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Biomedical subjects

P Kralik

Publications and source records attributed to P Kralik.

10 recordsLinked to original sources
PubMed1982

Effects of neuroleptics on platelet monoamine oxidase activity.

Platelet MAO activity in schizophrenics was significantly decreased, by about 15%, after 3 weeks of treatment with haloperidol. Treatment with thioridazine or butaperazine also tended to decrease platelet MAO activity. The neuroleptic-induced decrease began to appear within a few days of treatment and did not show tolerance over 1-2 months of treatment with haloperidol. Platelet MAO activity of schizophrenic patients measured during drug-free base-line was not significantly different from that of normal controls, but MAO activity of schizophrenics was significantly lower than normals after 3 weeks of treatment with neuroleptics. The extent of decrease in platelet MAO activity correlated negatively with base-line prolactin and its increase after 24 hr. With PEA as substrate, the decrease in activity correlated positively with steady state plasma haloperidol.

Adult↗
PubMed1981

Catecholamines and monoamine oxidase activity in anxiety.

Levels of platelet monamine oxidase activity, state anxiety and trait anxiety were quantified twice in 20 drug-free subjects with generalized anxiety and an equal number of healthy drug-free controls at 4-week intervals. Fifteen subjects in each groups also had plasma epinephrine and norepinephrine measured. The index group received relaxation training during the interval between the two evaluation sessions. Post-relaxation training values for monoamine oxidase, epinephrine, norepinephrine and the anxiety levels were found to be significantly lower than the pre-treatment values for the index group. No significant changes were seen in the control group values. For the index group, catecholamine levels and monoamine oxidase activity were seen to correlate significant before and after relaxation training.

Adult↗
PubMed1981

Anxiety and platelet MAO levels after relaxation training.

The authors measured platelet MAO activity with phenylethylamine and tryptamine substrates in a group of 20 subjects with chronic anxiety before and after they underwent relaxation training. Levels of anxiety were quantified using a self-rating scale. Posttreatment values for anxiety and enzyme activity were significantly lower than pretreatment values. Anxiety and enzyme activity levels were not significantly correlated at any stage of the study.

Adult↗
PubMed1980

Catechol-O-methyltransferase and catecholamines in anxiety and relaxation.

Levels of anxiety, plasma epinephrine and norpinephrine, and red blood cell (RBC) catechol-O-methyltransferase (COMT) activity were measured before and after 4 weeks of relaxation training in a group of 15 drug-free, anxious subjects and at a similar interval in a group of 15 drug-free, healthy controls. The index group showed significant decreases in levels of anxiety and plasma epinephrine and norepinephrine after treatment. No changes were observed in the control values. RBC COMT did not show any significant differences in activity between the index and control groups and between the pre- and posttreatment values. Similarly, COMT activity levels failed to correlate with levels of anxiety and catecholamines before or after treatment. These findings indicate that anxiety is unlikely to have an effect on RBC COMT activity, whereas it has a direct effect on plasma catecholamines.

Adult↗
PubMed1980

MAO, DBH and COMT: the effect of anxiety.

Anxiety, a common accompaniment of depression, can be a source of confusion in affective disorder research. The present study examined the effect of anxiety on platelet monoamine oxidase, RBC catechol-0-methyltransferase, and serum dopamine-beta-hydroxylase-enzymes frequently implicated in affective disorders. Levels of anxiety, plasma catecholamines and the enzymes mentioned above were quantified in groups of anxious subjects and mentally and physically healthy controls. Anxious subjects were found to have significantly higher levels of blood plasma catecholamines and platelet monoamine oxidase. significant positive correlations were demonstrated between plasma catecholamines and platelet monoamine oxidase, while significant inverse correlations were found between trait anxiety and COMT, norepinephrine and DBH, and COMT and DBH

Adult↗