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Biomedical subjects

P L Thompson

Publications and source records attributed to P L Thompson.

At least 73 records · Page 4Linked to original sources
PubMed1976

Physical examination in ischaemic heart disease.

Physical examination can yield valuable diagnostic clues in a patient suspected of ischaemic heart disease. Examination during chest pain is especially informative. The haemodynamic abnormalities which accompany angina pectoris may precipitate elevation of blood pressure, pulsus alternans, pulsus bigeminus, abnormal precordial pulsations, a fourth heart sound or a systolic bruit; all of these may subsequently disappear with cessation of the anginal attack. Careful technique of examination, especially in detecting a fourth heart sound, is essential.

Angina Pectoris↗
PubMed1976

Nitrous oxide as an analgesic in acute myocardial infarction.

Nitrous oxide in a concentration of 35% has been shown to ameliorate the pain of acute myocardial infarction. This conclusion was reached on the basis of a double-blind study in 69 patients and a clinical study in an additional 42 patients. The use of nitrous oxide was not accompanied by hemodynamic changes or significant adverse reactions.

Acute Disease↗
PubMed1976

The heart attack and doctor/patient communication.

In patients with recent proven or suspected myocardial infarction, understanding of the nature of a heart attack was explored. A wide range of misconceptions, some of them frightening, was revealed; there was a poor understanding of some terms commonly used in discussion with patients; the potential for creation of new misconceptions by doctors and nurses was highlighted.

Attitude to Health↗
PubMed1976

Coronary occlusion before, during, and after strenuous exercise.

Groups of dogs were exercised immediately before, and immediately after occlusion of the left anterior descending coronary artery. Coronary occlusion by a staged procedure resulted in a low mortality and rare ventricular ectopic beats. The combination of simultaneous exercise with coronary occlusion reproducibly provoked ventricular fibrillation (VF). Exercise before and after occlusion frequently produced ventricular tachycardia but no VF. The risk of major arrhythmias was related to the peak heart rate resulting from the exercise.

Animals↗
PubMed1976

Acute myocardial infarction: one year follow-up of 1138 cases from the Perth Community Coronary Register.

The one year mortality of patients from the Perth Acute Myocardial Infarction Register surviving the acute episode (first 28 days) is presented. Of 1138 patients suffering definite or possible acute myocardial infarction in one year, 705 (62%) survived 28 days. There were 89 deaths (11-5%) in the subsequent 11 months. One year mortality was related to age but not sex, previous symptoms of coronary heart disease, but not hypertension or diabetes, to tachycardia and congestive cardiac failure at first examination, but not arrhythmias in the acute episode. These observations highlight the importance of protecting the myocardium in the acute phase of myocardial infarction.

Acute Disease↗
PubMed1976

Acute myocardial infarction. Evaluation of praecordial ST segment mapping.

In 38 patients with acute anterior myocardial infarction or ischaemia, the extent and amplitude of ST segment elevation was measured on the chest wall with a praecordial mapping technique. There was a poor correlation with measurements of clinical severity and with the extent of necrosis as measured by the peak levels of creatine kinase (CK) and the estimated total amount of CK released. In two patients ST segment re-elevation occurred without re-elevation of serum CK and in two other patients reinfarction obvious on enzyme re-elevation occurred without changes in ST segments. Praecordial ST segment mapping appears to have a limited role in measuring or monitoring human infarct size and would be an unreliable tool for evaluation of methods to limit myocardial necrosis. The chest leads of the standard 12-lead electrocardiogram provided sufficient information for clinical evaluation of ST segment elevation.

Creatine Kinase↗
PubMed1970

Clinical experience with dextro-alprenolol.

Experience with dextro-alprenolol in nine patients has shown that it is relatively ineffective in treating arrhythmias associated with acute myocardial infarction. Marginal effectiveness in the control of ventricular ectopic beats after myocardial infarction is outweighed by an appreciable hypotensive effect with risk of infarction. The drug was ineffective in the management of supraventricular arrhythmias.

Acute Disease↗