Biomedical subjects

P Kimmig

Publications and source records attributed to P Kimmig.

41 records · Page 3Linked to original sources

PubMed1979

[Diaplacental transmission of microfilaria of the species, Brugia pahangi, in the cat].

Eight kittens born of two Brugia pahangi infected cats have been studied for transplacental passed microfilariae. In the peripheral blood microfilariae could not be demonstrated at any time. However, in the lung of a young cat killed two days post partum ca. 30 microfilariae have been found (microfilaremia of the mother 90 mf/20 mm3). Histological studies suggested two possibilities of transplacental passage--by blood and by secretion of the uterus glands.

Animals↗

PubMed1979

[Sarcosporidiosis (sarcocystis suihominis) in man (author's transl)].

Eleven medical students and six members of the Institute of Medical Parasitology, University of Bonn participated in a meal with raw pork of an experimentally Sarcocystis suihominis infected pig. During the first two days the test persons suffered from the same symptoms as a previous group (see Piekarski et al., 1978). The severity of the symptoms was related ito certain degree to the quantity of the pork comsumed, but the individual reaction varied considerably; one test person with a higher amount of meat remained healthy. Apparently, only excessively high quantities of infected meat lead to severe symptoms. Lower dosages cause a protracted course of the disease. In general, the Sarcosporidia infection produces a transitory disease which quickly disapprears without remaining after-effects.

Alanine Transaminase↗

PubMed1978

[Clinical, parasitological and serological investigations in sarcosporidiosis (sarcocystis suihominis) of man (author's transl)].

Eight medical students ate for a test raw meat from a pig experimentally infected with sporocysts of Sarcocystis suihominis. The meat had been officially controlled before and was found free of Trichinella and qualified for consumption. 6 to 24 hours after the meal all persons suffered from acute clinical symptoms, above all diarrhoea and vomiting, coldness and sweating which decreased, however, within 12 to 24 hours. Clinical-chemical investigations made during this time suggested an acute infection combined with an exsiccosis; the specificity of the infection, however, could only be established by serological methods and by microscopical demonstration of sporocysts of the agent. The pathogenetic relations are discussed.

Adult↗

PubMedDate not supplied

[Current problems of echinococcosis (Echinococcus multilocularis)].

Alveolar echinococcosis is by far the most dangerous human parasitosis in Central Europe. For the one part this is due to the fact that the parasite is localised in the liver, and for the second part it is due to the infiltrative growth of the larval cestode tissue. The life cycle of echinococcus multilocularis takes place primarily between the fox as final host and mice as intermediate hosts. In this cycle, man is an accidental host and is infected orally via the intake of cestode eggs. The individual channels of infection and their frequency have so far only been subject to speculation. The infection rate of foxes is highest in the range of the Swabian mountain pastures (known as Schwäbische Alb) (up to 55 per cent), but recently values of more than 30% have been registered in the adjacent areas as well. No accurate data are available on the infection rate in humans; seroepidemiological data indicate a prevalence between 0.1 and 0.5 per thousand. IHA, IIFT and ELISA are the most frequently used methods in serodiagnostics of echinococcosis. The specific E. multilocularis antigen should be used instead of the commercially available E. granulosus antigen when examining patients for alveolar echinococcosis. In clinical diagnostics, sonography and especially CT are well tried. If the parasitic infestation is discovered early, radical surgery is the method of choice. Chemotherapy with mebendazole (e.g. Vermox) is still unsatisfactory despite improvements. Possibly an echinococcus therapy of foxes via baits containing praziquantel may be a possibility to minimize the transfer to the human organism.

Animals↗

PubMedDate not supplied

[Sensitivity and specificity of test results in HIV].

In HIV tests, the sensitivity is important, but even more so is the specificity, i.e., the reliability of positive tests results. A third parameter, the positive predictive value, is connected with these test characteristics; but even more it depends to a high degree on the prevalence of the infection. To solve these general problems, highly purified virus antigens as well as step testing are used in HIV diagnosis. Initially, screenings test (ELISA, IFA, various so-called quick tests) are used to filter out those suspected of being infected from the mass of non-infected persons. For this population with an increased HIV prevalence, confirmation tests are performed. With the indirect immunofluorescence assay, it is possible to distinguish antiviral from anticellular antibody reactions. With the so-called immunoblot, the immune response against individual virus proteins can be determined. The sensitivity of HIV tests is approximately 99-100%. As for the specificity, only 1 false positive result per 50,000-100,000 tests is expected. AIDS infections before seroconversion can be diagnosed only by detecting the virus or compounds of it. This is hardly possible with virus Antigen-ELISA and virus cultivation. On principle, nucleic acid hybridisation after DNA multiplication by polymerase chain reaction would be suitable. However, there are still some technical problems and questions of interpretation of results with this method. It is also very complicated and thus out of the question for routine examination.

AIDS Serodiagnosis↗