Biomedical subjects
P Kirkegaard
Publications and source records attributed to P Kirkegaard.
Influence of epidermal growth factor on liver regeneration after partial hepatectomy in rats.
The role of epidermal growth factor on liver regeneration after partial hepatectomy in rats was investigated. After a 70% hepatectomy in rats, the concentration of epidermal growth factor in portal venous blood was unchanged compared with unoperated controls. However, small amounts of epidermal growth factor could be identified in portal venous blood after intestinal instillation of epidermal growth factor. Brunner's glands and the submandibular glands secrete epidermal growth factor. Extirpation of Brunner's glands decreased liver regeneration, whereas removal of the submandibular glands had no effect on liver regeneration. Epidermal growth factor antiserum reduced liver regeneration significantly. Oral or s.c. administration of epidermal growth factor had no effect on liver regeneration, whereas epidermal growth factor enhanced the effect of insulin and glucagon on liver regeneration. The results suggest that endogenous epidermal growth factor participates in stimulation of liver regeneration after partial hepatectomy in rats. Epidermal growth factor given together with insulin and glucagon had a synergistic effect on liver regeneration which suggests that liver regeneration in the rat is controlled by multiple regulatory peptides.
Complete prolapse of the rectum treated by modified Orr operation.
During a 25-year period 24 patients were treated for complete rectal prolapse with a modification of the operation described by Orr in 1947. After a median follow-up of five years two recurrences occurred (8 per cent). Of 11 patients who were incontinent for fluid feces or flatus preoperatively, five gained continence after the operations. An actuarial analysis of the data revealed a cure rate after five years of 91 per cent (95 per cent confidence limits: 76-100 per cent).
Time to request ABO-identity when transplanting for fulminant hepatic failure?
Explore the source record for details and available documents.
Ileal pouch-anal anastomosis after failure of straight ileoanal anastomosis. Case report.
The technique for creating an ileoanal anastomosis and an ileal reservoir with stapling technique is described. It was used in two patients in whom severe complications after colectomy and straight ileoanal anastomosis had necessitated ileostomy. The functional result was satisfactory.