Biomedical subjects
Publications and source records attributed to P Lamothe.
Ecbolic and Hormonal Action of Synthetic Prostaglandin F(2)a in Fetal Mummification in Two Holstein CowsThe effects of treatment with synthetic prostaglandin F(2)a (500mug i.m.) to correct cases of fetal mummification in two Holstein cows are described.
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The uterine secretions of 20 bovine females have been studied and the activity of the following five enzymes has been evaluated: aldolase, glucose-t-phosphodeshydrogenase (G-6-PDH), sorbitol deshydrogenase, glutamic pyruvic transminase. Significant cyclic variations have been observed for aldolase and G-6-PDH, aldolase activity being maximum during the estrogenic phase of the cycle whereas G-6-PDH activity has been more important during the progesteronic phase. These results indicate a significant uterine metabolic activity during the different phases of the reproduction processes.
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This report is concerned with a consistent problem of neonatal calf diarrhea (NCD) in a dairy herd in which, for nearly two years, the morbidity had approached 100% and the mortality had varied from 20% to 45%. Generally, diarrhea appeared at three days of age. By the fluorescent antibody tissue section technique the two Nebraska NCD viruses (reo-like and corona-like) were detected in the cytoplasm of many absorptive cells of the small intestine from a calf submitted for necropsy. Reo-like virus antigen was not detected in the absorptive and crypt cells of the colon but coronavirus-like antigen was. An adenovirus was also isolated from the small intestine of this calf. The disease was reproduced experimentally in a two day old colostrum deprived calf with a bacteria free intestinal homogenate obtained from the naturally infected calf. Both Nebraska NCD viruses were demonstrated in this experimental animal. However, the adenovirus was not re-isolated. Histological lesions observed in the small and large intestines of the naturally and experimentally infected calves were similar and because of their good correlation with the immunofluorescent findings, a combination of the two Nebraska NCD viruses was thought to be a major cause of the neonatal calf diarrhea problem afflicting this dairy herd.
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Atrial fibrillation and its treatment in a five year old purebred Holstein cow was explored with electrocardiography. Conversion of atrial fibrillation to a normal sinus rhythm was accomplished with the oral administration of a cumulated total of 125 gm of quinidine sulfate over a period of five days.
Twelve normal cows were injected with 9(alpha)F big up tri, openFAC and with 9(alpha)F, 16(alpha)m big up tri, openF. A marked increase of blood glucose and endometrial secretions glucose was noted up to the postestrus period. A more constant but lower glucose concentration was obtained with 9(alpha)F big up tri, openFAC.
The effect of two synthetic glucocorticoids, 9(alpha)-fluoroprednisolone acetate and dexamethasone (9(alpha)-fluoro, 16(alpha)-methylprednisolone) was studied on 12 normally breeding cows. Na, Mg, K, Ca and P concentrations were evaluated in the serum and in the uterine fluid at four stages of the estrous cycle. No significant changes were noted in Na and Ca concentration in either serum or uterine fluid. On the other hand, significant changes in the Mg, K and P were observed. Both drugs have caused a decrease in the content of Mg in the serum (P<0.05) during diestrus, a fall in the level of uterine K (P<0.01) during proestrus and a decrease of P during proestrus both in serum (P<0.001 after dexamethasone treatment) and in uterine fluid (P<0.001 for both drugs). It is obvious that the two drugs change the chemical composition of blood and endometrial secretions. This could jeopardize the survival of the spermatozoids and of the ovum as well as the fertilization and the implantation processes.
Total proteins, albumine and globulins of serum and uterine secretions were evaluated in two groups of 15 normal and 15 repeat breeder cows. Cyclic significant variations of all studied parameters were observed in uterine secretions of normal cows although only total proteins showed the same pattern in repeat breeder cows where individual variations were noted to be very important. Concentrations of total proteins, albumin (P<0.05) and beta globulins (P<0.01) were different between the two groups during either the estrous or the postestrous period. Concentration of proteins in uterine fluid was higher in normal breeder cows during postestrus and diestrus.
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