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Biomedical subjects

P Langhans

Publications and source records attributed to P Langhans.

At least 19 recordsLinked to original sources

[Indications, incidence of recurrence and late results after selective vagotomy].

At the Clinic and Polyclinic for General Surgery of the Westfälische Wilhelms Universität Münster a total of 125 patients were vagotomised because of chronic duodenal ulcers during the period from 1. 1. 1973-31. 12. 1988. The case histories were analysed retrospectively. Standardised questionnaires were sent to the patients in order to gain more information about the post-operative progress and about possible complications after vagotomy had been carried out. 12.2% of the patients questioned developed a recidive ulcer 1-16 years after the operation which resulted in 8 cases in a Billroth II gastrectomy with Y-anastomosis according to Roux. 7 of the 9 recidives occurred during the first two post-operative years. The average time before relapse occurred amounts to 1.7 years in spite of drug treatment. As the initial operation was performed more than 6 years ago in 88.1% of the patients and in this respect later occurring recidives could have been detected, it is to be assumed, that relapses manifest themselves, if at all, relatively soon after the initial operation. The surgical therapy of the recidive ulcer by means of B II gastrectomy was associated with a favourable prognosis; all patients were able to resume work. A comparative analysis of the later results in 67 patients of various age structures showed that with increasing age the rate of patients who considered the operation as successful decreased. Of those up to 25 years 66.7% considered themselves as recovered, of those between 41-45 years 22.2%. It can be concluded that a selective proximal vagotomy represents a curative method in the case of chronic relapsing uncomplicated duodenal ulcers. Satisfactory results could be obtained especially in young patients who develop temporary stress ulcers. Good long-term results can be obtained here, despite the high relapse rates described in our own collective of patients as well as in literature.

Adult

[Boeck's disease with spinal involvement and retroperitoneal fibrosis].

Sarcoidosis (Morbus Boeck) is a frequently found disease of the reticulohistiocytic system. Etiology and pathogenesis were mostly unknown until today. Histologic study of sarcoidosis shown granuloma with epitheloid cells similar to tuberculosis, often with hyalinization but without cheesy necrosis. The disease mostly starts with a mediastinal and cervical lymphadenopathy. Radiographically, the disease shows three typical stages when spreading to the lungs. Bone involvement in lymphomas, especially vertebral involvement, is found to be rare. A case with an additional retroperitoneal fibrosis is reported from our own hospital.

Aged

Gastric stump carcinoma -- carcinogenic factors and possible preventive measures.

Cancer in the resected stomach has a very poor prognosis unless it is detected at the "early gastric cancer" stage. The development of gastric stump carcinoma is probably dependent on the procedure chosen for primary surgery (resection). Local irritation accompanying the execution of anastomosis is also discussed as a possible cause of malignant transformation. Surgical precautions should include the choice of methods avoiding reflux, and the use of resorbable suture material for performing an exact and well-matched anastomosis. Periodic postoperative control is essential; in addition to radiological methods, endoscopy and biopsy are indicated for adequate identification of local abnormalities and mucosal changes. Patients whose high risk was stated in previous examinations, must be re-examined at shorter intervals. Identification of changes at the early cancer stage requires close cooperation of surgeon and pathologist.

Duodenum

[Echinococcus cysticus (author's transl)].

Echinococcus cysticus is a parasite; the human organism is invaded by cysticercus of the dog tape worm. In liver 60% of all viable embryos are retained, 30% in the lung, the last 10% spread via the arterial system into all other organs. Diagnosis can be established by serology, sonography, scintigraphy as well as invasive and non-invasive radiological examinations. Case reports of 20 patients with Echinococcus cysticus are given; the disease was localized 16 times in the liver, 3 times in the lung and once in the spleen. Drugs or x-ray treatment have no sufficient therapeutical effect. Trivial trauma can cause rupture of the cysts; therefore surgery is indicated.

Adult

[Surgery in patients with obstructive jaundice caused by carcinoma (author's transl)].

Malignant disease obstructing the bile ducts is diagnosed in most cases at a time, when radical surgery is not possibly any more. Diagnostic procedures applied up to now are not suited for early diagnosis. 5 years survival rates of patients with carcinoma of the bile ducts are maximally 6%, in patients with carcinoma of the papilla 36%. In the Department of Surgery of the Münster University, 126 such patients have been treated in the recent time; in 104 cases jaundice was apparent clinically. Radical pancreatoduodenectomy could be done only in 24 patients.

Adult

[Stress-induced peptic ulcer; pathogenesis, clinical features, prevention and treatment (author's transl)].

Stress-induced ulcer is a fairly common acute erosive or ulcerative lesion of the stomach and duodenum that occurs in temporal relationship with, and in response to, stressful physical or mental situations in adults and children. Such situations may arise from surgical operations, severe injuries, especially cerebro-cranial trauma, septicaemia, during intensive therapy, in persons with respiratory or renal insufficiency, in cases of carcinoma, in moribund patients; also included, because of the identical symptoms, are ulcers developing during administration of glucocorticoids, salicylates, anti-rheumatic and anti-phlogistic drugs (pre-disposing factors). The stress-induced peptic ulcer manifests itself in haematemesis, melaena, blood in the stools and in perforation. The latter is often unrecognized because of its asymptomatic and frequently un-dramatic course. Two-thirds of the lesions are in the stomach, predominantly in the form of multiple haemorrhagic erosions; on-third of the cases are located in the duodenum, almost exclusively in the form of an acute ulceration; bleeding, due to arrosion, occurs in an high percentage of these cases. Pathogenetic factors are: shock-induced circulatory disturbances of the gastro-intestinal blood supply with necrosis of the apical mucosal cells, increased gastric acidity (increased histamine release, vagal stimulation and increased production of glucocorticoids), changes in the mucosal barrier (e.g. gastro-duodenal reflux). Cases of stress-induced peptic ulcers complicating a severe primary disease (which is often masked by the intestinal symptoms) carry an unfavourable prognosis. With conservative treatment the mortality rate is still 60 percent; with surgical treatment (neither advisable nor possible in every case) it is 40 percent.

Animals

[The multiple stomach carcinoid].

Carcinoid tumors can be found in the entire alimentary tract. Stomach carcinoids make up about 3% of all carcinoids; 0.39% of all stomach tumors are carcinoids. Multiple stomach carcinoid is a medical rarity. In spite of an invasive growth, carcinoids with a diameter of less than 1 cm are considered semimalignant, those with a diameter of more than 1 cm are considered sure malignant. There are 8 cases of multiple gastric carcinoids described in the literature. In our case we found macroscopically 31 polyps with a diameter of between 0.4 and 2 cm in the stomach. Histologically they were growing invasively with small tumor groups in the lymph ducts. Therapeutically total gastrectomy was necessary.

Carcinoid Tumor

[Juxtapapillary diverticula of the duodenum and bilio-pancreatic symptoms (author's transl)].

Juxtapapillary diverticula of the duodenum are more frequent than has been assumed up to now. Among 2100 patients undergoing duodenoscopy 135 duodenal diverticula have been found. These diverticula may cause symptoms of diverculitis as well as of bilio-pancreatic disease. Such diverticula ought to be treated by surgery. In our department diverticula are turned inward, or a papillo-diverticulotomy is done depending upon the localization of the diverticula.

Cholangitis

[Diverticula of the stomach - diagnosis of their importance (author's transl)].

Gastric diverticula may be due to dilatation or traction. 75% are found in the fundus, 15% in the prepyloric antrum. In 10% they were situated elsewhere. Symptoms are unspecific. Radiography has to be combined with endoscopic investigation of their nature. Smaller diverticula are mainly treated conservatively, the larger ones will require surgery because of chronic symptoms and complications.

Diagnosis, Differential

[Lymphogenic osteomyelitis of the foot (author's transl)].

The special way of infection of the lymphogenic osteomyelitis caused by trivial trauma is demonstrated in 4 cases. Germ ascension is done by lymphatics or fissures in the tissue, as it is well known in the panaritium ossale. The treatment consists in removing the focus of infection, irrigation-suction drainage and specific antibiotic therapy. Trivial trauma of the lower extremity should be treated according to the principles of asepsis.

Adult