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Biomedical subjects

P Kostova

Publications and source records attributed to P Kostova.

9 recordsLinked to original sources
PubMed2000

[Endometrial cancer: a current therapeutic and diagnostic protocol].

In the presented methodical scheme, consecutively and systematically are scrutinised the epidemiology, the risk factors, the etiopathogenesis, the histopathology and the clinical signs of the endometrial cancer. The diagnostic possibilities, as well as the staging principles are pointed. The current treatment tactics, therapeutic schemes according to the stage and follow-up corresponding to the requirements of the oncological doctrine are presented.

Clinical Protocols↗
PubMed2000

[Effectiveness of cervical screening - expectation and reality].

The aim of the present study was to establish the effectiveness of the conducted in Bulgaria cervical screening program for the period 1975-1996. The dynamics of the ratio invasive cancer/in situ cancer, as well as the share of the diagnosed from cytologically signalized women were analyzed. The tendency of deterioration of each of the indices was evident. The crude incidence varies between 12.7 and 22.7 x 10(5) women, while the frequency of CIS is from 3.2 and 6.2 x 10(5) women. This defines unfavorable ratio of the cases with invasive cancer toward CIS, which varies from 2:1 for 1982 to more than 5:1 for 1996 year. The study demonstrates the prevalence of a low rate of confirmed by biopsy, cytologically signalized women--from 15.6% and 30% (total for country--33.3%), except DOD Blagoevgrad--50.6%, Plovdiv--46.4% and Sofia-city--63.8%. The results of our study demonstrate the low effectiveness of to date conducted cervical screening program. The lake of a screening register is another weakness of the program, which lead to a deteriorated registration and reading of the detected precancer lesions, as well as, their diagnostic follow and therapy.

Biopsy↗
PubMed2000

[Cancer of the vulva: modern diagnostic and therapeutic principles].

In the presented methodical sceme, consicutively and systematically are scrutinized the epidemiology. The risk factors, the etiopathogenesis, the hostopathology and the clinical signs of the vulvar cancer. The diagnostic possibilities, as well as the staging principles are pointed. The current treatment tactics, therapeutic schemes according to the stage and follow-up corresponding to the requirements of the oncological doctrine are present.

Antineoplastic Agents↗
PubMed1998

[The screening and diagnosis of ovarian cancer].

The ovarian cancer represents important medico-social problem for our country due to its significant frequency (26.1%) and high mortality (9/1000) among the oncogynecological diseases. The aim of the present review was to discuss the methods--for diagnostics of the ovarian cancer trough analyzing the possibilities for their implementation as a screening in the clinical practice. It is pointed out, that the secondary prophylaxis for ovarian cancer has its place as a selective screening for women with high risk. The proposed scheme includes: gynecological and ultrasound checks up and CA-125 investigation every two year after twenty-five ages of the woman.

Adult↗
PubMed1998

[Cervical screening--its essence and quality-control methodology in cytology laboratories].

The essence and importance of the quality control in the activity of the cytological laboratories, fulfilling the 1st step of the cervical screening are discussed. The methodology is presented, as well as the possibilities of the different kinds of internal and external control and the place of the introduced in the practice of the developed countries automated analyzing systems are under consideration.

Cytological Techniques↗
PubMed1998

[Cervical screening in Bulgaria. An analysis of the basic indices over the period 1970-1994].

The aim of the present study was to analyze the results from the cervical screening in Bulgaria for the period 1970-1994, by studying the following indicators: incidence, mortality, frequency of carcinoma in situ and stage distribution of the cases with invasive cervical cancer. The relatively constant incidence and mortality until 1987 were evident, after that they shoved increasing and for 1994 they are 19.7% and 7.6% respectively. The similar is the data for the correlation carcinoma in situ/invasive cancer and for the stage distribution of the cervical cancer patients. The obtained results showed, that cervical cancer remain medico-social problem for our country, because the introduced in 1970 cervical cytological screening at the moment is not effective enough.

Bulgaria↗
PubMed1997

[Does cytological screening have a place in sexually active teenagers?].

UNLABELLED: The aim of the present investigation is to determine what is the place of cytological screening of the uterine cervix in sexually active teenagers. MATERIAL AND METHODS: The study was based on 83 girls aged between 14 and 19 (mean age 18.13 years) without childbirth in history, who visited our clinic with non-specific gynecological complaints. All patients were submitted to brush cytology applying the classical method and classifying the smears according to the Bethesda system (1991). RESULTS AND DISCUSSION: A high adequacy of the cytologic smears was found, reaching up to 98.8% and the following distribution of the findings according to the various criteria was observed: cells within normal limits in 34.1% of the patients, benign cellular changes due to reactive changes associated with inflammation in 34.1%, atypical epithelial cell abnormalities of undetermined significance in 18.4%, low grade SIL with HPV in 11.0%, without HPV in 1.2% and high grade SIL in 1.2% of thr patients. The role of cytological screening in sexually active adolescent girls is discussed in the context of the obtained results.

Adolescent↗
PubMed1994

[The use of the Bethesda-terminology cytological system in clinical practice. A pilot study].

The aim of the present study is to summarize the one-year experience in applying the Bethesda terminological system (BTS) for assessment of cervical cytology. The study was based on 164 women, aged from 18 to 45, of which 98 with early pregnancy and 66 not pregnant. The materials for cytological examination were prepared by classical techniques and then coloured with hemalaun-eosin. Cytological findings were interpreted according to the revised BTS (1991), and an assessment of the adequacy of smears, possible infectious and reactive changes was made. Intraepithelial lesions were classified in two categories--low and high grade lesions. The advantages and shortcomings of the proposed new terminological, cytological classification system for assessment of the uterine cervix are discussed.

Adolescent↗