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Biomedical subjects

P Kinnaert

Publications and source records attributed to P Kinnaert.

At least 145 records · Page 8Linked to original sources
PubMed1979

Comparison of three hemodialysis procedures with unipuncture.

Dialysis efficiency estimated by the decrease in urea, creatinine and phosphorus serum concentrations is higher with the double-lumen single-needle method, compared to the single-lumen needle unipuncture methods. This increased efficiency is related to a higher blood flow rate through the dialyser. Provided the superficial veins are not too small and/or tortuous, the double-lumen needle appears as a safe, simple and rewarding device and may be used in most patients on regular dialysis treatment.

Adult↗
PubMed1979

Kinetics of humoral responsiveness and antigenic distribution in operated rats.

Wistar R/A rats were injected intravenously with 10(9) sheep red blood cells (SRBC) prior to, during or after a standard laparotomy. Stimulation of anti-SRBC antibody synthesis was already observed when the antigen was given 4 h prior to surgery and was maximal if SRBC were administered at the time of operation. The enhancing effect on the immune response lasted for 2 days after surgery. From the third post-operative day on, the injection of SRBC induced a normal humoral response. No subsequent depression was detected. Inter-organ distribution studies of 51Cr-labelled SRBC injected at various times prior, during or after the surgical procedure, showed a maximum decrease of liver uptake during operation; the depression was still present 2 h later but on the first post-operative day, no significant difference from the controls could be demonstrated. When the labelled antigen was given before surgery, organ distribution was normal. Consequently, there is no time relationship between the stimulation of antibody production and the alteration of total phagocytosis induced by surgery. Therefore, the enhanced humoral response cannot be explained only by spillover of the antigen from the liver into lymphoid organs.

Abdomen↗
PubMed1978

Stimulation of antibody synthesis induced by surgical trauma in rats.

The effect of a standard laparatomy on antibody synthesis was studied in Wistar R/A rats recieving an intravenous injection of 10(9) sheep red blood cells (SRBC) during the surgical procedure. Anti-SRBC antibody titres were significantly higher in operated animals than in controls. When SRBC were given 2 hr after the surgical procedure, stimulation of antibody synthesis still persisted, but when the antigen was administered 24 hr after laparotomy, no significant difference could be detected between the operated animals and controls. Surgery also enhances the secondary humoral response.

Anesthesia, General↗
PubMed1977

Nine years' experience with internal arteriovenous fistulas for haemodialysis: a study of some factors influencing the results.

Data were collected concerning 314 internal arteriovenous fistulas created in 242 adult patients (92 women and 150 men). The immediate failure rate for the various techniques used ranged from 7-7 to 12-0 per cent, except for ulnar fistulas which had a rate of immediate thrombosis of 20-7 per cent. Survival rates were significantly lower for patients submitted to a combined therapy of dialysis and kidney transplantation when compared with patients treated with dialysis alone. The probability of survival of an arteriovenous fistula was lower in women than in men but the difference was significant only in patients undergoing transplantation. Survival rates at 2 years in dialysed patients were 87-6 per cent for distal radial-cephalic side-to-side fistulas, 100 per cent for radial-cephalic end-to-side fistulas located in the mid-forearm, 78-5 per cent for radial-cephalic end-to-side fistulas created near the wrist, 53-1 per cent for distal radial-cephalic end-to-end fistulas and 60-9 per cent for ulnar fistulas. Thrombosis was responsible for 87-2 per cent of 109 late failures. The incidence of infection was 1 case/11 patient years of haemodialysis.

Adult↗
PubMed1977

Kidney graft rejection crisis: time-evolution, prognostic significance and role in infection.

For 255 kidney grafts performed during the past twelve years, 622 rejection crises (RC) were analysed. Irreversible RC occurred more frequently in second than in first grafts during the first post-operative trimester. A clear relationship between long term graft tolerance and RC occurring during the first post-operative month was observed. Infection was related to RC in 61% of cases. Infections following corticosteroid therapy after short intervals were usually characterised by a poor prognosis. These clinical features have practical implications for immunosuppressive treatment.

Adult↗
PubMed1976

[Polycystic kidney treated by iterative hemodialysis and kidney transplantation. 25 cases].

Between January 1968 and December 1975, 25 patients (13 men and 12 women) were treated in the dialysis and transplantation unit of the Brugmann Hospital for terminal renal insufficiency secondary to polycystic disease. Nine patients (36%) underwent repeated surgery in order to ensure adequate successful vascular access for haemodialysis, whilst only 14.1% of patients suffering from renal insifficiency of another cause had to undergo operation on more than one occasion in order to be treated. In the majority of cases vasospasm was responsible for the obliteration of internal or external arterio-venous shunts. It was particularly common in women with a normal or low blood pressure. In this group, 3/4 of the patients needed several operations in order to make dialysis possible. Fourteen patients underwent bilateral nephrectomy. One death occurred in a patient who had received a renal transplant during the same operation. Fifteen kidney grafts were carried out and percentages of functional transplants at one and two years were 45.4 and 37.8% respectively. These poor results may be explained by the fact that 13 of our 15 patients were aged more than 40 years.

Age Factors↗
PubMed1976

Prognostic significance of hepatitis B antigenemia in kidney transplantation.

Serial hepatitis B antigen (HBAg) serum screenings were performed in 98 cadaver kidney transplant recipients: 51 were persistently found HBAg-negative while 47 became HBAg-positive, the majority of them acquiring HBAg postoperatively. In 28 patients, HB antigenemia persisted over 6 months postoperatively. 1- and 2-year graft survival rates were significantly greater in HBAg-positive than in HBAg-negative recipients. This finding suggests that HBAg tolerance is due to the ill-defined processes which determine kidney graft tolerance.

Adolescent↗