patient population--single centre, single operator results.

AIMS: The aim of this study was to assess the outcome of carotid-artery stenting (CAS) in high-risk patients in routine clinical settings while excluding the impact of multiple operators and the learning curve of individual operators on the outcome, and to determine the impact of individual risk factors, including vascular multimorbidity, on the outcome. METHODS AND RESULTS: A total of 143 consecutive patients, 100 (69.9%) males and 43 (30.1%) females, mean age 68.7+/-8 years treated between February 1999 and May 2004 in the Heart Centre Coswig by a single operator for a symptomatic (n=37) and asymptomatic (n=106) on average greater than 70% (82.3+/-10.7%) or 80% (85.0+/-9.1%) NASCET carotid-artery stenosis, respectively, were studied. At least one NASCET exclusion criteria was present in 140 patients (97.9%), and vascular multimorbidity was present in 94 (65.7%) patients. In 28 (19.6%) patients there was a complete occlusion of the contralateral internal carotid artery and in 12 (8.4%) patients the procedure was performed prior to emergency coronary bypass surgery. In all, 47 (32.9%) procedures were performed without and 96 (67.1%) were performed with thromboembolic protection. Technical success was achieved in all patients. Combined neurological complications, TIA, PRIND and stroke, occurred in 5 (3.5%) patients, of which 3 (2.1%) were PRIND and 2 (1.4%) were strokes. The neurological complications were more frequent and more severe in symptomatic patients compared to asymptomatic patients (PRIND 2.7% vs 1.9%; stroke 0% vs 5.4%). In patients in whom thromboembolic protection was used, the rate of neurological complications was lower compared to those without protection (PRIND 1.0% vs 4.3%; stroke 1.0% vs. 2.1%). There was no death related to the procedure. Neurological complications were more frequent and more severe in patients with vascular multimorbidity compared to those with an isolated carotid-artery stenosis (4.2% vs 2.0%). The rate of neurological complications was similar in type II diabetics and nondiabetics (2.9% vs 4.1%). In 4.2%, minor complications related to the arterial puncture site were observed (3.5% hematoma not requiring blood transfusion, 0.7% pseudoaneurysm). At follow-up after a minimum of 6 months, 9 (6.3%) patients had died, the majority of whom had died of cardiovascular disease (3.5%). CONCLUSIONS: CAS can be performed with an acceptable risk in high-risk patients in routine clinical settings when it is performed by an experienced operator. The use of thromboembolic protection devices reduces the risk of neurological complications. Presence of vascular multimorbidity, but not diabetes, appears to increase the risk of all causes and of neurological complications.

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PubMed2004

Cardiovascular multimorbidity, emerging coalescence of the integrated panvascular approach.

Cardiovascular diseases are systemic processes frequently involving multiple vascular beds. Cardiovascular multimorbidity, arbitrarily defined as a clinically relevant disease of at least two major vascular beds in a single individual is frequent occurring in 30% to 70% of patients depending on the patient population. Management of patients with cardiovascular multimorbidity is complex requiring an interdisciplinary consensus and coordination. A panvascular concept of an interdisciplinary integrated management of these patients is introduced.

Cardiovascular Diseases↗
PubMed2003

Vascular multimorbidity in patients with a documented coronary artery disease.

Atherosclerotic artery disease is a systemic vascular disorder typically involving multiple vascular territories in the same patient. To assess the prevalence and the topographic distribution of non-coronary peripheral artery disease (PAD), cerebrovascular (CVD) and renal artery disease (RAD) in patients with an angiographically confirmed coronary artery disease (CAD) a cross-sectional survey among inpatients admitted for symptoms of CAD was performed. The relationship between CAD and multiterritory vascular disease, and the major risk factors were also assessed. A total of 1855 consecutive patients, mean age 65 +/- 10.6 years (18-92 years), 1184 (63.8%) men and 671 (36.2%) women with an angiographically confirmed CAD were studied. The patients were divided into four age groups: group A < 35 years of age, group B 35 to 54 years, group C 55 to 74 years and group D > or =75 years of age. While 1265 (68.2%) had no evidence of a relevant non-coronary artery disease, in 590 (31.8%) a significant non-coronary artery disease in at least one additional major vascular territory was documented. CAD was most frequently associated with PAD in n = 176 (9.5%) patients. In 22 (1.2%), all four studied vascular territories were significantly diseased. The prevalence of the multi-territory artery disease increased with age: lowest in group A and highest in the group D. However, the data analysis by gender revealed the highest prevalence of CAD associated with PAD and RAD, respectively, in women 35 to 54 years of age. Using the multivariant logistic regression model, type II diabetes was the only major risk factor for a multi-territory expression of atherosclerosis.

Adolescent↗
PubMed2002

[Technical aspects of MR coronary angiography].

Within the past several years, MR angiography (MRA) has experienced major technological improvements. Whereas the contrast enhanced MRA of non-coronary vessels has become established in routine clinical diagnostics, MR coronary angiography still represents technical challenges to the MR scientists and clinical investigators. To allow diagnostic quality MR coronary angiography, precise and reliable visualization of small tortuous vessels moving at fast speed is necessary. This article reviews the basic principles of MRA with special consideration to MR coronary artery imaging.

Contrast Media↗
PubMed2001

How much interdisciplinarity is required to understand vascular calcifications? Formulation of four basic principles of vascular calcification.

Four potential basic mechanisms of arterial wall calcification were identified: 1) loss of inhibitory action on crystallization of biological macromolecules, 2) nucleation of calcium phosphate precipitation by dead cells and/or their membranes, 3) autocatalytic nucleation of cholesterol by antibodies against cholesterol crystals, and 4) formation of bone-like structures in advanced atherosclerotic lesions. The relevance and interplay of these mechanisms has not yet been clarified. Their elucidation will require a concerted effort of natural scientists and medical specialists.

Animals↗
PubMed2001

Topographic distribution of peripheral arteriopathy in non-diabetics and type 2 diabetics.

Peripheral arteriopathy (PA) in type 2 diabetics carries a worse prognosis compared to non-diabetics likely related to a more aggressive course of the macroangiopathy, presence of a prominent microangiopathy and worse results following revascularizations. In addition, the presence of Mönckeberg's disease in diabetics has an additional negative impact. Interestingly, PA in diabetics compared to non-diabetics is redistributed towards periphery involving predominantly the lower leg arteries. Based on the evidence we suggest that diabetic PA represents a distinct form of a systemic vascular disease characterized by myointimal thickening of macro- and microvascular beds associated with acceleration of the common variety atherosclerosis and in some cases Mönckeberg's media sclerosis. Despite the systemic involvement specific localizing factors determine the severity and clinical relevance of the diabetic PA in individual vascular beds. In this paper some of the potential localizing factors for diabetic PA are presented and briefly discussed.

Arteriosclerosis↗
PubMed2001

Variable extension of the transitional zone in the medial structure of carotid artery tripod.

BACKGROUND: The goal of our study was to demonstrate the extension of the transitional zone (TZ) between elastic and muscular medial structure in carotid artery tripod. PATIENTS AND METHODS: A histologic study of 56 probes from 8 carotid artery tripods was performed. The probes were obtained from autopsies of 4 adults (mean age: 47.5 years, range 38 to 55 years) and were taken from 7 different topographic sites. RESULTS: At each level of the CCA (at 1 cm and 2 cm proximal to the bifurcation as well as at the bifurcation) we observed an elastic arterial type in 24 (42.8%) probes with 11 to 20 (medium 15.0) elastic fibers per view field (200 x magnification) in the media. In contrast the histologic structure of the ICA and ECA varied as follows: in 8 sections (14.3%) elastic arterial type with 11 to 16 (medium 13.1) elastic fibers, in 11 sections (19.6%) muscular arterial type with 2 to 5 (medium 3.5) elastic fibers and in 9 sections (16.1%) a transitional arterial type with 6 to 8 (medium 6.7) elastic fibers in the media. Atherosclerotic lesions have prevented the assessment of the arterial type in 4 probes (7.1%). The TZ in the medial structure of carotid artery tripods is exclusively localized in the ICA/ECA but not in the CCA. The ICA/ECA presented a TZ with a length up to 0.5 cm (4 probes; 25%), up to 1.5 cm (4 probes; 25%) and longer than 1.5 cm (6 probes; 37.5%). CONCLUSIONS: In this study we confirmed that in the carotid artery tripod, a TZ--an arterial segment with transition from elastic to muscular type--does exist, involving a variable length. Furthermore studies on the impact of the biomechanical properties of the TZ as a potential factor in atherosclerotic disease are justified. In addition, the complex biomechanical behavior of the TZ should be considered prior to interventional procedures.

Adult↗
PubMed2000

[Arteriosclerosis and media sclerosis. A comparison of 2 calcifying vascular diseases].

PATHOGENESIS: Arteriosclerosis and Mönckeberg's mediasclerosis are vascular diseases associated with calcification of the artery wall. While mediasclerosis in most cases develops in type 2 diabetic patients, arteriosclerosis is the result of a combination of different vascular risk factors. Mönckeberg's mediasclerosis typically involves the tunica media, whereas arteriosclerosis-associated calcifications primarily involve the intima. CLINICS: Isolated mediasclerosis does not cause narrowing of the blood vessel. The disease is usually asymptomatic, specific therapy has not yet been established. The involvement of the intima in arteriosclerosis finally leads to a decreased circulation.

Arteriosclerosis↗
PubMed2000

The transitional zone in the tunica media of renal arteries has a maximal length of 10 millimetres.

BACKGROUND: The goal of our study was to demonstrate and to determine the length of the transitional zone in the tunica media in renal arteries. The majority of renal artery atherosclerotic stenotic lesions occurs in this segment. PATIENTS AND METHODS: Anatomical and histological studies were performed on 26 renal arteries from 13 adults at autopsy (mean age 61.6 years, range 33 to 87 years). RESULTS: In the macroscopical examination the right renal arteries (RRA) were longer with a median 53.8 mm (range 38 to 65 mm) than the left renal arteries (LRA) with a median 47.6 mm (range 35 to 63 mm), the circumferences were nearly the same: RRA 10.9 mm (range 5 mm to 15 mm) and LRA 11 mm (range 5 mm to 15 mm). Probes for histological examinations were taken from three different regions of each renal artery (origin, 5 mm and 10 mm distal to the origin). We observed a typical elastic arterial structure at the origin and muscular types at the distal 10 mm region. At the distal 5 mm region variable ratios of elastic tissue (ET) and smooth muscle cells (SMC) were found as follows: 15 arteries presented an equal ratio of EM:SMC, 7 arteries presented ET > SMC and 4 arteries presented ET < SMC ratios. CONCLUSIONS: In this study we confirmed that in renal arteries, a transitional zone (TZ) that is an arterial segment with transition from elastic to muscular type, does exist, involving the maximal length of 10 mm. Further studies on the impact of the biomechanical properties of the transitional zone as a potential localizing factor in renal atherosclerotic disease are justified. In addition, the complex biomechanical behavior of the TZ of the arterial wall should be taken into consideration when interventional procedures are planned.

Adult↗
PubMed1998

[Mönckeberg media calcinosis].

Mönckeberg's disease (MD) is characterized by media calcinosis (MC) of the arteries of the lower extremities. MC is distinct from atherosclerosis, occurs in different vascular beds, and its etiology is unknown. Here, we report a case of a 46-year old male with no prior medical history of cardiovascular disease, no metabolic risk factors, and normal laboratory findings, who presented with accidental findings of marked diffuse calcifications along the entire course of the femoral superficial and profunda arteries on plain x-ray films. Follow-up cardiovascular diagnostics using high resolution B-mode ultrasonography, ultrafast CT, and x-ray angiography revealed extensive abluminal arterial wall calcification without evidence for premature or advanced intima-related atherosclerosis in the abdominal aorta, in the arteries of the pelvis, and the lower extremities. Calcifications were also present in the proximal segments of the circumflex and left anterior descending coronary arteries. The carotid arteries showed no calcium deposits. This observation confirms that MC may occur in the absence of secondary risk factors (primary MC) and independently of atherosclerosis. Simultaneous involvement of several vascular territories including the coronary arteries appears possible. The systemic character of primary MC is consistent with a genetical cause of this as yet poorly defined disease.

Arteriosclerosis↗
PubMed1998

[Media calcinosis from the viewpoint of the cardiologist].

Mediacalcinosis (MC) represents a disease of the muscular type arteries characterized by progredient calcification of the media. MC involves most frequently the arteries of the lower extremities. However, a more extensive disease involving the arteries of the pelvis and the abdominal aorta is common. A systemic extension of MC with the involvement of the coronary arteries has been reported, but is however, according to the present opinion, rather rare. MC occurs isolated (primary MC) as well as associated with other diseases (secondary MC). The secondary forms are most frequently due to diabetes mellitus type II and to chronic renal insufficiency and accompanying secondary hyperparathyroidism. The etiopathogenesis of MC has not yet been clarified. The recent evidence based on molecular-biologic investigations suggests an active pathomechanism of an ectopic arterial wall ossification. Genetic predisposition appears possible. The diagnosis of MC is traditionally established by conventional x-ray radiography of the pelvis-lower extremity-region. Among the newer imaging modalities, the computed tomography and the high resolution B-mode ultrasonography are of special importance. The diagnostics of coronary calcification are in descending order of importance relevant the intracoronary ultrasonography (IVUS), the electron beam computed tomography (EBT), the thorax-fluoroscopy and the thorax-radiography. For the diagnosis of coronary MC necessary arterial wall layer specific calcium detection is currently possible only with the IVUS methodology. The prognosis of the primary MC is quoad vitam good. However, the mechanic and biological effects of MC on cardiacal and vascular function have not yet been determined. The secondary MC in type II diabetics represents an independent cardiovascular risk factor. A causal therapy of MC is not known. For the clinical cardiologists, MC is of primary interest as a differential diagnosis to atherosclerosis. For the scientists, MC offers an excellent in vivo model to study processes associated with arterial wall ossifications and ageing.

Arteriosclerosis↗
PubMed1991

Sequential 2D inflow venography: initial clinical observations.

Sequential 2D inflow NMR (SDI) venography was employed to define venous anatomy and pathology in five healthy subjects and five patients, mean age 48 +/- 7 years, with documented deep vein thrombosis. SDI images were graded independently by two observers on a scale of 1,2 nondiagnostic and 3,4 diagnostic categories. All iliac and femoropopliteal SDI venograms were diagnostic. In contrast, only one out of nine calf SDI venograms was diagnostic. SDI is a promising new method to assess the proximal peripheral venous system. Improved imaging strategy is needed to produce flow images of the calf veins.

Femoral Vein↗
PubMed1991

Peripheral arterial occlusive disease: prospective comparison of MR angiography and color duplex US with conventional angiography.

Conventional angiography, two-dimensional inflow magnetic resonance (MR) angiography, and color duplex ultrasound (US) were performed on 12 patients in a blinded, prospective study. The ability to grade arterial lesions and plan revascularization interventions were compared. Arterial lesions were categorized as nonsignificant (0%-49% diameter reduction) or significant (50%-100% diameter reduction). Determination of nonsignificant and significant lesions with MR angiography was in agreement with that at conventional angiography in 100 of 140 lesions (71%). Agreement between results of conventional angiography and color duplex US occurred with 114 of 123 infrainguinal lesions (93%). Twenty-one vascular interventions were planned by using conventional angiography; there was agreement with color duplex US in 11 cases and MR angiography in five. Color duplex US performed well in the assessment of infrainguinal disease but was limited in the evaluation of iliac segments because of nonvisualization. The iliac region was visualized in more patients with MR angiography than with color duplex US, but image quality with MR angiography was inconsistent. Strategies to improve MR angiography of the peripheral vasculature merit further study.

Aged↗