Biomedical subjects
Publications and source records attributed to P Kurka.
Acute oral intoxication with inorganic mercury compounds (in particular mercury bichloride sublimate) is characterized in particular by corrosion of the mucous membranes of the digestive tract associated with necrotizing sublimate nephrosis, with microscopically selective necrosis of the proximal tubule cells. Toxicological analysis of the affected organs (stomach, oesophagus) confirms the diagnosis.
The release from a matrix (polyethylenmineral oilgel, Plastibase) with drug (bupranolol) in suspension can be controlled by a controlling layer of the same material which is saturated with the drug. Thus, after a burst period zero order release is reached from the laminate, before square root t-kinetics predominate. The duration of constant release may be extended with fillers in the controlling layer (glass beads, d less than 20 microns). Increasing the thickness of the controlling layer increases both duration of constant release and time to reach it, the latter to a lower extent.
The drug release from an ointment that contains dissolved drug depends on the kind of preparation and on the time of storage. This indicates a relationship between shear treatment (disruption of the gel matrix) and liberation rate. With increasing storage time of the ointment the liberation rate decreases due to the increasing diffusional resistance of the reforming gel matrix.
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Explore the source record for details and available documents.