Biomedical subjects

P Knauth

Publications and source records attributed to P Knauth.

At least 19 recordsLinked to original sources

PubMed2006

Local atomic and electronic structure in nanocrystalline Sn-doped anatase TiO2.

Tin-doped anatase TiO(2) nanopowders and nanoceramics with particle sizes between 12 and 30 nm are investigated by X-ray absorption fine-structure (EXAFS) and Mössbauer spectroscopies. Furthermore, ab initio calculations based on the density functional theory are performed to analyze changes in the electronic structure due to Sn doping. The three approaches consistently show that Sn is dissolved on substitutional bulk sites with a slight increase of the bond lengths of the inner coordination shells. The Debye-Waller factors show that the nanocrystallites are highly ordered. There is no indication of defect states or bandgap changes with Sn doping.

Journal Article↗

PubMed2006

Thermal stability and thermodynamic properties of hybrid proton-conducting polyaryl etherketones.

The thermal and structural stability of sulfonated cross-linked PEEK (polyether ether ketone) and its silicon-containing class II hybrid derivatives were characterized by combination of mass spectrometry, infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and differential scanning calorimetry. Thermodynamic properties of the hybrids were determined, including glass-transition temperature, degree of crystallinity, and thermal stability. The decomposition processes of the hybrid polymers could be consistently interpreted and their energetics quantitatively determined. The introduction of inorganic silanol moieties improves the thermal stability compared to sulfonated products.

Electric Conductivity↗

PubMed2002

[Shiftwork].

First the most important problems of shiftworkers are discussed, i. e. living against the "inner clock", disturbances of sleep and appetite, gastrointestinal complaints, diseases, disturbances of the social life, faults and accidents. Thereafter a list of potenzial measures to reduce the problems of shiftworkers is presented and one measure -the design of shift systems according to new ergonomic recommendations- is explained.

Circadian Rhythm↗

PubMed2001

Strategies for the implementation of new shift systems.

Implementation barriers may be caused by deficiencies in the knowledge, skills, motivation, or support of those involved in the process of implementation of a new shift system. There is no 'one and only' way of planning and implementing a new shift system. However, if the following factors of success are taken into consideration there is a better chance that workers will accept a new shift system: worker participation, information, communication, training, promoter commitment, professional project management, tailor-made solutions and an adequate organizational framework. These factors are particularly relevant in addressing barriers to the implementation of new shift systems. The most important measures to cope with resistance to change of shift systems are: worker participation, information, communication, training, promoter commitment, professional project management, tailor-made solutions and an adequate organizational framework.

Adaptation, Psychological↗

PubMed2000

On the mechanism of action of the myxobacterial fungicide ambruticin.

The myxobacterial fungicide, ambruticin, kills the yeast, Hansenula anomala, with high efficacy (MIC 0.05 microg/ml), but only when the cells are growing. The earliest effect, observed almost immediately after the addition of the antibiotic, is a transient but substantial increase of intracellular glycerol, followed by an accumulation of triacylglycerols and free fatty acids. At about the time when free fatty acids accumulate, the cells become leaky to low molecular weight compounds. We assume that this leakage kills the cells. The mechanism of action of ambruticin thus appears to be the same as that of the phenylpyrroles, e.g., pyrrolnitrin, viz., interference with osmoregulation.

Antifungal Agents↗

PubMed1998

Innovative worktime arrangements.

New worktime models can be introduced from an employer's point of view for many reasons. They can extend operational time for better utilization of expensive equipment, provide customer-oriented service hours, adjust operational time to the varying needs of personnel, adhere to a given operational time despite a reduction in workhours, avoid dismissals, or improve job attractiveness for qualified personnel. On the other hand, there are also many reasons for changing traditional worktime models from an employee's point of view. For example, new models can help fit private needs to occupational demands, change worktime according to life's phases, provide more autonomy for the organization of worktime or the choice of worktime model, and allow for reduced capacity due to illness or age. The paper primarily presents examples of innovative worktime models (eg, annual worktime, time-autonomous group, variable worktime, choice between different worktime models) but also discusses the possible negative effects of new worktime arrangements.

Humans↗

PubMed1998

Knowledge-based support for the participatory design and implementation of shift systems.

OBJECTIVES: This study developed a knowledge-based software system to support the participatory design and implementation of shift systems as a joint planning process including shift workers, the workers' committee, and management. METHODS: The system was developed using a model-based approach. During the 1st phase, group discussions were repeatedly conducted with 2 experts. Thereafter a structure model of the process was generated and subsequently refined by the experts in additional semistructured interviews. Next, a factual knowledge base of 1713 relevant studies was collected on the effects of shift work. Finally, a prototype of the knowledge-based system was tested on 12 case studies. RESULTS: During the first 2 phases of the system, important basic information about the tasks to be carried out is provided for the user. During the 3rd phase this approach uses the problem-solving method of case-based reasoning to determine a shift rota which has already proved successful in other applications. It can then be modified in the 4th phase according to the shift workers' preferences. The last 2 phases support the final testing and evaluation of the system. The application of this system has shown that it is possible to obtain shift rotas suitable to actual problems and representative of good ergonomic solutions. CONCLUSIONS: A knowledge-based approach seems to provide valuable support for the complex task of designing and implementing a new shift system. The separation of the task into several phases, the provision of information at all stages, and the integration of all parties concerned seem to be essential factors for the success of the application.

Artificial Intelligence↗

PubMed1997

Changing schedules: shiftwork.

A "tailor-made" shift system should be a compromise between the employers' goals, the wishes of the employees, and ergonomic recommendations for the design of shift systems. Many traditional shift systems all over the world do not correspond to the ergonomic recommendations, which are summarized in this chapter. With six practical examples of shift systems it is shown how the recommendations may be realized. If a high acceptance of a new shift system is to be reached, a participatory process of designing and implementing the new shift system is as important as the characteristics of the new shift system itself.

Circadian Rhythm↗

PubMed1996

Designing better shift systems.

The results of some intervention studies on the effects of the change from weekly rotating to quicker rotating shift systems are presented. Consequently, the following recommendations for the design of shift systems according to physiological, psychological and social criteria are discussed: (1) Nightwork should be reduced as much as possible. If this is not possible, quickly rotating shift systems are preferable to slowly rotating ones. Permanent nightwork does not seem to be recommendable for the majority of shiftworkers. (2) Extended workdays (9-12 hours) should only be contemplated when the nature of work and the workload are suitable for extended working hours, and the shift system is designed to minimize the accumulation of fatigue and toxic exposure is limited. (3) An early start for the morning shift should be avoided. Flexible working time arrangements can be achieved in all shift systems. The highest flexibility is possible in the so-called 'time autonomous groups'. (4) Quick changeovers (e.g. from night shift to afternoon shift on the same day) should be avoided. The number of consecutive working days should be limited to five-seven. Every shift system should include some free weekends with at least two consecutive days off. (5) The forward rotation (phase delay, clockwise rotation: morning/evening/night shift) would seem to be most preferred.

Journal Article↗

PubMed1995

Speed and direction of shift rotation.

This review paper deals with the issue of shift rotation, i.e. the number of consecutive shifts of the same type and the order of change between shifts. To minimize the disturbances of the circadian system and the accumulation of sleep deficits, rapidly and clockwise-rotating shift systems would seem to be preferable. Regarding consecutive night shifts, a week of night shifts seems to be the worst system with regard to performance and accidents. There is a lack of reliable data on the effects of permanent vs. rotating-shift systems on alertness, performance and accidents. This is also true for the comparison of forward (delaying) and backward (advancing) rotating-shift systems, although the former would seem to be associated with fewer problems. For both systems, controlled longitudinal studies are necessary.

Journal Article↗

PubMed1995

[Shift work systems from the chronobiological viewpoint].

First important stresses and strains of shiftworkers are shortly presented. Thereafter the following recommendations for the design of shift systems from the chronobiological point of view are explained: 1) The shift system should have only few night shifts in succession (maximum 3) and morning shifts should also rotate quickly. 2) The morning shift should not begin too early and 3) the forward rotation (MEN) is more favourable than the backward rotation of shifts (NME). Finally 3 cases from the industry are presented, in which these recommendations have been realized.

Biological Clocks↗

PubMed1994

Effect of masking on circadian adjustment and interindividual differences on a rapidly rotating shift schedule.

OBJECTIVES: The aim of the present study was to define the effect of masking on the estimation of circadian adjustment of and interindividual differences between nurses on a rapidly rotating shift schedule. METHODS: The phase shift of the circadian rhythm of rectal temperature was studied in 17 subjects. The following three different methods for estimating the circadian phase shift were compared: (i) cosinor analysis, (ii) a method using normative endogenous data in which the masking effects are removed ("purification"), and (iii) a method using normative endogenous data in which the masking effects are not removed. RESULTS: The mean phase delay during the second night shift (compared with the morning shift) was 6.3 h according to the cosinor analyses of the raw data and 6.2 h according to the cross-correlation method of the raw data. When the masking effects were removed ("purification"), the phase shift was only 1.7 h. Diurnal type did not significantly explain the differences between individuals in the amount of phase shift of the raw data but was the only significant factor, explaining 32% of the variation between individuals in the phase shift of the purified data. CONCLUSIONS: Masking effects on body temperature should be taken into account before any definite conclusions can be drawn about the relation between individual factors and the adjustment of the circadian rhythm of body temperature.

Adaptation, Psychological↗

PubMed1992

The relation of shift work tolerance to the circadian adjustment.

The amplitude and phasing of circadian rhythms are under discussion as possible predictors of tolerance to night work. In a field study, subjective sleepiness and oral temperature of 147 female nurses were measured at 2-hour intervals during a period with one morning shift and two consecutive night shifts. The nurses also filled out a questionnaire. Two types of tolerance indices were constructed: The "health index" was based on questions referring to general fatigue, gastrointestinal symptoms, and sleep disturbances, and the "sleepiness index" on the actual subjective ratings of sleepiness. According to the health index, the group with good tolerance had a larger circadian amplitude of the oral temperature rhythm on the day of the morning shift than the group with poor tolerance. However, with regard to the sleepiness index, the corresponding difference between the groups with good or poor tolerance was not significant. The data did not confirm the hypothesis that predicts a quick adjustment of the circadian rhythm when the circadian amplitude is small before the change to night work. The contradictory results found in this and in other studies do not yet permit prediction of tolerance to night work.

Adult↗

PubMed1990

The relation of age to the adjustment of the circadian rhythms of oral temperature and sleepiness to shift work.

The relation of age to the adjustment of the circadian rhythms of oral temperature (T0) and sleepiness (S) in shift work was studied. 145 healthy female nurses underwent detailed laboratory and field measurements. Self-rated sleepiness, and oral temperature measured with a special extended-scale mercury thermometer, were recorded at 2 hr intervals during a morning (M) and 2 consecutive night (N) shifts. Sleeping times were registered during the same days. The results were analyzed separately in the age-groups of 22-29, 30-39 and 40-49-year-old subjects. From the morning shift to the second night shift day, the oral temperature and sleepiness acrophases shifted significantly (p less than 0.001) forward in all age groups. The amplitude decreased in the youngest and in the 30-39-year old age groups but not in the oldest age group. During the second night shift day, the acrophases and amplitudes of oral temperature rhythms were significantly different (P less than 0.05) between the groups, but there were no significant differences by age in the change of the circadian rhythms from morning to the second night shift days. The results thus fail to corroborate that physiological adjustment to night work would be influenced by age.

Adult↗

PubMed1989

Daytime napping and its effects on alertness and short-term memory performance in shiftworkers.

Daytime napping and its effects on 145 female shiftworkers were studied by comparing the individual characteristics, alertness, and short-term memory performance of subjects who took or did not take naps. Of the subjects 56% (n = 82) took a nap before a night shift and 21% (n = 30) after a morning shift. After a morning shift, napping was more frequent among evening types and subjects living alone (not married). Before a night shift, daytime napping was not connected to individual characteristics, but the total sleep time of nappers during the preceding night was shorter than that of non-nappers. At 10.00 and at 04.00-08.00, at the end of the night shift, nappers were significantly more alert than subjects who had not taken naps. The length and timing of the daytime nap did not correlate to either alertness or performance during the following night. In a questionnaire, nappers before a night shift had less sleep disturbances than non-nappers.

Adult↗

PubMed1989

Subjective health status of day and shift-working policemen.

To assess the subjective health status of day- and shift-working police officers, a questionnaire-based study was carried out. All the day-workers had previous shift experience. To control the age factor the total population of 2659 shift-working and 1303 day-working police officers was divided into four ten-year age classes. Factor analysis revealed that all the symptoms included in the questionnaire could be grouped into six factors. The prevalence rates of complaints showed that four of these factors (autonomous symptoms, musculo-skeletal symptoms, disturbance of appetite and indigestion, respiratory infections) were influenced by the main effects of age and shift work. Across all age classes the age-related changes in prevalence rates were strengthened by shift-work. In the other two factors (nervous symptoms, gastro-intestinal symptoms) an additional interaction effect could be observed. While the prevalence rates of the day-workers increased with age, those of the shift-workers decreased in the oldest age class. This drop of prevalence rates may be attributed to the influence of selection processes.

Adult↗

PubMed1988

Work at sea: a study of sleep, and of circadian rhythms in physiological and psychological functions, in watchkeepers on merchant vessels. III. Rhythms in physiological functions.

Oral and rectal temperature, urinary excretion of adrenaline and noradrenaline, and heart rate were measured in 28 watchkeepers working a "4-on/8-off" routine, and in 25 dayworkers, on board ships. Readings of oral temperature were taken over 4-hourly periods of up to two weeks; the rectal temperature, urine, and heart rate data were collected on selected days within these periods. Analysis of watchkeepers' temperatures and unconjugated catecholamine excretions showed slight signs of an interactive adaptation to time of day and hours of work, but it was clear that full phase adjustment of the circadian rhythms to shifted hours of work did not occur. The "split" pattern of sleep imposed by the watch system may be a major factor in preventing complete adaptation of physiological rhythms to shift work in the shipboard situation; this problem could be overcome by devising a system that allows sleep to be taken in a single uninterrupted block each day.

Body Temperature↗

PubMed1988

Work at sea: a study of sleep, and of circadian rhythms in physiological and psychological functions, in watchkeepers on merchant vessels. V. Effects of time zone crossings.

Daily diary records of sleep and activity, and 4-h measurements of body temperature, performance and subjective alertness were collected on board ship from 15 watchkeepers on the 4-on/8-off system, and from 28 dayworkers, on both westward and eastward transatlantic voyages. The data from a balanced sample of the subjects were analysed over selected 8-d periods of the voyages where four or five time zones were crossed. During these periods the average amount of daily sleep obtained by dayworkers on the eastward voyage was more than 1 h less than that on the westward voyage, and its quality was rated lower. Watchkeepers' main sleep was also shorter when travelling eastward, but this reduction was partially compensated for by a slightly longer secondary sleep. With the exception of subjective alertness on the eastward voyage, the basic phase of the circadian rhythms in the measured variables adjusted appropriately to the clock changes associated with the time zone crossings. The normal shape of the average daily curves was, however, altered differentially in the two directions of travel; as a result, morning levels of all variables were lower on the eastward voyage than on the westward, but evening levels were higher. These distortions of rhythm waveforms, which probably arose from a combination of endogenous and exogenous factors, add another dimension to the basic problem caused by the effects of circadian rhythms on operational efficiency in the shipboard situation. This problem can only be solved by the development of alternative watchkeeping systems which take full account of these rhythms.

Attention↗