Search PubMed⌕ Search

Biomedical subjects

P L Berry

Publications and source records attributed to P L Berry.

23 records · Page 2Linked to original sources
PubMed1982

Reduced alternative complement pathway control protein levels in anorexia nervosa: response to parenteral alimentation.

Serum levels of 16 proteins, including 11 component and control proteins of the complement system were determined before and after nutritional repletion in five female patients with severe malnutrition secondary to anorexia nervosa. Before parenteral alimentation significantly decreased serum levels were found for IgG, IgM, transferrin, Clq, C2, C3, factor B, beta lH, C3b inactivator, properdin, and C4 binding protein. A significant increase in posttreatment serum levels compared with pretreatment levels were found for transferrin, C3, factor B, beta lH, and C3b inactivator. Of the proteins measured, the C3b amplification loop control and component proteins, beta lH, C3b inactivator, C3, and factor B rose to the normal range in response to therapy most rapidly. In the absence of an acute phase reaction, these proteins appear to be particularly good indices of malnutrition and its response to therapy.

Adolescent↗
PubMed1982

The use of an anaerobic incubator for the isolation of anaerobes from clinical samples.

An anaerobic incubator was compared with a standard jar system for the isolation of anaerobes from clinical material. Seventy specimens were selected as likely to yield anaerobes: 342 different anaerobes were isolated in the incubator and 347 in anaebrobic jars. These included Bacteroides spp (43%), Peptococcus spp (26%), Peptostreptococcus spp (13%), Veillonella spp (7%), Fusobacterium spp (7%), Clostridium spp (2%) and miscellaneous Gram-positive nonsporing bacilli (2%). Differences in isolation rates for each system were inconsistent and minor. Sixteen anaerobes were chosen for quantitative tests at the beginning and end of the study period. Miles and Misra counts showed a slight advantage of the incubator for F nucleatum, but no difference for B fragilis, B thetaiomicron, B uniformis, B bivius, B corrodens, F mortiferum, Ps anaerobius, P prevotii or Propionibacterium acnes. In almost all cases, colonies in anaerobic jars were slightly larger than those in the incubator. Disc antibiotic sensitivity tests gave the same results in each system, at the beginning and end of the study period. The anaerobic incubator provides an effective means of isolation of anaerobes in a clinical laboratory. However, several design features of the prototype would require change if the system were introduced.

Anaerobiosis↗
PubMed1982

Gentamicin disposition in children with chronic renal failure.

Gentamicin (G) disposition in six children with stable chronic renal failure (CRF) and in nine children with normal renal function (NRF) was determined by pharmacokinetic analysis of serum G concentration versus time data obtained over an 8-hour period following the administration of an intravenous loading dose. ES-TRIP curve fitting indicated that G disposition was best described by a biexponential function; however, a one-compartment open model also suitably characterized G disposition for an 8-hour period. Peak serum G concentrations were similar between the CRF and NRF groups, but concentrations were significantly different (P less than 0.005) at 8 hours following the loading dose. Also, significant differences (P less than 0.001) were found between the two groups for beta, t1/2 beta, plasma clearance, and k10. The relationship of creatinine clearance (Clcr) versus beta, described by the equation beta = 0.033 + 0.003 X Clcr (P less than 0.005, r = 0.97) permitted the best prediction of the G elimination constant from a parameter of renal function. This relationship remained linear over a broad range of Clcr values in our patients and in other previously reported children with CRF and NRF.

Adolescent↗
PubMed1981

Membranoproliferative glomerulonephritis in two sibships.

In one sibship, a brother had membranoproliferative glomerulonephritis (MPGN) Type III and a sister, Type I. In both children, clinical and laboratory manifestations were typical. In another sibship, both boys had Type I MPGN by glomerular morphology but over a 4 year period of follow-up, neither had hematuria or hypocomplementemia, both common manifestations of this type. Several other reports give suggestive evidence of MPGN in siblings but details are scanty. The familial nature of the disease adds to the earlier observation of its predilection for the white race to strengthen the concept that genetic factors are involved in its origin.

Child↗