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Biomedical subjects

P Labrude

Publications and source records attributed to P Labrude.

At least 91 records · Page 5Linked to original sources
PubMed1980

[Acquired coagulation inhibitors. 10 cases (author's transl)].

A circulating anticoagulant with antiprothrombinase activity was detected in 10 patients, 4 of whom had systemic lupus erythematosus. Clinically, haemorrhages occurred only in patients with associated thrombopenia; some developed thrombosis. Recalcification time and activated partial thromboplastin time were prolonged in the patients' plasma and in mixed patients' and control plasma. In 5 cases the anticoagulant was isolated by chromatography as IgG or IgM.

Adolescent↗
PubMed1980

[Effect of the addition of albumin on the preservation of hemoglobin solutions lyophilized in the presence of glucose].

In the case of the clinical use of hemoglobin solution, the possibility of storing this preparation in the lyophilized state will be very useful. Freeze-dried preparations containing glucose alone or associated with albumin (25. 50. 75. 100 g/1) have been stored under air in darkness at room temperature or + 4 degrees C. At room temperature, the study has been stopped after one year in consideration of the important oxidation and denaturation of hemoglobin. The samples stored at low temperature have been studied after two years. With glucose alone, freeze-dried hemoglobin has generally a better stability than the four albumin containing preparations in the different assays (methemoglobin and oxyhemoglobin levels, Hill number, shape of the Barcroft's curve). The p 50 and the oxyphoric capacity are always low. Our hypothesis of an enhancement of hemoglobin stability by albumin in presence of glucose is not confirmed; the denaturation is in correspondence with the albumin concentration.

Freeze Drying↗
PubMed1979

Attempts to use carbodiimide (EDCI) to cross-link hemoglobin for transfusions.

The polymerization of hemoglobin for use as a blood substitute and an oxygen carrier would be of interest because high-mol. wt macromolecules would have a longer vascular retention time than the monomer. We found that the molecules resulting from the treatment of hemoglobin with ethyldimethylaminopropylcarbodiimide did not have a higher mol. wt than free hemoglobin and also had a dissociation curve resembling that of monomers, but seemed more stable.

Carbodiimides↗
PubMedDate not supplied

The Strasbourg's pharmacy school transfer to Nancy (October the 1st, 1872).

After a short history of the High school of pharmacy of Strasbourg and of the school of medicine and pharmacy of Nancy, and their situation in 1870, the author describes the modalities of the transfer concerning pharmacy. The first years in Nancy and the difficulties due to the existence of military fellows and to vacancy of two chairs are evocated here. The names of numerous teachers are given. The paper continues about the autonomy of the school in 1876, with the professors nominated at the chairs, with the extension of buildings and increase of students. Despite of early difficulties encountered during the settling in Nancy, it appears that the transfer from Strasbourg was a success and the school of pharmacy found rapidly its place inside the great University created in Nancy after the war.

France↗
PubMedDate not supplied

[The medicinal leech Hirudo medicinalis: clinical use of the animal and therapeutic prospects of hirudin].

Blood sucking leech, Hirudo medicinalis, used in Medicine for very long, knew an intensive employment during early 18e century but its excess was responsible of the temporary disparition of the animal from the therapeutics. Leech has currently recovered a clinical use, especially in microsurgery. On the other hand, hirudin, main active compound isolated from leech extract and also known and used for long, offers interesting outlooks by its anticoagulant and antithrombic properties. This explains the great interest of hirudin preparation by molecular genetics.

Animals↗