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P Lamb

Publications and source records attributed to P Lamb.

43 records · Page 3Linked to original sources
PubMed1969

Coproporphyria.

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Acute Disease↗
PubMedDate not supplied

A study of the probative value of Afro-Caribbean hair comparisons.

The interpretation of human hair comparisons is highly subjective and examiners tend to be cautious when evaluating positive evidence, partly because of a lack of background information relating to the interpretation of the results obtained. The purpose of this paper is to share the authors' experience of examining a large number (118) of samples of Afro-Caribbean hair. The strategy employed provided a rapid response, and only 11 (9.3%) individuals could not be excluded on the basis of hair comparison. It was concluded that not only are comparisons of Afro-Caribbean hairs possible but a significant proportion of individuals can be excluded by such tests.

Black People↗
PubMedDate not supplied

Drug discovery using receptors that modulate gene expression.

Cytokines and non-peptidyl small molecules, such as steroid hormones, exert many of their effects on cells through rapid regulation of gene expression. This is achieved by the activation of different families of latent transcription factors, which bind to specific sequences in the promoters of regulated genes. High throughput assay systems have been developed based on a detailed molecular understanding of these transcriptional regulation processes, and are being used as screens for both agonists and antagonists of specific cytokines and hormones. The opportunities for the discovery of novel and selective compounds using these systems is discussed.

Animals↗
PubMedDate not supplied

[Prognosis of severe trauma outcome using noninvasive monitoring].

The purpose of the case study was, firstly, to evaluate (starting from the time the patients are admitted to the intensive care unit--ICU) a type of cardiac, pulmonary and peripheral microcirculation in patients with severe traumas by using a multi-component and invasion-free monitoring; the second purpose was to measure quantitatively the changes in the cardiac, pulmonary and peripheral hemodynamics leading to recovery or death; and finally, it was to investigate the effectiveness of applying the discriminative analysis for the sake of assessing the biological value of the controllable changes and of forecast outcome. The invasion-free monitoring system comprising the below tools was in use: an improved bio-impedance method (evaluation of the cardiac output), pulsometry (examination of the pulmonary function), transcutaneous oxygen pressure (tissue perfusion function) and arterial blood pressure (ABP--general circulation status). The results of continuously controllable invasion-free measurements were used for a prospective evaluation at the emergency unit of the county hospital, which was supervised by the university. The accumulated integral values of the deficit or excess of each controllable parameter were calculated by using the differences between the normal values and the values obtained for each patient and for the groups of survivors and dead. A probable outcome and a degree of the deficit of the pulmonary and cardiac functions as well as of the tissue-perfusion function were analyzed by using the discriminant function. The values of pure aggregate deficits (-) or excesses (+) were for the survivors and dead, respectively, as follows: cardiac index--(+)93 +/- 49.8 l/m2 versus -232 +/- 138 l/m2 (p < 0.07); mean ABD(-)-12 +/- 12.4 mm Hg versus -57 +/- 23.5 mm Hg (p < 0.066); arterial saturation(-)-1 +/- 0.09% h versus -9 +/- 2.6% h (p < 0.001): and tissue perfusion--(+)311 +/- 87 tor/h versus 793 +/- 175 tor/h (p < 0.0001). The pure aggregate value of reduced circulation, tissue perfusion and of hypoxemia degree was found to be higher in the dead versus the survivors. The invasion-free monitoring systems secure a constant real-time control over the data, which makes the circulatory malfunction revealed as soon as possible in emergency settings. The mentioned systems can be used to describe, for each patients, a temporal hemodynamic model and to evaluate quantitatively a functional-deficit severity; they also provide for composing a clear-cut and successive treatment scheme from the emergency stage to the intensive care unit.

Adult↗