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Biomedical subjects

P Labelle

Publications and source records attributed to P Labelle.

30 records · Page 2Linked to original sources
PubMedDate not supplied

Ameloblastic carcinoma in a horse.

The clinical, gross morphological, histological and immunohistochemical characteristics of an ameloblastic carcinoma in a 30-year-old Quarter Horse mare are reported. This tumour was fast growing, locally invasive and destructive. Histologically, it showed an infiltrative pattern of large islands, broad sheets and, at the periphery, small cords of moderately pleomorphic round, oval to spindle-shaped cells. Immunohistochemical evaluation revealed positive labelling for vimentin, cytokeratin 5/6 and cytokeratin 14. In the oral cavity of human beings, this immunolabelling pattern is unique for the embryonal enamel organ and tumours of ameloblastomatous epithelial origin, which strongly supports the diagnosis of equine ameloblastic carcinoma.

Ameloblastoma↗
PubMedDate not supplied

[Moderate hypobaric hypoxia used as an inducer of congenital vertebral malformation in mouse embryo (author's transl)].

In 1976, we decided to review the files of the scoliosis clinic at Ste-Justine Hospital in Montreal. We found 2,237 patients with scoliosis, 212 of them are classified as congenital. At this time, congenital scoliosis were the major unresolved problems. We decided to look at an experimental model, to study the physio-pathological mechanism of the induction of these malformations. We chose the mouse as the experimental animal, and "hypobaric hypoxia" as the teratogenic agent. With this model, we can produce, malformations at different levels of the spine, if we treat at different days of pregnancy. For example, if we treat the mothers in the 10th day of her pregnancy, we get 90% of malformed embryos, at the lumbar level. All the malformations reproduced in the mice, are similar to those found in humans. We have also demonstrated no difference in the morphology of these malformations from birth to maturity, in contradiction with Epstein, who said that the majority of cleft vertebrae will disappear with bone maturation. We have also demonstrated that these malformations are present in the cartilaginous stage of development of the vertebral column. Our findings are in contradiction with Nassim's who stated, that congenital vertebral malformations are produced by an abnormal ossification process on a normal cartilage primum. Finally, our findings are in agreements with those of Dr. Uhthoff, who showed that congenital vertebral malformations are present in cartilaginous stage of development in human embryos.

Animals↗
PubMedDate not supplied

[Treatment of idiopathic scoliosis by the Harrington technique. Experience from the Ste-Justine Hospital, Montreal].

The purpose of this study was to evaluate the first seven hundred and fifty cases of scoliosis treated surgically by the harrington technique at Ste-Justine Hospital for Children in Montreal since 1964, in regards to modifications of original technique. Five surgeons were involved in the treatment. The mean presurgical angulation was 57.9 degrees; the mean post-surgical angulation was 20 degrees representing an immediate gain of 37.9 degrees. Average loss of correction three years after surgery was 13.3 degrees. Hibbs and Moe type of posterior spine fusion with fresh autogenous iliac bone appears to be the best procedure for maintenance of initial correction, together with early ambulation in a well-molded Risser-Cotrel type of plaster jacket. Prognosis as related to percentage of retained correction is better in girls than boys and also when fused after the age of thirteen years. More correction was obtained and maintained in curves between 30 degrees and 50 degrees. Rate of neurological complications was 0.4%. There was no mortality. There were 3% rod fractures, 5% pseudarthrosis proven at surgery and 5% acute or subacute infections.

Adolescent↗